A5023842343- Aldose Reductase and Taurine
- Prenatal Substance Exposure Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Barrier Structure and Function Studies
- Biochemical effects in animals
- Hormonal Regulation and Hypertension
- Hormonal and reproductive studies
- Cannabis and Cannabinoid Research
- Neurological Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Prostate Cancer Treatment and Research
- Cardiac Ischemia and Reperfusion
- Immune Response and Inflammation
- Connexins and lens biology
- Genomics, phytochemicals, and oxidative stress
- Metabolism and Genetic Disorders
- Cancer-related molecular mechanisms research
- Sepsis Diagnosis and Treatment
- Caveolin-1 and cellular processes
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
Gifu University
2008-2025
Gifu Pharmaceutical University
2015-2024
Chiba University
2011-2024
Teikyo University Chiba Medical Center
2024
RIKEN
2024
Technical University of Munich
2022
Hiratsuka Kyosai Hospital
2017-2021
Keio University
2015-2019
Ebara Hospital
2018
The University of Tokyo
2018
Claudin-2 is highly expressed in human lung adenocarcinoma tissues and cells. Knockdown of claudin-2 decreases cell proliferation migration. may be a novel target for adenocarcinoma. However, there are no physiologically active substances foods which decrease expression. We here found that quercetin, flavonoid present fruits vegetables, time- concentration-dependently expression A549 In the study, we examined what regulatory mechanism involved by quercetin. was decreased LY-294002,...
The human aldo-keto reductase AKR1B10, originally identified as an aldose reductase-like protein and small intestine reductase, is a cytosolic NADPH-dependent that metabolizes variety of endogenous compounds, such aromatic aliphatic aldehydes dicarbonyl some drug ketones. enzyme highly expressed in solid tumors several tissues including lung liver, has received considerable interest relevant biomarker for the development those tumors. In addition, AKR1B10 been recently reported to be...
Claudin-2 is highly expressed in human lung adenocarcinoma tissues and may be a novel target for cancer chemotherapy because knockdown of claudin-2 decreases cell proliferation. We found that flavonoids including kaempferol, chrysin, luteolin concentration-dependently decrease expression A549 cells. up-regulated by mitogen-activated protein kinase (MEK)/ extracellular signal-regulated (ERK)/c-Fos phosphoinositide 3-kinase (PI3K)/Akt/nuclear factor-κB (NF-κB) pathways, but these activities...
A novel photocatalysis to construct the 3-acyl-4-arylcoumarin framework from simple aldehyde with ynoate is described. The reaction proceeded through an acyl radical intermediate generated by hydrogen atom abstraction aldehyde, followed and then cyclization afford coumarins. This valuable gave over 20 coumarin derivatives in moderate good yields inexpensive 2-tBu-anthraquinone as a catalyst. In addition, synthetic coumarins were investigated for 5α-dihydrotestosterone (DHT)-induced secretion...
This study assessed the indications for and limitations of endoscopic mucosal resection (EMR) early colorectal cancer, focusing on way in which lesion lifts after submucosal injection.The included 94 patients with cancer who received EMR treatment. The lifting injection was analyzed (classified as completely lifted/soft; lifted/hard; incompletely lifted; non-lifted) along findings, pathological clinical course.Almost all lifted/soft lesions were cancers. Some lifted/hard staged sm2. lifted...
Aconite poisoning was examined in five patients (four males and one female) aged 49 to 78 years old. The electrocardiogram findings were as follows: ventricular tachycardia fibrillation case 1, premature contraction accelerated idioventricular rhythm 2, AIVR 3, nonsustained cases 4 5. patient 1 given percutaneous cardiopulmonary support because of unstable hemodynamics, whereas the other treated with fluid replacement antiarrhythmic agents. main aconitine alkaloid each had a half-life that...
Background. Previous studies have indicated that serum selenium levels are decreased in hemodialysis patients. Selenium deficiency may contribute to an increased risk for death among Methods. A population-based prospective cohort study adult patients was conducted. total of 1041 were enrolled. Patients divided into quartile groups according levels. Mortality rates between the compared by log-rank test. Associations and cause-specific mortality risks examined Cox's regression model. Results....
A human member of the aldo-keto reductase (AKR) superfamily, AKR1B10, was recently suggested as a therapeutic target in treatment several types cancer. Due to its high sequence identity with aldose (AKR1B1), selective inhibition AKR1B10 compared AKR1B1 is required for development anticancer agents. In this study, we have examined by seven pentacyclic triterpenes (1–7) that show potential properties. Among them, oleanolic acid (1) found be most potent competitive inhibitor (inhibition...
Aldo–keto reductase (AKR) 1C3 catalyzes the synthesis of active androgens that promote progression prostate cancer. AKR1C3 also contributes to androgen-independent cell proliferation and survival through metabolism prostaglandins reactive aldehydes. Because its elevation in castration-resistant cancer (CRPC) tissues, is a promising therapeutic target for CRPC. In this study, we found novel potent inhibitor, N-(4-fluorophenyl)-8-hydroxy-2-imino-2H-chromene-3-carboxamide (2d), synthesized...
The skin wound healing process consists of hemostatic, inflammatory, proliferative, and maturation phases, with a complex cellular response by multiple cell types in the epidermis, dermis, immune system. Magnesium is mineral essential for life, although magnesium treatment promotes cutaneous healing, molecular mechanism timing action are unknown. This study, using human epidermal-derived HaCaT cells normal epidermal keratinocyte cells, was performed to investigate involved effect on healing....
Previous studies have shown that serine proteases and Rho‐associated kinase contribute to carbon ion radiation‐enhanced invasion of the human pancreatic cancer cell line PANC‐1. The results presented here show nitric oxide synthase (NOS) also plays a critical role in this process. Irradiation PANC‐1 cells promoted production (NO), which activated PI3K–AKT signaling pathway, while independently activating RhoA. Inhibition PI3K, kinase, protease alone or conjunction with NOS suppressed cells,...