A5025877188- Genomics and Chromatin Dynamics
- Engineering and Materials Science Studies
- RNA Research and Splicing
- Plant Molecular Biology Research
- Model-Driven Software Engineering Techniques
- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
Institute for Systems Biology
2023-2024
New York University
2023-2024
Cys2His2 zinc finger (ZF) domains engineered to bind specific target sequences in the genome provide an effective strategy for programmable regulation of gene expression, with many potential therapeutic applications. However, structurally intricate engagement ZF DNA has made their design challenging. Here we describe screening 49 billion protein-DNA interactions and development a deep-learning model, ZFDesign, that solves any genomic target. ZFDesign is modern machine learning method models...
The transfer of regulatory information between distal loci on chromatin is thought to involve physical proximity, but key biophysical features these contacts remain unclear. For instance, it unknown how close and for long two need be in order productively interact. main challenge that currently impossible measure dynamics with high spatiotemporal resolution at scale. Polymer simulations provide an accessible rigorous way test models regulation, yet there a lack simple general methods...
The transfer of regulatory information between distal loci on chromatin is thought to involve physical proximity, but key biophysical features these contacts remain unclear. For instance, it unknown how close and for long two need be in order productively interact. main challenge that currently impossible measure dynamics with high spatiotemporal resolution at scale. Polymer simulations provide an accessible rigorous way test models regulation, yet there a lack simple general methods...
The transfer of regulatory information between distal loci on chromatin is thought to involve physical proximity, but key biophysical features these contacts remain unclear. For instance, it unknown how close and for long two need be in order productively interact. main challenge that currently impossible measure dynamics with high spatiotemporal resolution at scale. Polymer simulations provide an accessible rigorous way test models regulation, yet there a lack simple general methods...
Abstract The transfer of regulatory information between distal loci on chromatin is thought to involve physical proximity, but key biophysical features these contacts remain unclear. For instance, it unknown how close and for long two need be in order productively interact. main challenge that currently impossible measure dynamics with high spatiotemporal resolution at scale. Polymer simulations provide an accessible rigorous way test models regulation, yet there a lack simple general...