A5100719251- Carbon Nanotubes in Composites
- Diamond and Carbon-based Materials Research
- Graphene research and applications
- Metabolomics and Mass Spectrometry Studies
- Electrochemical sensors and biosensors
- Conducting polymers and applications
- Neuroscience and Neural Engineering
- 3D Printing in Biomedical Research
- Analytical Chemistry and Sensors
- Supercapacitor Materials and Fabrication
- Fiber-reinforced polymer composites
- Microbial Metabolic Engineering and Bioproduction
- Cancer Cells and Metastasis
- Biofuel production and bioconversion
- Advanced Sensor and Energy Harvesting Materials
- Graphene and Nanomaterials Applications
- Cellular Mechanics and Interactions
- Insect symbiosis and bacterial influences
- Boron and Carbon Nanomaterials Research
- Carbon and Quantum Dots Applications
- Nanomaterials for catalytic reactions
- Gas Sensing Nanomaterials and Sensors
- Tryptophan and brain disorders
- Fullerene Chemistry and Applications
- Enzyme Production and Characterization
Indian Institute of Technology Mandi
2019-2025
Tel Aviv University
2021-2024
Integral University
2024
Shoolini University
2022-2023
Institute of Life Sciences
2022-2023
Chandigarh University
2023
Biotech Park
2021-2022
Michigan State University
2022
Indian Institute of Science Education and Research Pune
2021-2022
Karlsruhe Institute of Technology
2016-2020
The pathogenic mechanisms of Alzheimer's disease (AD) remain largely unknown and clinical trials have not demonstrated significant benefit. Biochemical characterization AD its prodromal phase may provide new diagnostic therapeutic insights. We used targeted metabolomics platform to profile cerebrospinal fluid (CSF) from (n=40), mild cognitive impairment (MCI, n=36) control (n=38) subjects; univariate multivariate analyses define between-group differences; partial least square-discriminant...
Nanosized gas sensor elements are potentially faster, require lower power, come with a limit of detection, operate at temperatures, obviate the need for expensive catalysts, more heat shock resistant and might even cost than their macro-counterparts. In last two decades, there have been important developments in key areas that make this promise reality. First is development variety very good performing nanostructured metal oxide semiconductors (MOSs), most commonly used materials sensing;...
The purpose of this study was to determine whether the baseline metabolic profile (that is, metabotype) a patient with major depressive disorder (MDD) would define how an individual will respond treatment. Outpatients MDD were randomly assigned sertraline (up 150 mg per day) (N=43) or placebo (N=46) in double-blind 4-week trial. Baseline serum samples profiled using liquid chromatography electrochemical array; output digitized create 'digital map' entire measurable response for particular...
Abstract Thermochemical decomposition of organic materials under heat-treatment in the absence oxygen, known as pyrolysis process, is often employed to convert micro and nano patterned polymers into carbon structures, which are subsequently used device components. Pyrolysis performed at ≥900 °C, entails substrate with a high thermal stability that excludes flexible, polymeric substrates. We use optimized laser radiation pattern graphitic structures onto commercially available polyimide...
Glassy carbon is a graphene-rich form of elemental obtained from pyrolysis polymers, which composed three-dimensionally arranged, curved graphene fragments alongside fractions disordered and voids. Pyrolysis encompasses gradual heating polymers at ≥ 900 °C under inert atmosphere, followed by cooling to room temperature. Here we report on an experimental method perform in situ high-resolution transmission electron microscopy (HR-TEM) for the direct visualization microstructural evolution...
Therapeutic response to selective serotonin (5-HT) reuptake inhibitors in Major Depressive Disorder (MDD) varies considerably among patients, and the onset of antidepressant therapeutic action is delayed until after 2 4 weeks treatment. The objective this study was analyze changes within methoxyindole kynurenine (KYN) branches tryptophan pathway determine whether differential regulation these may contribute mechanism variation Metabolomics approach used characterize early biochemical...
Abstract Endothelial cells express neuropilin 1 (NRP1), endoglin (ENG) and vascular endothelial growth factor receptor 2 (VEGFR2), which regulate VEGF-A-mediated development angiogenesis. However, the link between complex formation among these receptors with VEGF-A-induced signaling biology is yet unclear. Here, we quantify surface interactions by IgG-mediated immobilization of one receptor, fluorescence recovery after photobleaching (FRAP) measurements mobility another coexpressed receptor....
Single suspended carbon nanowires (CNWs) integrated on carbon-MEMS (CMEMS) structures are fabricated by electrospinning of SU-8 photoresist followed pyrolysis. These monolithic CNW-CMEMS enable fabrication very high aspect ratio CNWs predefined length. The thus display core–shell having a graphitic shell with glassy core. electrical conductivity these is increased about 100% compared to as result enhanced graphitization. We suggest some tunable and pyrolysis parameters that may improve...
In this contribution we report on results from an optimization study of SU-8 photoresist derived carbon electrodes. tends to be glassy in nature, however, based the exact pyrolysis strategy and other fabrication parameters employed one can obtain a range electrical, electrochemical thermal properties related variation graphitic content thus obtained carbon. Hence, order electrodes that emulate or improve upon performance commercially available (GC) electrodes, right choice conditions, such...
Abstract Background A critical and as-yet unmet need in Alzheimer disease (AD) research is the development of novel markers that can identify individuals at risk for cognitive decline due to AD. This would aid intervention trials designed slow progression AD by increasing diagnostic certainty, provide new pathophysiologic clues potential drug targets. Results We used two metabolomics platforms (gas chromatography-time flight mass spectrometry [GC-TOF] liquid chromatography LC-ECA array...
Glassy carbon is a graphenic form of elemental obtained from pyrolysis carbon-rich precursor polymers that can be patterned using various lithographic techniques. It electrically and thermally conductive, mechanically strong, light, corrosion resistant easy to functionalize. These properties render it very suitable for Carbon-microelectromechanical systems (Carbon-MEMS) nanoelectromechanical (Carbon-NEMS) applications. Here we report on the fabrication characterization fully operational,...
3D direct laser writing based on two-photon polymerization is considered as a tool to fabricate tailored probes for atomic force microscopy. Tips with radii of 25 nm and arbitrary shape are attached conventionally shaped micro-machined cantilevers. Long-term scanning measurements reveal low wear rates demonstrate the reliability such tips. Furthermore, we show that resonance spectrum probe can be tuned multi-frequency applications by adding rebar structures cantilever.
Carbon based bioMEMS are an emerging class of miniaturized biomedical devices. Due to the numerous advantages such as scalable manufacturing processes, inexpensive and readily available precursor polymer materials, tunable surface properties biocompatibility, carbon has become a preferred material for wide variety future biosensing applications. In this article, we review fabrication methodologies carbon-MEMS (CMEMS) carbon-NEMS (CNEMS) devices strategies their modification biocompatibility...