A5036330144- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Circadian rhythm and melatonin
- Cardiovascular Health and Disease Prevention
- Sodium Intake and Health
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular and exercise physiology
- Climate Change and Health Impacts
- Hemodynamic Monitoring and Therapy
- Nutritional Studies and Diet
- Mine drainage and remediation techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Maternal and fetal healthcare
- Sleep and related disorders
- Thermoregulation and physiological responses
- Diet and metabolism studies
- Cardiovascular Health and Risk Factors
- Hormonal Regulation and Hypertension
- Metal Extraction and Bioleaching
- Growth Hormone and Insulin-like Growth Factors
- Gestational Diabetes Research and Management
- Dietary Effects on Health
- Eicosanoids and Hypertension Pharmacology
Universidad de Las Américas
2024
Universidad del Rosario
2023
Pennsylvania State University
2019-2022
Universidad Estatal de Bolívar
2021
Universidade de Vigo
2011-2020
Instituto de Investigación Geológico y Energético
2015
University Hospital Complex Of Vigo
1998-2007
University of Minnesota Medical Center
2005
Fundación Ramón Domínguez
2004
Complejo Hospitalario Universitario de Santiago
2002-2004
Clinical studies have documented morning-evening, administration-time differences of several different classes hypertension medications in blood pressure (BP)-lowering efficacy, duration action, safety profile, and/or effects on the circadian BP pattern. In spite these published findings, most hypertensive subjects, including those under combination therapy, are instructed by their physicians and pharmacists to ingest all BP-lowering morning. The potential differential reduction...
The Hygia Chronotherapy Trial, conducted within the clinical primary care setting, was designed to test whether bedtime in comparison usual upon awakening hypertension therapy exerts better cardiovascular disease (CVD) risk reduction.In this multicentre, controlled, prospective endpoint trial, 19 084 hypertensive patients (10 614 men/8470 women, 60.5 ± 13.7 years of age) were assigned (1:1) ingest entire daily dose ≥1 medications at (n = 9552) or all them 9532). At inclusion and every...
Time of ingestion hypertension medications can affect circadian patterns BP, but whether this translates into an effect on clinical outcomes is unknown. Here, in open-label trial, we randomly assigned 661 patients with CKD either to take all prescribed upon awakening or at least one them bedtime. We measured 48-hour ambulatory BP baseline and 3 months after any adjustment treatment or, the least, annually. After a median follow-up 5.4 years, who took BP-lowering medication bedtime had...
Therapeutic strategies in resistant hypertension include adding another drug or changing drugs search for a better synergic combination. Most patients, however, receive all of their single morning dose. We have evaluated the impact on circadian pattern blood pressure modifying time treatment without increasing number prescribed drugs. studied 250 hypertensive patients who were receiving 3 antihypertensive Patients randomly assigned to 1 2 groups according modification strategy: but keeping...
OBJECTIVE We prospectively investigated in hypertensive patients with type 2 diabetes if bedtime treatment ≥1 hypertension medications exerts better blood pressure control and cardiovascular risk reduction than conventional therapy, which all are ingested the morning. RESEARCH DESIGN AND METHODS conducted a prospective, randomized, open-label, blinded end point trial on 448 diabetes, 255 men/193 women, mean ± SD age 62.5 10.8 years, randomized to ingest their prescribed upon awakening or of...
Correlation between systolic (SBP) and diastolic (DBP) blood pressure (BP) level target organ damage, cardiovascular disease (CVD) risk, long-term prognosis is much greater for ambulatory BP monitoring (ABPM) than daytime office measurements. The 2013 ABPM guidelines specified herein are based on patient outcomes studies constitute a substantial revision of current knowledge. asleep SBP mean sleep-time relative decline the most significant predictors CVD events, both individually as well...
Numerous studies have consistently shown an association between blunted sleep-time relative blood pressure (BP) decline (non-dipping) and increased cardiovascular disease (CVD) risk in hypertension. Normotensive persons with a non-dipper BP profile also target organ damage, namely, left ventricular mass wall thickness, reduced myocardial diastolic function, urinary albumin excretion, prevalence of diabetic retinopathy, impaired glucose tolerance. It remains point contention, however, whether...
