A5064414660- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- dental development and anomalies
- Orthodontics and Dentofacial Orthopedics
- Bone Metabolism and Diseases
- Bone and Dental Protein Studies
- Temporomandibular Joint Disorders
- Bone health and treatments
- Oral and Maxillofacial Pathology
- Connective tissue disorders research
- Dental Radiography and Imaging
- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Voice and Speech Disorders
- Dental Implant Techniques and Outcomes
- Dental Trauma and Treatments
- Cancer-related gene regulation
- Oral microbiology and periodontitis research
- Genetic Syndromes and Imprinting
- Pregnancy-related medical research
- Genomic variations and chromosomal abnormalities
- Hydrogen embrittlement and corrosion behaviors in metals
Tokyo Medical and Dental University
2016-2025
The University of Tokyo
2019-2025
Fujirebio (Japan)
2023-2024
Institute of Science Tokyo
2024
Rakuwakai Otowa Hospital
2023
Pusan National University
2023
Sungkyunkwan University
2023
Samsung Medical Center
2023
Yokohama City University Medical Center
2019
Yokohama City University
2019
Abstract Purpose: Similar to osteoclastogenesis, angiogenesis is enhanced in the bone marrow myeloma parallel with tumor progression. We showed previously that cells and osteoclasts are mutually stimulated form a vicious cycle lead enhance both osteoclastogenesis growth. The present study was undertaken clarify whether cell-osteoclast interaction enhances there any mutual stimulation between angiogenesis. Experimental Design: Myeloma monocyte-derived were cocultured, angiogenic activity...
Mesenchymal stem cells (MSCs) are able to differentiate into several lineages including osteoblasts. The signaling mechanisms involved in the osteogenic differentiation of MSCs however not fully understood. We investigated role fibroblast growth factor receptor 2 (FGFR2) osteoblast committment and murine mesenchymal C3H10T1/2 stably transfected with wild type (WT) or activated FGFR2 due Apert S252W genetic mutation (MT). WT slightly increased, whereas MT strongly tyrosine phosphorylation,...
Caveolin-3, the muscle-specific isoform of caveolins, plays important roles in signal transduction. Dominant-negative mutations caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy 1C (LGMD1C) with loss caveolin-3. However, identification precise molecular mechanism leading to atrophy caveolin-3–deficient muscle has remained elusive. Myostatin, a member TGF-β superfamily, negatively regulates skeletal volume. Here we report that inhibited myostatin signaling by suppressing...
Orthodontic tooth movement is achieved by the remodeling of alveolar bone surrounding roots teeth. Upon application orthodontic force, osteoclastic resorption occurs on compression side bone, towards which teeth are driven. However, molecular basis for regulatory mechanisms underlying has not been sufficiently elucidated. Osteoclastogenesis regulated receptor activator nuclear factor-κB ligand (RANKL), postulated to be expressed cells roots. Here, we show that osteocytes critical source...
We investigated the roles of osteocytes in osteoclastic bone resorption during orthodontic tooth movement using transgenic mice which can be specifically ablated. Because these express receptor for diphtheria toxin on cell surfaces osteocytes, injection ablate their vivo. Injection into significantly increased number ablated alveolar compared with that wild-type or without injection. Increased numbers were observed from day 4 to 12 after bones as well cortical tibiae. applied force days...
The identification of causative genetic variants for hereditary diseases has revolutionized clinical medicine and an extensive collaborative framework with international cooperation become a global trend to understand rare disorders. Initiative on Rare Undiagnosed Diseases (IRUD) was established in Japan provide accurate diagnosis, discover causes, ultimately cures undiagnosed diseases. fundamental IRUD system consists three pillars: diagnostic coordination, analysis centers (IRUD-ACs), data...
Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein 3-kinase family that activates both c-Jun NH2-terminal and p38 pathways in response to inflammatory cytokines physicochemical stress. We report ASK1 deficiency mice results dramatic retardation wounding-induced hair regrowth skin. Oligonucleotide microarray analysis revealed expression several chemotactic activating factors for macrophages, as well macrophage-specific marker genes, was reduced skin wound...
Abstract This article proposes less‐invasive subperiosteal bone‐bonding devices capable of realizing rapid osseointegration and the acquisition fundamental knowledge required for their development. Three candidates were prepared: titanium rod specimens with a machined surface (Bare), hydroxyapatite (HAp) coating, hydroxyapatite/collagen (HAp/Col) nanocomposite coating. To investigate bone formation around these rods, each specimen was placed under periosteum male Sprague‐Dawley rat...
Chromothripsis is the massive but highly localized chromosomal rearrangement in response to a one-step catastrophic event, rather than an accumulation of series subsequent and random alterations. occurs commonly various human cancers thought be associated with increased malignancy carcinogenesis. However, causes consequences chromothripsis remain unclear. Therefore, identify mechanism underlying generation chromothripsis, we investigated whether could artificially induced by ionizing...
Hydrogen embrittlement of Ni-Ti superelastic alloy in a fluoride solution (0.2% APF) has been investigated by means tensile test (after immersion) and hydrogen thermal desorption analysis. Upon immersion, the strength decreased to critical stress level martensite transformation. immersed specimens appeared with peak at around 500 degrees C. The amount absorbed ranged from 100 1000 mass ppm when for 2 24 h. immersion led degradation mechanical properties due embrittlement. results present...
Abstract Studies on the role of interleukin-6 (IL-6) in bone metabolism have been accumulating. However, its effects osteoblasts are still unclear because results conflicting depending study models employed. We reasoned that these data due to variable expression levels membrane-bound IL-6 receptors (IL-6Rs). In present study, we found combination with soluble IL-6R (sIL-6R) consistently caused a marked elevation alkaline phosphatase and decrease proliferation human osteoblastic cell line...
Apert syndrome is an autosomal dominant disease characterized by craniosynostosis and bony syndactyly associated with point mutations (S252W P253R) in the fibroblast growth factor receptor (FGFR) 2 that cause FGFR2 activation. Here we investigated role of S252W mutation on osteoblastic differentiation. Osteoblastic cells derived from digital bone two patients showed more prominent alkaline phosphatase activity, osteocalcin osteopontin mRNA expression, mineralized nodule formation compared...
Extensive histological study revealed the impairment of bone remodeling caused by mechanical stress in OPN knockout mice a tooth movement system. Analysis promoter transgenic showed response element(s) 5.5-kb upstream region. These results were also obtained with primary cultured cells.Mechanical loading system changes architecture through stimulation action numbers molecules. Among them, we that osteopontin (OPN) plays an important role to rats experimental for movement. The indicate...
Differential expression of genes in human periodontal ligament (PDL) under mechanical stress, such as orthodontic force, is thought to be involved the remodeling PDL cells and tissues. However, little known about expressed stress.We employed microarray analysis assess, a comprehensive manner, gene profiles compressed by static force using an vitro three-dimensional culture system. Six were selected validated quantitative real-time polymerase chain reaction analysis, consistent with data.The...
To cite this article: Suda N, Hattori M, Kosaki K, Banshodani A, Kozai Tanimoto Moriyama K:Correlation between genotype and supernumerary tooth formation in cleidocranial dysplasiaOrthod Craniofac Res 2010;13:197–202 Structured Abstract Authors – K Introduction Cleidocranial dysplasia (CCD, MIM#119600), for which the responsible gene is RUNX2, a genetic disorder characterized by hypoplasia or aplasia of clavicles, patent fontaneles, short stature. Supernumerary teeth delayed eruption...