A5069512390- Sepsis Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Immune Response and Inflammation
- Hip and Femur Fractures
- Respiratory Support and Mechanisms
- Inflammation biomarkers and pathways
- Acute Myocardial Infarction Research
- Cardiac Ischemia and Reperfusion
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- MicroRNA in disease regulation
- Thermal Regulation in Medicine
- Protease and Inhibitor Mechanisms
- Anesthesia and Neurotoxicity Research
- Cell Adhesion Molecules Research
- Medical Research and Treatments
- Menopause: Health Impacts and Treatments
- Toxin Mechanisms and Immunotoxins
- Boron Compounds in Chemistry
- Transgenic Plants and Applications
- Inflammatory Biomarkers in Disease Prognosis
Fudan University
2014-2025
Sun Yat-sen University
2011-2025
The First Affiliated Hospital, Sun Yat-sen University
2011-2025
Zhongshan Hospital
2012-2025
Weatherford College
2022
Creative Commons
2022
Shanghai Medical College of Fudan University
2011-2017
XinHua Hospital
2010
J Clin Hypertens (Greenwich) . 2012;14:256–260. ©2012 Wiley Periodicals, Inc. Aortic dissection (AD) is a life‐threatening condition that requires immediate diagnosis and surgical correction. Patients with acute AD usually present clinically an insignificant medical history, leading to high probability of misdiagnosis. The aim the study was investigate number misdiagnoses patients in order understand this problem avoid future misdiagnosis emergency department. Clinical data from 361 admitted...
Tissue factor (TF) and tissue pathway inhibitor (TFPI) play a central role in the endothelial permeability regulation dysfunction, which is associated with development of sepsis acute lung injury/acute respiratory distress syndrome (ALI/ARDS). The aim this study to assess diagnostic prognostic values TF TFPI patients sepsis-induced ARDS. A total 62 sepsis, 167 severe 32 healthy volunteers were enrolled prospective observational study. levels measured by enzyme-linked immunosorbent assay...
Abstract Introduction Deregulated or excessive host immune responses contribute to the pathogenesis of sepsis. Toll-like receptor (TLR) signaling pathways and their negative regulators play a pivotal role in modulation development The objective this study was investigate association variants TLR pathway genes regulator with susceptibility sepsis Chinese Han population. Methods Patients severe ( n = 378) healthy control subjects 390) were enrolled. Five genes, namely TLR2, TLR4, TLR9, MyD88...
Background Tumor necrosis factor (TNF) and TNF receptor superfamily (TNFR)-mediated immune response play an essential role in the pathogenesis of severe sepsis. Studies examining associations lymphotoxin-α (LTA) single nucleotide polymorphisms (SNPs) with sepsis have produced conflicting results. The objective this study was to investigate whether genetic variation TNF, LTA, TNFRSF1A TNFRSF1B associated susceptibility or death from Chinese Han population. Methodology/Principal Findings Ten...
Abnormal expression of microRNAs (miRNAs) has been associated with aortic dissection (AD). Next-generation sequencing was performed to identify the differentially expressed miRNAs in tissue samples between AD and nondiseased individuals. Selected miRNAs, which showed significant variation 2 groups, were then transfected into human vascular smooth muscle cells, assessed for effects on cell migration induced apoptosis. The changes gene pattern cells also investigated. Among 314 detected...
Abstract Objectives We aimed to evaluate sex-specific 0-h high-sensitivity cardiac troponin T (hs-cTnT) thresholds for risk stratification in patients with suspected non-ST-segment elevation myocardial infarction (NSTEMI). Methods This retrospective study investigated a derivation cohort of 6,691 (44.4 % female and aged 65 (57–72) years) validation 6,589 (48.4 63 (50–71) NSTEMI who visited the emergency department. Uniform were derived validated, their performances compared. Results In...
Abstract Background Sepsis is a life-threatening illness with challenging diagnosis. Rapid detection the key to successful treatment of sepsis. To investigate diagnostic value, plasma protein profiles inflammatory biomarkers, cytokines, and endothelial functional markers were compared between healthy controls, SIRS, septic patients. Methods The performed by Luminex Assay in cohort 50 SIRS patients, 82 patients 25 controls. Fourteen proteins analyzed same cohort: IL-1β, IL-6, IL-8, IL-10,...
Abstract Background Acute type A aortic dissection (AAAD) is a devastating disease. Human smooth muscle cells (HASMCs) exhibit decreased proliferation and increased apoptosis, integrin α5β1 FAK are important proangiogenic factors involved in regulating angiogenesis. The aim of this study was to investigate the role patients with AAAD potential underlying mechanisms. Methods Aortic tissue samples were obtained from 8 4 organ donors at Zhongshan Hospital Fudan University. level apoptosis...
This study aimed to analyze the characteristics of patients who fail high-flow nasal cannula(HFNC) therapy for acute hypoxemic respiratory failure(AHRF) and identify predictors treatment failure. single-center, retrospective, observational analyzed clinical data from 388 with AHRF. Patients were divided into two groups: HFNC success group (HFNC-S, n = 256) failure (HFNC-F, 132). The primary endpoint was need escalation support tracheal intubation in enrolled patients. demographic data,...
