A5006262279- Nerve injury and regeneration
- Signaling Pathways in Disease
- Neuroblastoma Research and Treatments
- Neuropeptides and Animal Physiology
Yantaishan Hospital
2019-2021
Regeneration of injured peripheral nerves is an extremely complex process. Nogo-A (neurite outgrowth inhibitor-A) inhibits axonal regeneration by interacting with Nogo receptor in the myelin sheath central nervous system (CNS). The aim this study was to investigate effects and its on repair sciatic nerve injury rats. Sprague-Dawley rats (n=96) were randomly divided into 4 groups: control group (control), transection (model), immediate (immediate repair), delayed (delayed repair). euthanized...
Aim: To screen the differential genes in NogoA/NTR-related pathways that associate with sciatic nerve injury. Results: There was no difference expression of NogoA, NTR and Ntrk2. Differential existed 11 include Pathways closely related to injury are MAPK, endophagocytosis, apoptosis, neurotrophin signaling inflammatory mediators. NTRK1, FASLG, LDLR ADRB1 HTR2A model rats were downregulated compared control rats, IL1R1, CSF1R, BCL2L1 HRH1 upregulated rats. Conclusion: endophagocytic,...