A5022295369- Seaweed-derived Bioactive Compounds
- Echinoderm biology and ecology
- Skin Protection and Aging
- Protein Hydrolysis and Bioactive Peptides
- Aquaculture Nutrition and Growth
- Marine Sponges and Natural Products
- Macrophage Migration Inhibitory Factor
- Food Quality and Safety Studies
- Natural product bioactivities and synthesis
- Meat and Animal Product Quality
- Insect Utilization and Effects
- Chromatography in Natural Products
- Medical and Biological Ozone Research
- Algal biology and biofuel production
- Antioxidant Activity and Oxidative Stress
- Phytochemical and Pharmacological Studies
- Polysaccharides and Plant Cell Walls
- Marine and coastal plant biology
- Food Industry and Aquatic Biology
- melanin and skin pigmentation
- Sperm and Testicular Function
- Neurological Disorders and Treatments
- Biochemical Analysis and Sensing Techniques
- Phytochemistry and Bioactive Compounds
- Vitamin C and Antioxidants Research
National Institute of Fisheries Science
2020-2024
Jeju National University
2013-2022
Government of the Republic of Korea
2015-2016
University of Mississippi
2014
Hankyong National University
2006-2008
Center for Genomic Science
2006
Microalgae are proposed to have powerful applications for human health in the pharmaceutical and food industries. Tetraselmis species (sp.), which green microalgae, were identified as a source of broad-spectrum health-promoting biological activities. However, bioactivity these has not been elucidated. We aimed confirm antioxidant, antiviral, anti-inflammatory effects sp. extract (TEE). TEE showed 2,2-diphenyl-1-picryl-hydrazyl-hydrate radical hydrogen peroxide scavenging activities reduced...
Brown seaweed is a rich source of fucoidan, which exhibits variety biological activities. The present study discloses the protective effect low molecular weight fucoidan (FSSQ) isolated from an edible brown alga, Sargassum siliquastrum, on lipopolysaccharide (LPS)-stimulated inflammatory responses in RAW 264.7 macrophages. findings revealed that FSSQ increases cell viability while decreasing intracellular reactive oxygen species production LPS-stimulated macrophages dose-dependently. reduced...
Fine dust (FD) particles have become a major contributor to air pollution causing detrimental effects on the respiratory system and skin. Although some studies investigated of FD system, their possible skin remain under-explored. We mediated inflammatory responses in keratinocytes, present outer layers tissues transfer potential macrophages. further evaluated anti-inflammatory polyphenolic derivative, diphlorethohydroxycarmalol (DPHC) isolated from Ishige okamurae against FD-induced...
Previous studies suggested that fucoidan with a molecular weight of 102.67 kDa, isolated from Hizikia fusiforme, possesses strong antioxidant activity. To explore the cosmeceutical potential fucoidan, its anti-photoaging and anti-melanogenesis effects were evaluated in present study. The effect was investigated ultraviolet (UV) B-irradiated human keratinocytes (HaCaT cells), where effectively reduced intracellular reactive oxygen species level improved viability UVB-irradiated cells without...
In this study, the anti-inflammatory activity of sulfated polysaccharides isolated from green seaweed Codium fragile (CFCE-PS) was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and zebrafish. The results demonstrated that CFCE-PS significantly increased viability LPS-induced cells a concentration-dependent manner. remarkably concentration-dependently reduced levels inflammatory molecules including prostaglandin E2, nitric oxide (NO), interleukin-1 beta, tumor...
We observed that exposure to phlorotannins, which include 6,6-bieckol, phloroeckol, dieckol and phlorofucofuroeckol isolated from an edible brown alga,<italic>Ecklonia cava</italic>, significantly inhibited high glucose–induced ROS cell death.
The effect of the administering DK (dieckol) isolated from<italic>Ecklonia cava</italic>on blood glucose level in hyperglycemia zebrafish. Thus, zebrafish could be efficiently used to evaluate a wide range anti-diabetic activities.
Fucoidan is a fucose-enriched polysaccharide, obtained from brown algae, with demonstrated antioxidant properties. However, traditional extraction methods using water or chemical-based have reduced yield and produced hazardous by-products. In this study, we isolated fucoidan at high enzyme-assisted extraction; the Celluclast enzyme assisted extract of
A comprehensive antioxidant evaluation was performed on enzymatic hydrolysates of Stichopusjaponicus (S. japonicus) using Vero cells and zebrafish models for in vitro vivo studies, respectively. S. japonicus hydrolyzed with food-grade enzymes (alcalase, α-chymotrypsin, flavourzyme, kojizyme, neutrase, papain, pepsin, protamex, trypsin), the free radical scavenging activities were screened via electron spin resonance (ESR) spectroscopy. According to results, contained high protein relatively...
Backgrounds: Melanogenesis, regulated by genetic, hormonal, and environmental factors, occurs in melanocytes the basal layer of epidermis. Dysregulation this process can lead to various skin disorders, such as hyperpigmentation hypopigmentation. Therefore, present study investigated effect ultrasonic-assisted ethanol extract (SHUE) from Sargassum horneri (S. horneri), brown seaweed against melanogenesis α-melanocyte-stimulating hormone (MSH)-stimulated B16F10 murine melanocytes. Methods:...
Lipid peroxidation means the oxidative degradation of lipids.The process from cell membrane lipids in an organism is generated by free radicals, and result damage.Phlorotannins, well-known marine brown algal polyphenols, have been utilized functional food supplements as well medicine to serve a variety purposes.In this study, we assessed potential anti-lipid activity phlorofucofuroeckol-A (PFF-A), one phlorotannins, isolated Ecklonia cava centrifugal partition chromatography 2,2-azobis...
The use of ionizing radiation and radioactive elements is becoming increasingly popular with the rapid developments in nuclear technology, radiotherapy, radio diagnostic methods. However, can directly or indirectly cause life-threatening complications such as cancer, burns, impaired immunity. Environmental contamination depletion ozone layer also contribute to increased levels exposure. Radioprotective natural products have particularly received attention for their potential usefulness...
Diphlorethohydroxycarmalol (DPHC) isolated from
In this study, we investigated the anti-allergic effects of 3,4-dihydroxybenzaldehyde (DHB) isolated from marine red alga, Polysiphonia morrowii, in mouse bone-marrow-derived cultured mast cells (BMCMCs) and passive cutaneous anaphylaxis (PCA) anti-dinitrophenyl (DNP) immunoglobulin E (IgE)-sensitized mice. DHB inhibited IgE/bovine serum albumin (BSA)-induced BMCMCs degranulation by reducing release β-hexosaminidase without inducing cytotoxicity. Further, dose-dependently decreased IgE...
Our previous studies have evaluated the bioactivities of a fucoidan isolated from Sargassum fusiforme (SF-F). To further investigate health benefit SF-F, in present study, protective effect SF-F against ethanol (EtOH)-induced oxidative damage has been vitro and vivo models. effectively improved viability EtOH-treated Chang liver cells by suppressing apoptosis. In addition, test results indicate that significantly dose-dependently increased survival rate zebrafish treated with EtOH. Further...