A5040641188- Diabetes Treatment and Management
- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Pancreatic and Hepatic Oncology Research
- Chronic Kidney Disease and Diabetes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiovascular Syncope and Autonomic Disorders
- Peptidase Inhibition and Analysis
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Pregnancy and preeclampsia studies
- Cancer Immunotherapy and Biomarkers
- Hemodynamic Monitoring and Therapy
- Platelet Disorders and Treatments
- Pregnancy and Medication Impact
- Natural Antidiabetic Agents Studies
- Neurological Complications and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Amino Acid Enzymes and Metabolism
- Psidium guajava Extracts and Applications
- Lymphoma Diagnosis and Treatment
- Aortic aneurysm repair treatments
- Urinary Tract Infections Management
- Gestational Diabetes Research and Management
- Halal products and consumer behavior
The University of Sydney
2012-2025
Nepean Hospital
2015-2025
State Library of New South Wales
2022
Westmead Hospital
2022
Vels University
2021
Sydney Local Health District
2020
Regional Research Institute of Unani Medicine
2019
Pediatric Nephrology of Alabama
2016
Royal North Shore Hospital
2013-2015
Vijayanagara Institute of Medical Sciences
2014
Sodium/glucose cotransporter 2 (SGLT2) inhibitors are oral hypoglycemic agents used to treat patients with diabetes mellitus. SGLT2 block reabsorption of filtered glucose by inhibiting SGLT2, the primary transporter in proximal tubular cell (PTC), leading glycosuria and lowering serum glucose. We examined renoprotective effects inhibitor empagliflozin determine whether blocking entry into kidney PTCs reduced inflammatory fibrotic responses high an vitro model human PTCs. HK2 cells (human PTC...
Inflammatory responses are central to the pathogenesis of diabetic nephropathy. Toll-like receptors (TLRs) ligand-activated membrane-bound which induce inflammatory predominantly through activation NF-κB. TLR2 and 4 present in proximal tubular cells activated by endogenous ligands upregulated nephropathy, including high-mobility group box-1 (HMGB1) fibronectin. Human tubules were exposed 5 mM (control), 11.2 (approximating clinical diagnostic threshold for diabetes mellitus), 30 (high)...
Abstract Aim In addition to lowering blood glucose in patients with type 2 diabetes mellitus, dipeptidyl peptidase 4 (DPP4) inhibitors have been shown be antifibrotic and anti‐inflammatory. We previously that DPP4 inhibition human kidney proximal tubular cells exposed high reduced fibrotic inflammatory markers. Hence, we wanted demonstrate renoprotection an vivo model. Methods used a 1 diabetic animal model explore the renoprotective potential of saxagliptin independent lowering. induced...
Background and Objective Sodium glucose cotransporter 2 (SGLT2) is the main luminal transporter in kidney. SGLT2 inhibition results glycosuria improved glycaemic control. Drugs inhibiting this have recently been approved for clinical use suggested to potential renoprotective benefits by limiting glycotoxicity proximal tubule. We aimed determine of empagliflozin, an inhibitor, independent its lowering effect. Research Design Methods induced diabetes using a low dose streptozotocin protocol...
Background: Sarcopenia is associated with significant morbidity and mortality in patients chronic kidney disease. The prevalence of sarcopenia the dialysis population varies from 4% to 63%. However, risk factors Australian remain uncertain. Aim: To study on maintenance by using European Working Group Older People (EWGSOP) diagnostic criteria identify factors. Methods: We evaluated adult haemodialysis peritoneal this single-centre cross-sectional Australia. Patient’s clinical (age, gender,...
ABSTRACT Aim Fibrillary glomerulonephritis (FGN) is a rare deposition disease with unclear aetiology. There are limited case series of FGN described in the literature. Here, we describe clinicopathological characteristics and outcomes 26 patients diagnosed at an Australian tertiary centre for renal diseases over decade. Method(s) The present study includes biopsy‐proven between January 2011 December 2021. Results average age presentation was 60 years, female predominance. mean creatinine 205...
Background In addition to lowering blood glucose in patients with type 2 diabetes mellitus, dipeptidyl peptidase 4 (DPP4) inhibitors have been shown be antifibrotic. We previously that cation independent mannose-6-phosphate receptor (CIM6PR) facilitates the conversion of latent active transforming growth factor β1 (GFß1) renal proximal tubular cells (PTCs) and linagliptin (a DPP4 inhibitor) reduced this downstream reduction fibronectin transcription. Objective wanted demonstrate reduces high...
The newer antidiabetic medications have revolutionized management of diabetes.These include the sodium-glucose cotransporter 2 (SGLT2) inhibitors and long-acting glucagon-like peptide 1 (GLP-1) receptor agonists.These two classes drugs provide additional cardiovascular renal benefits beyond glycemic control, making them attractive choices in this new era diabetes therapy.The these weight loss improved blood pressure control.They a limited number adverse effects, including urinary tract...
Acute kidney injury in women during pregnancy and the puerperium is often ascribed to hypertensive complications of pregnancy, especially pre-eclampsia. However, rarer causes, including atypical hemolytic uremic syndrome (aHUS) can be triggered by pregnancy. We present a case woman with post-partum acute due aHUS, which was successfully treated C5a inhibitor eculizumab. also summary evaluation management thrombotic microangiopathy
Introduction: Inhaled fine and ultrafine particulate matter may affect organs other than the lung, including kidney. Recent studies have consistently shown possibility of air pollution in highly polluted countries to be nephrotoxic. However, like Australia, where quality generally adheres or remains below WHO standards, subtle yet consequential impacts chronic exposure seemingly safe levels traffic PM2.5, are a subject increasing significance. how such exposures peri-pregnancy period kidney...
Nephrotic syndrome presenting in pregnancy is rare and poses a diagnostic therapeutic challenge. Timing of renal biopsy important given the increased risk bleeding miscarriage, choice immunosuppression limited due to teratogenicity profiles standard drugs. We report discuss case minimal change disease diagnosed by during early treated with corticosteroids throughout pregnancy. Prompt diagnosis treatment glomerular are vital prevent poor maternal fetal outcomes.
Acute myocardial infarction is the leading cause of death.Streptokinase most commonly used thrombolytic agent.This study was conducted to compare in-hospital outcome patients with acute receiving streptokinase those not it.About 340 having MI were included in study.Two groups formed.Group 1 (SK Group) and Group 2(Non SK) streptokinase.For patient condition assessment In-hospital mortality primary end while mechanical electrical complications secondary points.Among patients, 255(75%) males...