Preeclampsia and gestational hypertension are major contributors to perinatal morbidity mortality. Several studies aimed test the effects of low-dose aspirin (ASA) in prevention preeclampsia concluded that beneficial such treatment outweigh adverse ones. Such benefits have not been fully corroborated by larger randomized trials usually carried out low-risk women, testing a dose 60 mg/d ASA presumably ingested morning, including women as late at 26–32 wks gestation. The authors conducted...
There is strong association between chronic kidney disease (CKD) and increased prevalence of hypertension, risk end-organ damage, cardiovascular (CVD). Non-dipping, as determined by ambulatory blood pressure (BP) monitoring (ABPM), frequent in CKD has also been consistently associated with CVD risk. The reported non-dipping highly variable, probably due to relatively small sample sizes, reliance only on a single, low-reproducibility, 24-h ABPM evaluation per participant, definition daytime...
therapeutic target for diminishing CVD risk is uncertain.We investigated whether reduction most associated with progressive decrease of either office or ambulatory awake asleep BP mean..........
There is strong association between diabetes and increased risk of end-organ damage, stroke, cardiovascular disease (CVD) morbidity mortality. Non-dipping (<10% decline in the asleep relative to awake blood pressure [BP] mean), as determined by ambulatory BP monitoring (ABPM), frequent consistently associated with CVD risk. The reported prevalence non-dipping highly variable, probably due differences study groups (normotensive subjects, untreated hypertensives, treated hypertensives),...
Abstract —With the aim to describe daily pattern of blood pressure during trimesters pregnancy in clinically healthy women as well pregnant who developed gestational hypertension or preeclampsia, we analyzed 1494 series systematically sampled by ambulatory monitoring for 48 hours every 4 weeks after first obstetric visit 124 with uncomplicated pregnancies, 55 hypertension, and 23 a final diagnosis preeclampsia. The circadian variation each group trimester gestation was established population...
This study investigated the administration time–dependent antihypertensive efficacy of valsartan, an angiotensin II receptor blocker. We studied 90 subjects (30 men and 60 women), 49.0±14.3 (mean±SD) years age with stage 1 to 2 essential hypertension; they were randomly assigned receive valsartan (160 mg/d) as a monotherapy either on awakening or at bedtime. Blood pressure was measured by ambulatory monitoring every 20 minutes during day 30 night for 48 consecutive hours before after 3...
Background The lack of nocturnal decline in blood pressure has been associated with an increase end-organ damage and cardiovascular events, although results remain controversial, partly because the inability to reproduce correctly, over time, classification patients into dippers non-dippers. Moreover, non-dipping status frequently related activity, differences quality sleep, or both. Objective To assess relationship between activity hypertension. Methods We studied 306 mild-to-moderately...
Previous results have indicated that valsartan administration at bedtime, as opposed to upon wakening, may improve the diurnal: nocturnal ratio of blood pressure without loss in 24-h coverage and efficacy.To investigate time-dependent antihypertensive efficacy non-dipper patients.We studied 148 patients with grade 1-2 essential hypertension, aged 53.0+/-12.6 years, who were randomly assigned receive (160 mg/day) a monotherapy either on awakening or bedtime. Blood was measured every 20 min...
Valsartan administration at bedtime as opposed to on wakening improves the sleep time-relative blood pressure decline toward a more dipper pattern without loss in 24-hour efficacy. Yet be determined is whether this time-dependent efficacy class-related feature, characteristic of all angiotensin receptor blockers or specific only valsartan. Terminal half-life major difference between blockers, being largest ( approximately 24 hours) for telmisartan. This trial investigated antihypertensive We...
Clinical studies have demonstrated a different effect on blood pressure of some angiotensin-converting enzyme inhibitors when administered in the morning versus evening. Their administration at bedtime resulted higher nighttime as compared with dosing. This study investigated time-dependent effects ramipril ambulatory pressure. We studied 115 untreated hypertensive patients, 46.7±11.2 years age, randomly assigned to receive (5 mg/d) monotherapy either awakening or bedtime. Blood was measured...
Patients with resistant hypertension present high prevalence of a non-dipper blood pressure pattern. Recent results indicate that non-dipping is related partly to the absence 24-hour therapeutic coverage in patients treated single morning doses. Accordingly, we investigated impact treatment time on pattern 700 basis clinic measurements who were studied by 48-hour ambulatory monitoring. Among them, 299 received all their medication awakening, and 401 taking ≥1 antihypertensive drug at...