A5006753387- Histone Deacetylase Inhibitors Research
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- GDF15 and Related Biomarkers
- Cytokine Signaling Pathways and Interactions
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Ovarian cancer diagnosis and treatment
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Immune cells in cancer
- Adenosine and Purinergic Signaling
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- PARP inhibition in cancer therapy
- Developmental Biology and Gene Regulation
- Immune Response and Inflammation
- Infectious Diseases and Mycology
- interferon and immune responses
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
Centre de Recherche en Cancérologie de Toulouse
2018-2023
Université de Toulouse
2019-2023
Centre National de la Recherche Scientifique
2020-2023
ideXlab (France)
2023
Inserm
2019-2023
Monash University
2016-2021
Université Toulouse III - Paul Sabatier
2020
University of Padua
2009-2018
Australian Centre for HIV and Hepatitis Virology Research
2016-2017
Peter MacCallum Cancer Centre
2014-2016
Resistance to chemotherapy is a major problem in cancer treatment, and it frequently associated with failure of tumor cells undergo apoptosis. Birinapant, clinical SMAC mimetic, had been designed mimic the interaction between inhibitor apoptosis proteins (IAPs) SMAC/Diablo, thereby relieving IAP-mediated caspase inhibition promoting cells. We show that acute myeloid leukemia (AML) are sensitive birinapant-induced death emricasan/IDN-6556 augments, rather than prevents, killing by birinapant....
The side population (SP), recently identified in several normal tissues and a variety of tumors based on its ability to extrude some fluorescent dyes, may comprise cells endowed with stem cell features. In this study, we investigated the presence SP epithelial ovarian cancer found it 9 27 primary tumor samples analyzed, as well 4 6 cultures from xenotransplants. one xenograft bearing large fraction were characterized detail. had higher proliferation rates, much less apoptotic compared non-SP...
Increased Notch1 activity has been observed in intestinal tumours, partially accomplished by β-catenin-mediated up-regulation of the Notch ligand Jagged-1. Whether further mechanisms activation exist and other receptors might be involved is unclear. Microarray data indicated that Notch3 transcript levels are significantly up-regulated primary metastatic CRC samples compared to normal mucosa. Moreover, protein was expressed at strong/moderate 19.7% 158 analysed, weak 51.2% samples. Intrigued...
Relapses driven by chemoresistant leukemic cell populations are the main cause of mortality for patients with acute myeloid leukemia (AML). Here, we show that ectonucleotidase CD39 (ENTPD1) is upregulated in cytarabine-resistant cells from both AML lines and patient samples vivo vitro. cell-surface expression activity increased upon chemotherapy compared diagnosis, enrichment CD39-expressing blasts a marker adverse prognosis clinics. High promotes cytarabine resistance enhancing...
Genetic alterations disrupting the transcription factor IKZF1 (encoding IKAROS) are associated with poor outcome in B lineage acute lymphoblastic leukemia (B-ALL) and occur >70% of high-risk BCR-ABL1+ (Ph+) Ph-like disease subtypes. To examine IKAROS function this context, we have developed novel mouse models allowing reversible RNAi-based control Ikaros expression established B-ALL vivo. Notably, leukemias driven by combined BCR-ABL1 suppression rapidly regress when endogenous is...
Several studies have revealed that endosomal sorting controls the steady-state levels of Notch at cell surface in normal cells and prevents its inappropriate activation absence ligands. However, whether this highly dynamic physiologic process can be exploited to counteract dysregulated signaling cancer remains unknown. T-ALL is a malignancy characterized by aberrant signaling, sustained activating mutations Notch1 as well overexpression Notch3, paralog physiologically subjected...
Survival of patients with acute myeloid leukemia (AML) can be improved by allogeneic hematopoietic stem cell transplantation (allo-HSCT) because the antileukemic activity T and natural killer cells from donor. However, use allo-HSCT is limited donor availability, recipient age, potential severe side effects. Similarly, efficacy immunotherapies directing autologous against tumor cells, including T-cell recruiting antibodies, chimeric antigen receptor therapy, immune checkpoint inhibitors are...
Abstract Acute myeloid leukemia (AML) is a malignancy of immature progenitor cells. AML differentiation therapies trigger maturation and can induce remission, but relapse prevalent its cellular origin unclear. Here we describe high resolution analysis therapy response in mouse model. Triggering this model invariably produces two phenotypically distinct mature lineages vivo. Leukemia-derived neutrophils dominate the initial wave clear rapidly do not contribute to residual disease. In...
ABSTRACT Relapses driven by chemoresistant leukemic cell populations are the main cause of mortality for patients with acute myeloid leukemia (AML). Here, we show that ectonucleotidase CD39 (ENTPD1) is upregulated in cytarabine (AraC)-resistant cells from both AML lines and patient samples vivo vitro . surface expression activity increased upon chemotherapy compared to diagnosis enrichment CD39-expressing blasts a marker adverse prognosis clinics. High promotes AraC resistance enhancing...
<div>Abstract<p>The side population (SP), recently identified in several normal tissues and a variety of tumors based on its ability to extrude some fluorescent dyes, may comprise cells endowed with stem cell features. In this study, we investigated the presence SP epithelial ovarian cancer found it 9 27 primary tumor samples analyzed, as well 4 6 cultures from xenotransplants. one xenograft bearing large fraction were characterized detail. had higher proliferation rates, much...
Supplementary Figure 1, Tables 1-5 from The Side Population of Ovarian Cancer Cells Is a Primary Target IFN-α Antitumor Effects
Supplementary Materials and Methods from The Side Population of Ovarian Cancer Cells Is a Primary Target IFN-α Antitumor Effects