A5077656328- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Hemoglobinopathies and Related Disorders
- Optical Coherence Tomography Applications
- Corneal surgery and disorders
- Ocular Oncology and Treatments
- Drug-Induced Ocular Toxicity
- Vascular Tumors and Angiosarcomas
- Vascular Malformations Diagnosis and Treatment
- Neurological Complications and Syndromes
- Blood groups and transfusion
- Neurofibromatosis and Schwannoma Cases
- Retinopathy of Prematurity Studies
- Meningioma and schwannoma management
- Biomedical Research and Pathophysiology
- Melanoma and MAPK Pathways
- Lymphoma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Amyloidosis: Diagnosis, Treatment, Outcomes
Roche (United States)
2021
Roche (Switzerland)
2020
University of California, San Diego
2012-2017
Smith-Kettlewell Eye Research Institute
2012-2017
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2011-2016
University of Milan
2007-2016
Ospedale Maggiore
2008-2016
L V Prasad Eye Institute
2013-2015
La Jolla Alcohol Research
2015
Jacobs (United States)
2013-2014
PurposeTo evaluate the safety and efficacy of Port Delivery System with ranibizumab (PDS) for neovascular age-related macular degeneration (nAMD) treatment.DesignPhase 2, multicenter, randomized, active treatment–controlled clinical trial.ParticipantsPatients diagnosed nAMD within 9 months who had received 2 or more prior anti–vascular endothelial growth factor intravitreal injections were responsive to treatment.MethodsPatients randomized 3:3:3:2 receive PDS filled 10 mg/ml, 40 100 monthly...
The purpose of this study was to assess changes in the neural retina eyes with different stages diabetic retinopathy (DR) comparison age-matched healthy subjects.Retrospective analysis spectral-domain optical coherence tomography (SD-OCT) scans 76 naïve 62 subjects diabetes performed. Key exclusion criteria included presence macular edema, any other retinal disease, history treatment for DR, or incorrect segmentation layers on SD-OCT scans. Eyes from patients were divided into three groups,...
Purpose: To evaluate the repeatability and reproducibility of manual choroidal volume (CV) measurements by spectral domain- optical coherence tomography (SD-OCT) using enhanced depth imaging (EDI).
The Port Delivery System with ranibizumab (PDS) is an innovative intraocular drug delivery system designed for the continuous of into vitreous 6 months and beyond. PDS includes ocular implant, a customized formulation ranibizumab, four dedicated ancillary devices initial fill, surgical implantation, refill-exchange, explantation, if clinically indicated. Ranibizumab ideal candidate on account its unique physicochemical stability high solubility. Controlled release achieved via passive...
Background and Objective This study evaluated treatment patterns outcomes among patients with diabetic macular edema (DME) treated the bispecific antibody faricimab in routine clinical practice United States. Patients And Methods FARETINA-DME was a retrospective DME initiating from February 2022 to June 2023 identified States IRIS ® Registry. Results Four thousand five hundred fourteen (4,514) (6,204 eyes) previously anti-vascular endothelial growth factor (anti-VEGF) therapy 691...
Purpose: To compare the visualization of epiretinal membrane (ERM) using multicolor imaging (MCI) (Heidelberg Engineering, Carlsbad, CA) and conventional white light flood color fundus photography (FP) (Topcon). Methods: The paired images patients with ERM who underwent same-day MCI FP examinations were reviewed. Visibility was graded a scale (0: not visible, 1: barely 2: clearly visible) by masked readers, surface folds counted to quantify visibility for each method. Images from individual...
Abstract Background Serous chorioretinopathy has been associated with MEK inhibitors, including cobimetinib. We describe the clinical features of serous retinopathy observed cobimetinib in patients BRAF V600 -mutated melanoma treated Phase III coBRIM study. Methods In study, 493 were two randomly assigned treatment groups: and vemurafenib (n = 247) or 246). All underwent prospective ophthalmic examinations at screening, regular intervals during whenever ocular symptoms developed. Patients...
To describe macular lesions in patients with deferoxamine (DFO) retinopathy, and to follow their clinical course using multimodal imaging.The authors retrospectively reviewed charts imaging of 20 β-thalassemia diagnosed DFO retinopathy (40 eyes) after a minimum 10 years treatment. Imaging included fundus photography, near-infrared reflectance autofluorescence on confocal laser scanning ophthalmoscope, spectral domain optical coherence tomography.Mean age the was 45 years, mean duration...
Purpose.: We analyzed choroidal volume (CV) variations during childhood using enhanced depth imaging optical coherence tomography, and evaluated its association with age, axial length (AXL), sex, weight, height. Methods.: Imaging studies of the right eyes 52 healthy children were reviewed included in this study. Subjects underwent a complete ocular examination AXL measurement, as well raster macular scan Heidelberg Spectralis device. The choroid was segmented manually. Results.: 21 males 31...
To compare the real-time visualization of vitreoretino-choroidal structures using full-depth imaging (FDI) spectral domain optical coherence tomography (SD-OCT) and swept-source (SS)-OCT.Foveal scans both FDI SD-OCT (Heidelberg Spectralis) SS-OCT (Topcon Deep Range Imaging-OCT-1) were obtained in 40 normal eyes, eyes with macular pathologies, glaucoma. Full-depth images by manually enhancing vitreoretinal interface first then choroid while averaging each OCT B-scan 100 times....
The Port Delivery System with ranibizumab (PDS) consists of an implant that is a permanent, indwelling drug delivery device can be refilled through self-sealing septum and designed to continuously release customized formulation into the vitreous by passive diffusion porous titanium control element. Target rates via used in studies PDS patients neovascular age-related macular degeneration were selected based on clinical pharmacokinetic (PK) data from previously conducted intravitreal...
To compare the choroidal volume (CV) between emmetropic and highly myopic eyes, to assess if presence of fundus abnormalities, traction maculopathy, or neovascularization affects CV.We retrospectively reviewed imaging studies 98 eyes patients who underwent CV measurement on optical coherence tomography. We included 31 (Group 1), 36 without vitreoretinal pathologies 2), 21 with maculopathy 3), 10 history 3). Eyes chorioretinal atrophy were excluded. Regression analysis was performed evaluate...
Purpose To identify systemic risk factors for sickle cell maculopathy, and to analyze the microstructure of macula Sickle Cell Disease (SCD) patients by using automated segmentation individual retinal layers. Methods Thirty consecutive with SCD 30 matched controls underwent spectral-domain optical coherence tomography (SD-OCT) thickness measurement each layer; thicknesses were then compared normal controls. Demographic data, lab results collected patient; multivariate logistic regression...
Our purpose was to identify causative mutations and characterize the phenotype associated with genotype in 10 unrelated families autosomal recessive retinal degeneration. Ophthalmic evaluation DNA isolation were carried out pedigrees inherited degenerations (IRD). Exomes of probands from eight captured using Nimblegen V2/V3 or Agilent V5+UTR kits, sequencing performed on Illumina HiSeq. The DHDDS gene screened for remaining two Ashkenazi Jewish ancestry. Exome variants filtered detect...