Recent studies showed that overwhelming inflammatory response mediated by the toll-like receptor (TLR)-related pathway was important in development of acute lung injury (ALI). The aim this study to determine whether common genetic variation four genes TLR signaling were associated with sepsis-induced ALI susceptibility and risk death Chinese Han population. Fourteen tag single nucleotide polymorphisms (tagSNPs) MyD88, IRAK1, IRAK4 TRAF6 genotyped samples (n = 272) sepsis alone patients 276),...
Abstract Background Toll like receptors (TLRs) signaling pathways, including the adaptor protein Mal encoded by TIRAP gene, play a central role in development of acute lung injury (ALI). Recently, variants have been described association with susceptibility to inflammatory diseases. The aim this study was investigate whether genetic are associated ALI. Methods A case-control collection from Han Chinese 298 healthy subjects, 278 sepsis-associated ALI and 288 sepsis alone patients were...
Acute aortic dissection (AAD) is a serious vascular disease. Currently the diagnosis relies on clinical and radiological means whereas serum biomarkers are lacking. The purpose of this study was to identify potential for AAD using isobaric tags relative absolute quantitation (iTRAQ) approach. A total 120 samples were collected from three groups: patients (n = 60), with acute myocardial infarction (AMI, n 30), healthy volunteers first 10 each group used iTRAQ analysis. Using approach, 174...
The purpose of this study was to evaluate the utility potential serum biomarkers for acute aortic dissection (AAD) that were identified by isobaric Tags Relative and Absolute Quantitation (iTRAQ) approaches. Serum samples from 20 AAD patients healthy volunteers analyzed using iTRAQ technology. Protein validation performed 120 with chest pain. A total 355 proteins approach; 164 reached strict quantitative standard, 125 increased or decreased more than 1.2-fold (64 61 up- downregulated,...
Acute aortic dissection (AAD) is a devastating cardiovascular disease with high rate of disability and mortality. This often rapidly progresses to fatal multiple organ hypoperfusion, the incidence has been increasing in recent years. However, molecular mechanisms have yet be clarified. study aimed at identifying differential abundance proteins (DAPs) arch tissues patients AAD by proteomics select possible involved pathogenesis.The fresh obtained from 5 1 healthy donor were analyzed...
The aim of the present study was to investigate association between serum lumican levels and acute aortic dissection (AAD) severity. A total 82 patients with chest or back pain 30 healthy volunteers were recruited. Among patients, there 70 cases AAD 12 intramural hematoma (IMH). severity determined using multi-slice computed tomography angiography (MSCTA). Serum collected from upon admission, detected an enzyme-linked immunosorbent assay. In addition, correlation analyses conducted by...
Cavity effusion is common in patients with infectious diseases. However, the incidence rate and characteristics of serous cavity effusions (SCE) septic are not clear to date. The objective this study was investigate SCE explore correlations between bloody illness severity/prognosis patients. From January 2010 2015, a total 214 severe sepsis shock were enrolled retrospective observational study. Thoracentesis or abdominal paracentesis performed 45 because massive pleural ascites. serum...
Effective therapies to reduce ischemia/reperfusion and hypoxia/reoxygenation injury are currently lacking. Furthermore, the effects of loperamide microRNA (miR)-21 on cardiomyocytes have remained be elucidated. Therefore, present study aimed investigate effect miR-21 during injury, explore underlying molecular mechanisms. H9c2 rat were pre-treated with prior hypoxia/reoxygenation. The viability cells was measured a cell counting kit 8 apoptosis detected an Annexin...
Several lines of in vivo evidence demonstrated that activation δ-opioid receptors (ORs) with agonists mimics the cardioprotective effect ischemic preconditioning. However, subtypes ORs involved and molecular cellular mechanisms are not entirely clear. To investigate significance contribution by δ to cardiomyocyte survival, we used an vitro model hypoxia/reoxygenation (H/R) primary cultures neonatal rat cardiomyocytes study role different apoptosis relevant downstream signaling pathway. The...
Abstract Introduction Activation of inflammation and coagulation was closely related mutually interdependent in sepsis. Tissue factor (TF) its endogenous inhibitor, tissue pathway inhibitor (TFPI) the main regulators initiation process. Altered plasma levels TF TFPI have been to worse outcome The objective this study investigate whether single nucleotide polymorphisms (SNPs) genes were associated with risk for patients severe Methods Seventeen SNPs genotyped samples sepsis ( n =577) =476),...
We sought to find a bedside prognosis prediction model based on clinical and image parameters determine the in-hospital outcomes of acute aortic dissection (AAD) in emergency department.Patients who presented with AAD from January 2010 December 2019 were retrospectively recruited our derivation cohort. Then we prospectively collected patients 2020 2021 as validation demographics, medical history, treatment options, outcomes. All enrolled underwent computed tomography angiography. The data...
Estrogen is known to stimulate endothelial nitric oxide production and attenuate dysfunction after ischemia reperfusion. However, estrogen therapy increases the risk of breast endometrial cancer. The present study was designed determine whether idoxifene, a selective receptor modulator without adverse effects on reproductive organs, may release protect function. In U-46619 precontracted superior mesenteric arterial (SMA) segments isolated from ovariectomized rats, idoxifene 17 beta-estradiol...