A5019785895- Acupuncture Treatment Research Studies
- Complementary and Alternative Medicine Studies
- Pain Management and Placebo Effect
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Musculoskeletal pain and rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Breast Implant and Reconstruction
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neuroscience of respiration and sleep
- Myofascial pain diagnosis and treatment
- Endometriosis Research and Treatment
- Pain Mechanisms and Treatments
- Pediatric Pain Management Techniques
- Eating Disorders and Behaviors
- Traditional Chinese Medicine Studies
- Neural dynamics and brain function
- Dermatology and Skin Diseases
- Memory and Neural Mechanisms
- Biomedical and Chemical Research
- Anesthesia and Pain Management
- Non-Invasive Vital Sign Monitoring
- Anesthesia and Neurotoxicity Research
Medizinische Hochschule Hannover
2014-2023
Technical University of Munich
2016-2017
Heidelberg University
2016-2017
Ludwig-Maximilians-Universität München
2016-2017
Harvard University
2015-2017
Massachusetts General Hospital
2013-2017
Athinoula A. Martinos Center for Biomedical Imaging
2013-2017
University Hospital Heidelberg
2017
Jena University Hospital
2011-2015
Brigham and Women's Hospital
2015
Objective Fibromyalgia (FM) is a chronic functional pain syndrome characterized by widespread pain, significant catastrophizing, sympathovagal dysfunction, and amplified temporal summation for evoked pain. While several studies have demonstrated altered resting brain connectivity in FM, not specifically probed the somatosensory system its role both somatic nonsomatic FM symptoms. Our objective was to evaluate primary cortex (S1) explore how sustained, deep tissue modulates this connectivity....
The brainstem is of tremendous importance for our daily survival, and yet the functional relationships between various nuclei, their projection targets, afferent regulatory areas remain poorly characterized. main reason this lies in sub-optimal performance standard neuroimaging methods area. In particular, fMRI signals are much harder to detect region compared cortical areas. Here we describe validate a new approach measure activation nuclei humans using sequences widely available tools...
Background Aδ and C fibers are the major pain-conducting nerve fibers, activate only partly same brain areas, differently involved in pain syndromes. Whether a stimulus excites predominantly or is commonly asked question basic research but quick test was lacking so far. Methodology/Principal Findings Of 77 verbal descriptors of sensations, "pricking", "dull" "pressing" distinguished best (95% cases correctly) between fiber mediated (punctate pressure produced by means von Frey hairs) (blunt...
Abstract The hippocampus (HPC) is functionally heterogeneous along the longitudinal anterior–posterior axis. In rodent models, gene expression maps define at least three discrete subregions, which also differ in function, and anatomical connectivity with rest of brain. humans, equivalent HPC subregions are less well defined, resulting a lack consensus neuroimaging approaches that limits translational study. This study determined whether data‐driven analysis, namely independent component...
To evaluate whether psychotherapy with somatosensory stimulation is effective for the treatment of pain and quality life in patients endometriosis-related pain.Patients a history endometriosis chronic pelvic were randomized to either (ie, different techniques acupuncture point stimulation) or wait-list control 3 months, after which all treated. The primary outcome was brain connectivity assessed by functional magnetic resonance imaging. Prespecified secondary outcomes included on 11-point...
ABSTRACT Objective Posttraumatic stress disorder (PTSD) and traumatic life events are often coupled to chronic pain, possibly linked by central sensitization. We wanted assess the prevalence of PTSD in pain patients a German university hospital outpatient clinic. Moreover, we evaluated extent indicators co-occurring traits sensitization comorbid patients. Methods retrospectively divided 914 into four groups depending on their trauma severity: no trauma, accidental interpersonal PTSD....
While autonomic outflow is an important co-factor of nausea physiology, central control this poorly understood. We evaluated sympathetic (skin conductance level) and cardiovagal (high-frequency heart rate variability) modulation, collected synchronously with functional MRI (fMRI) data during nauseogenic visual stimulation aimed to induce vection in susceptible individuals. Autonomic guided analysis neuroimaging data, using a stimulus-based (analysis windows set by protocol) percept-based...
