A5033369277- Cell death mechanisms and regulation
- Protein Kinase Regulation and GTPase Signaling
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Signaling Pathways in Disease
- Cancer-related Molecular Pathways
- Glycosylation and Glycoproteins Research
- Computational Drug Discovery Methods
- NF-κB Signaling Pathways
- Proteoglycans and glycosaminoglycans research
- Venomous Animal Envenomation and Studies
- Retinoids in leukemia and cellular processes
- MicroRNA in disease regulation
- Skin and Cellular Biology Research
Lund University
2014-2022
Medicon Village
2016-2022
Cornell University
2001
Breast cancer prognosis is frequently good but a substantial number of patients suffer from relapse. The death receptor ligand TRAIL can in combination with Smac mimetics induce apoptosis some luminal-like ER-positive breast cell lines, such as CAMA-1, not MCF-7 cells. Here we show that and the mimetic LCL161 non-canonical NF-κB IFN signaling cells CAMA-1 when blocked by caspase inhibition. Levels p52 are increased STAT1 gets phosphorylated. phosphorylation induced alone independent since...
There is a need for novel strategies to initiate cancer cell death. One approach the use of Smac mimetics, which antagonize inhibitor apoptosis proteins (IAPs). Recent studies have shown that combinations mimetics such as LBW242 or LCL161 in combination with chemotherapeutic agents increase Here we show protein kinase C (PKC) activator TPA together mimetic induces death two basal breast lines (MDA-MB-468 and BT-549) are resistant single agent. Ten other LBW242-insensitive were not influenced...
Protein kinase C δ (PKCδ) is known to be an important regulator of apoptosis, having mainly pro- but also anti-apoptotic effects depending on context. In a previous study, we found that PKCδ interacts with the pro-apoptotic protein Smac. Smac facilitates apoptosis by suppressing inhibitor proteins (IAPs). We previously established PKCδ-Smac complex dissociates during induction indicating functional importance. Because knowledge molecular determinants interaction limited, aimed at...
Chondroitin sulfate (CS)/dermatan (DS) proteoglycans are abundant on the cell surface and in extracellular matrix have important functions structure, cell-matrix interaction signaling. The DS epimerases 1 2, encoded by Dse Dsel, respectively, convert CS to a CS/DS hybrid chain, which is structurally conformationally richer than CS, favouring with proteins growth factors. We recently showed that Xenopus essential for migration of neural crest cells allowing adhere fibronectin. Here we...
Breast cancer is the most common malignancy affecting women. Although prognosis generally good, a substantial number of patients still suffer from relapse, emphasizing need for novel treatments. Smac mimetics were developed to facilitate cell death by blocking inhibitor apoptosis proteins (IAPs). It has been suggested that TNF-related inducing ligand (TRAIL) can be used together with induce death. Cell viability was studied Trypan blue staining and Annexin V assay, siRNA downregulate...
Abstract There is a need for novel strategies to initiate cancer cell death. One approach the use of Smac mimetics, such as LBW242, which antagonize inhibitor apoptosis proteins (IAP)s and facilitates Recent studies have shown that combinations mimetics chemotherapeutic agents increase Here we show protein kinase C (PKC) activator TPA together with LBW242 induce death in two basal breast lines (MDA-MB-468 BT549), are resistant single agent. Eleven other LBW242-insensitive were not influenced...