A5067734603- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Spatial Neglect and Hemispheric Dysfunction
- Alzheimer's disease research and treatments
- Multiple Sclerosis Research Studies
- Sleep and Wakefulness Research
- Advanced MRI Techniques and Applications
- Circadian rhythm and melatonin
- Neurobiology of Language and Bilingualism
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Spatial Cognition and Navigation
- Fetal and Pediatric Neurological Disorders
- EEG and Brain-Computer Interfaces
- Psychosomatic Disorders and Their Treatments
- Pain Management and Placebo Effect
- Sleep and related disorders
- Transcranial Magnetic Stimulation Studies
- Cerebrospinal fluid and hydrocephalus
- Restless Legs Syndrome Research
- Photoreceptor and optogenetics research
University of Parma
2013-2025
Istituto delle Scienze Neurologiche di Bologna
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
University of Bologna
2018-2024
Ospedale generale di zona San Camillo Treviso
2015-2021
Policlinico S.Orsola-Malpighi
2017-2020
IRCCS San Camillo Hospital
2010-2020
Fordham University
2020
University of Maryland, Baltimore County
2020
BioCruces Health research Institute
2020
Improvement in performance following cognitive training is known to be further enhanced when coupled with brain stimulation. Here we ask whether training-induced changes can maintained long term and, crucially, they extend other related but untrained skills. We trained overall 40 human participants on a simple and well established paradigm assessing the ability discriminate numerosity–or number of items set–which thought rely an “approximate sense” (ANS) associated parietal lobes....
To explore the neuropsychological profile and integrity of olfactory network in patients with COVID-19-related persistent dysfunction (OD).Patients OD underwent assessment Sniffin' Sticks evaluation. Additionally, both a control group brain MRI, including T1-weighted resting-state functional MRI (rs-fMRI) sequences on 3 T scanner. Morphometrical properties were evaluated olfaction-associated regions; rs-fMRI data analysed using graph theory at whole-brain level within standard parcellation...
There is emerging evidence suggesting that Alzheimer's disease a vascular disorder, caused by impaired cerebral perfusion, which may be promoted cardiovascular risk factors are strongly influenced lifestyle. In order to develop an understanding of the exact nature such hypothesis, biomechanical influence lifestyle pursued. An extended poroelastic model perfused parenchymal tissue coupled with separate workflows concerning subject-specific meshes, permeability tensor maps and blood flow...
This study investigated the ability of magnetic resonance spectroscopy (1H-MRS) posterior cingulate cortex (PCC) and brain volumetry to predict progression from mild cognitive impairment (MCI) Alzheimer's Disease (AD) on basis clinical classification at 2 years follow-up. Thirty-eight MCI patients, eighteen healthy older adults twenty-three AD patients were included in this study. All participants underwent a brain-MR protocol (1.5 T GE scanner) including high-resolution T1-weighted...
We report our single-center experience on the neurological manifestations of long COVID.This is a retrospective observational study. All consecutive patients referred to COVID outpatient clinic institute from January 21 2021 December 9 underwent general objective examination. Treatments and investigations (brain MRI, neuropsychological evaluation, or others) were prescribed an individual basis as per standard clinical practice. A follow-up visit was performed when appropriate. Descriptive...
The aim of this study was to determine which characteristics could better distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease (AD) at the mild cognitive impairment (MCI) stage, particular emphasis on visual space and object perception abilities.Fifty-three patients deficits that were eventually diagnosed probable DLB (MCI-DLB: n = 25) AD (MCI-AD: 28) a 3-year follow-up retrospectively studied. At first visit, underwent assessment including Qualitative Scoring Mini Mental...
Spatial abilities decline in normal aging and decrease faster earlier Alzheimer's disease (AD), but these deficits are under investigated. The main goals of this study were to assess visuospatial memory mild cognitive impairment (
Objectives: The aims of the current study are to 1) report frequency specific sleep disturbance symptoms in MCI and cognitive healthy older persons; 2) examine whether overall poor more common persons with compared controls and; 3) association between disturbances performance general domains separately persons. Methods: Data were collected at Fondazione Ospedale San Camillo Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Venice, Italy as part European VPH-DARE@IT project. We...
