A5079406199- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Gene expression and cancer classification
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Estrogen and related hormone effects
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Genomics and Chromatin Dynamics
- Computational Drug Discovery Methods
- Breast Cancer Treatment Studies
- Cancer-related Molecular Pathways
- Metal complexes synthesis and properties
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Genomic variations and chromosomal abnormalities
Madurai Kamaraj University
2014-2024
Cellular Research (United States)
2023
Madurai Medical College
2020
Cancer Genetics (United States)
2014-2017
Center for Genomic Science
2014
National Cancer Centre Singapore
2006-2010
National Cancer Centre Japan
2006-2009
Amsterdam University Medical Centers
2007
Amsterdam UMC Location Vrije Universiteit Amsterdam
2007
Shimadzu (Japan)
2006
Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation different oncogenic pathways. We sought identify major pathways gastric cancer (GC) with significant relationships patient survival. Using gene expression signatures, we devised an silico strategy map patterns pathway activation 301 primary cancers, the second highest cause global mortality. identified three (proliferation/stem cell, NF-kappaB, and Wnt/beta-catenin) deregulated majority (>70%)...
Successful tumor development and progression involves the complex interplay of both pro- anti-oncogenic signaling pathways. Genetic components balancing these opposing activities are likely to require tight regulation, because even subtle alterations in their expression may disrupt this balance with major consequences for various cancer-associated phenotypes. Here, we describe a cassette cancer-specific genes exhibiting precise transcriptional control solid tumors. Mining database gene...
We are a group of archaeologists, anthropologists, curators and geneticists representing diverse global communities 31 countries. All us met in virtual workshop dedicated to ethics ancient DNA research held November 2020. There was widespread agreement that globally applicable ethical guidelines needed, but recent recommendations grounded discussion about on human remains from North America not always generalizable worldwide. Here we propose the following guidelines, taking into...
Abstract Elevated expression of the PLA2G2A phospholipase in gastric cancer (GC) is associated with improved patient survival. To elucidate function and regulation GC, we analyzed a panel GC cell lines. was specifically expressed lines constitutive Wnt activity, implicating β-catenin–dependent signaling as major upstream regulator expression. The invasive ability PLA2G2A-expressing AGS cells enhanced by silencing, whereas cellular migration non–PLA2G2A-expressing N87 inhibited enforced...
Abstract Recurrent genomic amplifications and deletions are frequently observed in primary gastric cancers (GC). However, identifying specific oncogenes tumor suppressor genes within these regions can be challenging, as they often cover tens to hundreds of genes. Here, we combined high-resolution array-based comparative hybridization (aCGH) with gene expression profiling target focal high-level GC cell lines, identified RAB23 an amplified overexpressed Chr 6p11p12 Hs746T cells. High protein...
Vanadyl compounds of clinical significance are recommended as drugs against diseases such tuberculosis, diabetes, cancer, etc. In order to check the potential salphen ligands and oxovanadium(IV)-salphen complexes their binding with bovine serum albumin (BSA) is investigated. The constants measured at pH 7.4 using UV-vis absorption fluorescence techniques in range 10(3)-10(5) M(-1). quenching BSA appearance enhanced luminescence ligand/vanadium(IV) complex increased [quencher] show efficient...
Genomic aberrations are common in cancers and the long arm of chromosome 1 is known for its frequent amplifications breast cancer. However, key candidate genes 1q, their contribution cancer pathogenesis remain unexplored. We have analyzed gene expression profiles 1635 tumor samples using meta-analysis based approach identified clinically significant candidates from 1q. Seven including exonuclease (EXO1) consistently over expressed tumors, specifically high grade aggressive tumors with poor...
Doxorubicin (DOX) is one of the most effective and widely used chemotherapeutic agents. Its efficacy has been proven in various malignancies alone combined with other cytocidal However, clinical usefulness DOX restricted by risk developing congestive heart failure. Formation free radicals oxidative stress during treatment may result adverse side effects. Naringenin (NAR) potential bioflavonoids excellent antioxidant properties free-radical scavenging capability. This study was designed to...
Abstract Purpose: Previous reports using genome-wide gene expression data to classify breast tumors have typically used standard unsupervised or supervised techniques, both of which known limitations. We hypothesized that novel clinically relevant information could be revealed in these sets by an alternative analytic approach. Using a recently described algorithm, signature analysis (SA), we identified “modules,” comprising groups tightly coexpressed genes are conditionally linked particular...
Frequent amplification of 7q21‐22 genomic region is known in gastric cancer. Multiple genes including SHFM1 , MCM7 and COL1A2 were reported to be the potential cancer candidate this 20 Mb amplicon. This amplicon has two polycistrionic miRNA clusters present study, miR‐106b‐25 cluster located intron‐13 was identified express tumors. Among genes, are expressed intestinal type tumors, whereas diffuse Across miR‐25 co‐express with . On other hand, negative correlation observed between...
The identification of drug-responsive biomarkers in complex protein mixtures is an important goal quantitative proteomics. Here, we describe a novel approach for identifying such drug-induced alterations, which combines 2-nitrobenzenesulfenyl chloride (NBS) tryptophan labeling with two-dimensional gel electrophoresis (2DE)/mass spectrometry (MS). Lysates from drug-treated and control samples are labeled light or heavy NBS moiety separated on common 2DE gel, alterations identified by MS...
The identification of specific oncogenes and tumor suppressor genes in regions recurrent aneuploidy is a major challenge molecular cancer research. Using both oligonucleotide single-nucleotide polymorphism mRNA expression arrays, we integrated genomic transcriptional information to identify prioritize candidate increased decreased chromosomal copy number cohort primary breast cancers. Confirming the validity this approach, several previously-known (CN) alterations could be successfully...
Despite the advancements in cancer therapeutics, gastric ranks as second most common cancers with high global mortality rate. Integrative functional genomic investigation is a powerful approach to understand major dysregulations and identify potential targets toward development of targeted therapeutics for various cancers. Intestinal diffuse type tumors remain subtypes molecular determinants drivers these distinct unidentified. In this investigation, by exploring network gene coexpression...
The present study focused on the development of a novel biodegradable nanoparticle system based polyethyleneglycol-modified gelatin (PEG-GEL) and polylactic acid (PLA) biopolymers for improving photodynamic efficacy cyclohexane-1,2-diamino hypocrellin B (CHA2HB), potent therapeutic (PDT) agent. CHA2HB-loaded PEG-GEL/PLA nanoparticles showed near-spherical morphology with an average size 190 nm at PLA to PEG-GEL ratio 1:3. drug loading was sufficient enough produce potentially toxic reactive...
We have reported the synthesis of novel di & trisubstituted pyrroles and their biological activity.
Development of targeted therapeutics is still at its early stage for hepatocellular carcinoma (HCC) due to the incomplete understanding confounding regulations signaling pathway level. In this investigation, gene co-expression-based networking and integrative functional genomic modeling HCC mRNA profiles as processes were employed understand complex cascades involved in development toward avenues therapeutics. Multiple sets genes molecular biological during identified from analysis: (i) Loss...
The high spin Fe(<sc>iii</sc>) complex <bold>Fe(RhoCat)3</bold> is reported as a smart dual-modal <italic>T</italic><sub>1</sub> MRI-optical imaging probe to visualize the NO molecule and an acidic pH environment.