A5047834695- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Cardiac Valve Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
- Dental Implant Techniques and Outcomes
- Tribology and Lubrication Engineering
- 3D Printing in Biomedical Research
- Polymer Nanocomposite Synthesis and Irradiation
- Electrophoretic Deposition in Materials Science
- Chemical Synthesis and Characterization
- Quantum Dots Synthesis And Properties
- Nonlinear Optical Materials Studies
- Advanced Photocatalysis Techniques
- X-ray Diffraction in Crystallography
- Pluripotent Stem Cells Research
- Orthopaedic implants and arthroplasty
- Dental materials and restorations
- Cardiac Ischemia and Reperfusion
University of Oxford
2015-2021
COMSATS University Islamabad
2011-2021
Bilkent University
2020
Abstract Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) enable human cardiac cells to be studied in vitro, although they use glucose as their primary metabolic substrate and do not recapitulate the properties of adult cardiomyocytes. Here, we have explored interplay between maturation by stimulation fatty acid oxidation culture 3D. We investigated metabolism hiPSC-CMs grown a monolayer 3D, porous collagen-derived scaffolds engineered heart tissue (EHT), measuring...
Abstract Tissue engineers have achieved limited success so far in designing an ideal scaffold for aortic valve; scaffolds lack mechanical compatibility, appropriate degradation rate, and microstructural similarity. This paper, therefore, has demonstrated a carbodiimide‐based sequential crosslinking technique to prepare valve extracellular matrix mimicking (ECM) hybrid from collagen type I hyaluronic acid (HA), the building blocks of heart ECM, with tailorable densities. Swelling studies...
In addition to biocompatibility, an ideal scaffold for the regeneration of valvular tissue should also replicate natural heart valve extracellular matrix (ECM) in terms biomechanical properties and structural stability. our previous paper, we demonstrated development collagen type I hyaluronic acid (HA)-based scaffolds with interlaced microstructure. Such hybrid were found be compatible cardiosphere-derived cells (CDCs) potentially regenerate diseased aortic valve. This paper focused on...
Currently, custom made heart implants suffer from critical imperfections in terms of mechanical incompatibility and uncontrolled degradation rate, which leads to premature vivo failure. Interpenetrating polymer networks (IPNs) are a success story drug delivery regenerative medicine where they offer fascinating morphologies tailored properties like controlled rate. This review will critically discuss the current state art with respect two most important biopolymers found valve, i.e. collagen...
Irrespective of cell type, stem therapy to prevent heart failure following myocardial infarction is beset by low donor retention. Cell loss may be prevented immobilisation within a supporting scaffold for application across the infarct, but cells must remain viable while vasculature develops into scaffold. Previously we have shown that cardiosphere derived (CDCs) can cultured on porous collagen scaffolds (Chen <i>et al</i>, J. Tissue. Sci. Eng. 2012). Here investigate whether CDC-seeded...