Abstract Independent component analysis (ICA) is a widely used technique for investigating functional connectivity (fc) in magnetic resonance imaging data. Masked independent (mICA), that is, ICA restricted to defined region of interest, has been shown detect local fc networks particular brain regions, including the cerebellum, brainstem, posterior cingulate cortex, operculo‐insular hippocampus, and spinal cord. Here, we present mICA toolbox, an open‐source GUI toolbox based on FSL command...
Pain catastrophizing is prominent in chronic pain conditions such as fibromyalgia and has been proposed to contribute the development of widespreadness. However, brain mechanisms responsible for this association are unknown. We hypothesized that increased resting salience network (SLN) connectivity nodes default mode (DMN), representing previously reported pain-linked cross-network enmeshment, would be associated with widespreadness across body sites. applied functional magnetic resonance...
Central autonomic control nuclei in the brainstem have been difficult to evaluate non-invasively humans. We applied ultrahigh-field (7 T) functional magnetic resonance imaging (fMRI), and improved spatial resolution it affords (1.2 mm isotropic), putative that and/or sense pain-evoked cardiovagal modulation (high-frequency heart rate variability (HF-HRV) instantaneously estimated through a point-process approach). The time-variant HF-HRV signal was used guide general linear model analysis of...
Objective: Reduced perception of pain is a well‐established phenomenon in patients with anorexia nervosa (AN). We tested the hypothesis that altered processing within insula might account for reduced pain. Method: Heat thresholds were obtained nineteen AN and matched controls. Thereafter, thermode was used to deliver thermal painful stimuli right arm during functional magnetic resonance imaging (fMRI) measurements. Stimuli initiated 10 s from baseline resting temperature (32°C) three...
Acupuncture uses needles to stimulate certain parts of the body, inducing a specific sensation, termed DeQi, which many regard as essential for acupuncture's therapeutic effect. Here, we used newly developed tool, bodily sensation mapping, investigate spatial configuration acupuncture-induced sensations throughout body. Twenty-five participants randomly received acupuncture stimulation or tactile using von Frey filament at four different acuoints (HT7, PC6, ST36, and SP10) on left side...
: Pain drawings (PDs) are an important tool to evaluate, communicate, and objectify pain. In the past few years, there has been a shift toward tablet-based acquisition of PDs, several studies have conducted test usefulness, reliability, repeatability electronic PDs. However, our knowledge, no study investigated potential role PDs in clinical assessment treatment inpatients acute pain situations. The aim this was evaluate whether knowledge patients' PD improve doctors' understanding their...
Symptom drawings are widely used as a qualitative and quantitative method of assessing pain symptoms for both clinical research purposes. As electronic offer many advantages over classical pen-and-paper drawings, the last years have seen shift toward tablet-based acquisition symptom drawings. However, software that is in care requires special attention to usability aspects design provide easy access physically impaired or elderly patients.The aims this project were develop new app...
Somatic sensations induced by placebos are a frequent phenomenon whose etiology and clinical relevance remains unknown. In this study, we have evaluated the quantitative, qualitative, spatial, temporal characteristics of placebo-induced somatic in response to three different placebo interventions: (1) irritant solution, (2) laser stimulation, (3) imagined stimulation. The quality intensity evoked were assessed using McGill pain questionnaire visual analogue scales (VAS), while subjects’...
Cardiovascular regulation is integral to life. Animal studies have identified both neural and endocrine pathways, by which the central nervous system adjusts cardiac output peripheral vascular resistance changing physiological demands. The outflow of these pathways coordinated various regions based on afferent information from baroreceptors, chemoreceptors, nociceptors, circulating hormones, modulated physiologic behavioural state. In humans, however, knowledge cardiovascular below cortical...