Hypnotic-focused analgesia (HFA) was produced in 20 highly hypnotizable subjects receiving nociceptive stimulations while undergoing functional magnetic resonance imaging (fMRI). The fMRI pattern brain cortex activation a painful stimulus recorded both during nonhypnosis and HFA. scanning protocol included the acquisition of T1-weighted structural scan, 4 scans, T2-weighted axial fluid attenuated inversion recovery (FLAIR) scan. Total time, including localization image acquisitions,...
White matter hyperintensities (WMHs) are acquired lesions that accumulate and disrupt neuron-to-neuron connectivity. We tested the associations between WMH load (1) regional grey volumes (2) functional connectivity of resting-state networks, in a sample 51 healthy adults. Specifically, we focused on positive (more damage, more volume/connectivity) to investigate potential route adaptive plasticity. WMHs were quantified with an automated procedure. Voxel-based morphometry was carried out...
Visual-constructional apraxia is a prominent feature of dementia with Lewy bodies (DLB) that might help to clinically distinguish it from Alzheimer's disease (AD). The main goal this study was assess performance on the copy intersecting-pentagon item Mini-Mental State Examination new Qualitative Scoring method for Pentagon Test (QSPT). In order determine which aspects drawings differentiate DLB AD, pentagon autopsy-verified (n = 16) and AD 15) patients were assessed using QSPT. qualitative...
Given that lexical-semantic decline precedes episodic memory deficits in the Alzheimer's disease (AD) timeline, it is expected performance on a task would be associated with mediotemporal volumes independently of association this region has early stage AD.Fifty patients mild cognitive impairment due to AD and 50 healthy adults completed tests skills (category fluency test), for semantically relevant material (prose non (Rey-Osterrieth Figure lexical-executive abilities (letter...
Abstract Objective Disorders of arousal (DoA) are characterized by an intermediate state between wakefulness and deep sleep, leading to incomplete awakenings from NREM sleep. Multimodal studies have shown subtle neurophysiologic alterations even during in DoA. The aim this study was explore the brain functional connectivity DoA metabolic profile anterior posterior cingulate cortex, given its pivotal role cognitive emotional processing. Methods Fifteen consecutive patients with (9 males, mean...
Abstract Introduction Narcolepsy type 1 (NT1) is a rare central sleep disorder characterized by selective loss of hypocretin/orexin (hcrt)-producing neurons in the postero-lateral hypothalamus that project to widespread areas brain and brainstem. The aim this study was explore group NT1 patients metabolic alterations pons their associations with disease features. Methods Twenty-one (16 M) twenty age-matched healthy controls (10 underwent H MRS on 1.5 T GE Medical Systems scanner. Metabolite...
Borderline personality disorder (BPD) is a type B primarily characterized by pattern of unstable interpersonal relationships, distorted self-concept, and intense emotional reactions, associated with extreme opposing mental behavioral states, which coexist lead to destructive behaviors such as self-harm, commonly recurring over time.. The Personality Inventory for the Diagnostic Statistical Manual Mental Disorders (DSM), Fifth Edition (PID-5) provides dimensional assessment maladaptive...
Mild Cognitive Impairment (MCI) patients experience problems in financial abilities that affect everyday functioning. To date, the neural correlates of decline this domain are unclear. This study aims at examining correlation between pattern brain atrophy MCI and performance on abilities. Forty-four thirty-seven healthy controls underwent structural magnetic resonance imaging, assessment abilitiesby means Numerical Activities Daily Living Financial battery (NADL-F). As compared to controls,...
Aims: To assess the correlation between cognitive functioning and 3 gait parameters (gait speed, cadence, stride length) in persons with mild impairment (MCI) cognitively healthy controls investigate linear correlations gray matter volumes. Materials Methods: Participants were recruited at IRCCS San Camillo Hospital, Venice, Italy (MCI=43; age-matched controls=43). underwent comprehensive neuropsychological assessment. Gait length, assessed BTS FREEMG 300 device. Three-dimensional (3D)...