A5102962718- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
- Plasmonic and Surface Plasmon Research
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Analytical chemistry methods development
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Ferroptosis and cancer prognosis
- Mine drainage and remediation techniques
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Sulfur Compounds in Biology
- Orbital Angular Momentum in Optics
- Minerals Flotation and Separation Techniques
- Electrochemical Analysis and Applications
- Alzheimer's disease research and treatments
- Virus-based gene therapy research
- Advanced ceramic materials synthesis
- Inflammasome and immune disorders
Sichuan University
2025
Central South University
2013-2024
Chongqing Cancer Hospital
2020-2024
Chongqing University
2020-2024
Silicon Austria Labs (Austria)
2023
Shanxi University
2019-2020
University of Electronic Science and Technology of China
2020
Third Xiangya Hospital
2015
Southwest Minzu University
2013
Chongqing University of Posts and Telecommunications
2013
<h3>Objective:</h3> To identify the underlying genetic cause in a consanguineous Chinese family segregating distal hereditary motor neuropathy (dHMN) an autosomal recessive pattern. <h3>Methods:</h3> We used whole-exome sequencing and homozygosity mapping to detect variant 2 affected individuals of with dHMN. RNA analysis peripheral blood leukocytes immunofluorescence immunoblotting stable cell lines were performed support pathogenicity identified mutation. <h3>Results:</h3> 3 shared novel...
The optical vortex on a chip is of extreme importance for many applications in nanoscience, and as well-known, the chiral metallic nanostructures like plasmonic lenses (PVLs) can produce spin-dependent (PV) which governed by spin–orbit coupling. well-established nanophotonic theory various experimental demonstrations all show single PV mode one PVL, when excitation fixed. Here, counterintuitively, we report existence nontrivial deuterogenic PVs, besides predicted previously. We theoretically...
Ischemic stroke is a leading cause of death and disability worldwide, autophagy may be involved in the pathological process cerebral ischemia/reperfusion injury. Hydrogen sulfide (H 2 S) an endogenous gasotransmitter with protective effects against multiple diseases. Here, we tested effect H S on injury rats. Sodium hydrosulfide (Na HS ), donor, improved neurological function reduced size infarcts induced by transient middle artery occlusion ( MCAO ) followed reperfusion Na treatment lactate...
Chemotherapy is a standard strategy for glioma, while chemoresistance remains major therapeutic challenge in current clinical practice. Our present study was aimed to determine whether inhibition of the miR-223/paired box 6 (PAX6) pathway could increase sensitivity glioma Temozolomide. An elevated level miR-223 observed tissues. Exogenous promoted cell survival when exposed Temozolomide (TMZ), reverse this process. The RNA and protein levels PAX6 were significantly decreased by exogenous...
Nanotechnology has brought new approaches for the treatment of antibiotics, which are potent pollutants to water. In this study, we reported that a porous graphene oxide–chitosan aerogel (PGO-CS) could be used as recyclable adsorbent tetracycline removal. PGO-CS adsorbed with capacity around 1.47 × 103 mg g−1, ranking it among most effective adsorbents tetracycline. The adsorption equilibrium was well fitted Temkin model b value 2.83 10−3 kJ mol−1. kinetics described by pseudo-first-order...
Objective To investigate the influencing factors of inpatients giving red packets to doctors and explore necessity doctor-patient packet agreements. Methods A questionnaire survey was conducted among their families who were hospitalized in several hospitals Chengdu from January June 2023. The asked about patients’ (or families’) attitudes opinions on whether it necessary give during hospitalization. Results vast majority patients (80.7%) thought that not doctors, 87.0% had never given...
Accurate and rapid blood typing plays a vital role in variety of biomedical forensic scenarios, but recognizing weak agglutination remains challenging. Herein, we demonstrated flipping identification with prompt error-discrimination (FLIPPED) platform for automatic group readouts. Bromocresol green dye was exploited as characteristic chromatography indicator the differentiation plasma from whole by presenting teal color against brown color. After integrating these changes into quick-response...
Glioblastoma is one of the most common fatal intracranial malignancies. Lysine-specific demethylase 1 (LSD1) reportedly has therapeutic effects on a variety tumors. This study explored effect LSD1 inhibition glioblastoma cell lines and possible underlying mechanisms.
Abstract Aims In recent years, the incidence rate of hypertensive intracerebral haemorrhage (HICH) has been increasing, accompanied by high mortality and morbidity, which brought a heavy burden to social economy. However, pathogenesis HICH is still unclear. This study intends explore mechanism gut microbiota metabolism inflammation in process provide theoretical basis for diagnosis treatment HICH. Methods Results HE staining showed that brain tissues model group had obvious oedema injury,...
Abstract Background As a new type of regulatory cell death, ferroptosis has been proven to be involved in cancer pathogenesis and therapeutic response. However, the detailed roles or ferroptosis‐associated genes glioma remain clarified. Methods Here, we performed TMT/iTRAQ‐Based Quantitative Proteomic Approach identify differentially expressed proteins between specimens adjacent tissues. Kaplan–Meier survival was used estimate values. We also explored abnormally formin homology 2...
A new diarylheptanoid analogue-bearing sesquiterpene moiety, named Alpinisin A, was isolated from the rhizomes of Alpinia officinarum Hance. The structure determined by various spectroscopic techniques 1H-nuclear magnetic resonance (1H NMR), 13C-attached proton test (13C-APT), heteronuclear single quantum coherence (HSQC), multiple bond correlation (HMBC), 1H-1H spectroscopy (1H–1HCOSY), nuclear overhauser effect (NOESY) and high resolution electrospray ionization mass spectrometry...
Background: The commonly used therapeutic approach, the contemporary Bobath approach (CBA), is not sufficient to restore independent locomotion for individuals with severe motor deficit (SMD) after stroke. Therefore, we propose that early sitting, standing, and walking in conjunction CBA (ECBA) be treat SMD Objective: To investigate whether ECBA may enhance mobility balance subjects Methods: Thirty-three men 15 women, aged 60 74 years, stroke were recruited study. or was performed 5 times...
Abstract Real‐time quantitative monitoring of miRNAs plays an essential role in diagnosis and therapeutics. Herein, a DSN‐coupled graphene nanoarray/gold nanoparticles (GNAs/AuNPs) carbon paper (CP) electrode for the dynamic, sensitive, real‐time analysis is reported. GNAs are vertically grown on conductive CP by radio frequency plasma enhanced chemical vapor deposition, AuNPs electrodeposited CP/GNAs to build 3D ultrasensitive sensing interface with large specific surface area, good...
Background/Aims: Propofol, a widely used sedative-hypnotic agent for induction/maintenance of anesthesia and sedation critically ill patients, reportedly has therapeutic potential hypertension. Angiotensin-converting enzyme 2 (ACE2) is promising target pulmonary arterial In the present study, we explored effect propofol on ACE2 expression in human artery endothelial cells (HPAECs). Methods: HPAECs were treated with different concentrations (1, 10, 20, 40 or 50 µmol/l) lengths time (6, 12,...