A5066096239- Axon Guidance and Neuronal Signaling
- Zebrafish Biomedical Research Applications
- Cytokine Signaling Pathways and Interactions
- Malaria Research and Control
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related gene regulation
- Neuroblastoma Research and Treatments
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- CAR-T cell therapy research
- Neurogenesis and neuroplasticity mechanisms
- Inflammasome and immune disorders
- Cancer Research and Treatments
- Chronic Myeloid Leukemia Treatments
- COVID-19 and Mental Health
- Acute Myeloid Leukemia Research
- Immune cells in cancer
- TGF-β signaling in diseases
- Escherichia coli research studies
- Acute Lymphoblastic Leukemia research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
The University of Queensland
2016-2023
Griffith University
2016-2021
Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe neurological manifestations, including precipitating cases probable Parkinson's disease. As microglial NLRP3 inflammasome activation major driver neurodegeneration, here we interrogated whether promote activation. Using transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) as COVID-19 pre-clinical model,...
The antitumor activity of the tea tree oil (TTO) derived product, Melaleuca Alternifolia Concentrate (MAC) was characterized mechanistically at molecular and cellular level. MAC analyzed for its anticancer against human prostate (LNCaP) breast (MCF-7) cancer cell lines growing in vitro. (0.02–0.06% v/v) dose-dependently induced intrinsic (mitochondrial) apoptotic pathway both LNCaP MCF-7 lines, involving increased mitochondrial superoxide production, loss membrane potential (MMP), caspase...
Dengue virus, an arbovirus, causes estimated 100 million symptomatic infections annually and is increasing threat as the mosquito range expands with climate change. epidemics are a substantial strain on local economies health infrastructure, understanding of what drives severe disease may enable treatments to help reduce hospitalizations. Factors exacerbating dengue debated, but gut-related symptoms much more frequent in than mild cases. Using mouse models infection, we have shown that...
ABSTRACT Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe neurological manifestations, including precipitating cases probable Parkinson’s disease. As microglial NLRP3 inflammasome activation major driver neurodegeneration, here we interrogated whether promote utilising model human monocyte-derived microglia. We identified isolates bind and enter microglia, triggering in...
We recently characterised the NUP98-HOXD13 (NHD13) mouse as a model of T-cell pre-leukaemia, featuring thymocytes that can engraft in recipient animals and progress to acute lymphoblastic leukaemia (T-ALL). However, loss this engraftment ability by deletion Lyl1 did not result any leukemogenesis activity. In present study, we observe NHD13 overexpress EPHA3, characterise thymocyte behaviour mice with EphA3, which show markedly reduced incidence T-ALL. Deletion EphA3 from does prevent...
Abstract Our recent study of a novel model T-ALL pre-leukemic stem cells, the NUP98-HOXD13 (NHD13) mouse, showed that abnormal self-renewal these cells was dependent on Lyl1 yet, when deleted, still developed. In present study, we observe thymocytes in mice also overexpress EphA3, and characterise NHD13-EphA3 −/− mice. retain their activity demonstrated by capacity to engraft following primary secondary transplants. Strikingly, fail upon third serial transplant, whereas NHD13 indefinitely....