A5039923030- Microplastics and Plastic Pollution
- Cancer Cells and Metastasis
- Recycling and Waste Management Techniques
- Effects and risks of endocrine disrupting chemicals
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Surgical Oncology
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Ferroptosis and cancer prognosis
- Colorectal and Anal Carcinomas
- Genital Health and Disease
- Immunotherapy and Immune Responses
- Head and Neck Cancer Studies
- Cerebrospinal fluid and hydrocephalus
- Gastric Cancer Management and Outcomes
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Pancreatitis Pathology and Treatment
- Trace Elements in Health
- Neurosurgical Procedures and Complications
- Drug Transport and Resistance Mechanisms
- Cancer Genomics and Diagnostics
Fatebenefratelli Hospital
1993-2024
Azienda Ospedaliera Fatebenefratelli e Oftalmico
2000-2022
Dana-Farber/Harvard Cancer Center
2011
Microplastics (MPs) are defined as plastic particles smaller than 5 mm. They have been found almost everywhere they searched for and recent discoveries also demonstrated their presence in human placenta, blood, meconium, breastmilk, but location toxicity to humans not reported date. The aim of this study was twofold: 1. To locate MPs within the intra/extracellular compartment placenta. 2. understand whether associated with possible structural changes cell organelles. Using variable pressure...
Background & Aims Adenocarcinomas of the pancreatobiliary system are currently classified by their primary anatomical location. In particular, pathological diagnosis intrahepatic cholangiocarcinoma is still considered as a exclusion metastatic adenocarcinoma. Periampullary cancers have been previously according to histological type differentiation (pancreatobiliary, intestinal), but overlapping morphological features hinder differential diagnosis. We performed an integrative...
In order to determine retrospectively the impact of some cytometric and immunohistochemical parameters on overall survival gastric cancer patients treated with surgery alone, paraffin-embedded tumor samples from 137 carcinoma undergoing curative resection 1987-1993 were analyzed by flow cytometry (FCM) immunohistochemistry (p53, c-erbB-2, PCNA expression). FCM-derived DNA ploidy fraction S-phase cells (SPF). Multiple regression analysis was applied prognostic significance conventional...
ERCC1 (excision repair cross-complementation group 1) expression predicts survival in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated chemoradiation. In order to evaluate the predictive role adjuvant setting, we investigated radically resected HNSCC who underwent surgery cisplatin chemoradiation.ERCC1 levels were determined by immunohistochemistry primary tumor tissues from 48 stage III-IV cancers. The median follow-up was 38.5 months (range: 5-121).High...
Breast cancer represents one of the leading causes death among women. Surgery can be effective, but once breast has metastasized, it becomes extremely difficult to treat. Conventional therapies are associated with substantial toxicity and poor efficacy due tumor heterogeneity, treatment resistance disease relapse. Moreover, immune checkpoint blockade appears offer limited benefit in cancer. The immunogenicity immunosuppressive microenvironment result scarce T-cell infiltration, a low...
Summary paragraph Microplastics are particles smaller than five millimetres obtained from the degradation of plastic objects abandoned in environment. can move environment to living organisms and, fact, they have been found fishes and mammals. Six human placentas, prospectively collected consenting women with uneventful pregnancies, were analyzed by Raman Microspectroscopy evaluate presence microparticles. Detected microparticles characterized terms morphology chemical composition. 12...
The placenta is a crucial interface between the fetus and maternal environment. It allows for nutrient absorption, thermal regulation, waste elimination, gas exchange through mother's blood supply. Furthermore, determines important adjustments epigenetic modifications that can change phenotypic expression of individual even long after birth. Polyethylene glycol (PEG) polyether compound derived from petroleum with many applications, medicine to industrial manufacturing. In this study, first...
The placenta is a crucial interface between the fetus and maternal environment. It allows for nutrient absorption, thermal regulation, waste elimination gas exchange through mother's blood supply. Furthermore, determines important adjustments epigenetic modifications that can change phenotypic expression of individual even long after birth.Polyethylene glycol (PEG) polyether compound derived from petroleum with many applications, medicine to industrial manufacturing. In this study, first...
475 patients with carcinoma at different sites (141 colon-rectum; 102 breast; 50 stomach; 48 kidney; 46 head and neck; 41 bladder; 47 other sites) submitted to surgery have been analyzed after histopathological staging grading, by flow cytometry (monoparametric DNA content analysis) immunohistochemistry (p53, c-erbB-2, PCNA expression). In breast cancer the presence of receptors for estrogen (ER) progesterone (PGR) has also determined. Flow cytometry-derived parameters were ploidy, fraction...
Background: Immunotherapy has revolutionized the approach to metastatic triple-negative breast cancers. Atezolizumab was approved for patients with cancers whose tumors express PD-L1, determined by SP 142 assay. To assess availability and practice of SP142 test we administered a survey all 15 pathology departments Lazio Region during six-month period. Methods: The comprised 12 questions regarding in departments, percentage positive tests, difficulties pathologists cases close cut-off value...
Abstract Background: Immunotherapy has revolutionized the approach to metastatic triple-negative breast cancers (mTNBC). Atezolizumab was approved for patients with mTNBC whose tumours express PD-L1, determined by SP 142 assay. To assess availability and practice of SP142 test we administered a survey all 15 Pathology Departments Lazio Region during 6-months period. Methods: The comprised 12 questions regarding in Departments, percentage positive tests, difficulties pathologists case close...