A5087204640- Renal Diseases and Glomerulopathies
- Urological Disorders and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Acute Kidney Injury Research
- Potassium and Related Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Adolescent and Pediatric Healthcare
- Cell Adhesion Molecules Research
- Biomarkers in Disease Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Proteoglycans and glycosaminoglycans research
- Corneal Surgery and Treatments
- Renal cell carcinoma treatment
- Aldose Reductase and Taurine
- Celiac Disease Research and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Kidney Stones and Urolithiasis Treatments
- Pharmacological Effects and Toxicity Studies
- Dialysis and Renal Disease Management
- Liver physiology and pathology
- Chronic Kidney Disease and Diabetes
- Berberine and alkaloids research
- Ion Transport and Channel Regulation
- Caveolin-1 and cellular processes
- Apelin-related biomedical research
Hamamatsu University School of Medicine
2004-2011
Hamamatsu University
2007-2010
Fujieda Municipal General Hospital
2008
Objective Adiponectin (ADPN) has been shown to protect against cardiovascular disease for the general population with problematic metabolic syndrome. However, it remains unclear whether ADPN is associated mortality in patients on maintenance hemodialysis (HD). Methods, Patients or Materials We selected 85 HD [51 men/34 women; mean age, 64±2 years; underlying kidney diseases, diabetic nephropathy 36 (42.3%), chronic glomerulonephritis 29 (34.1%), hypertensive nephrosclerosis 10 (11.8%), and...
Background. We examined kinetics and characterization of regenerating proximal tubule (PT) cells after various degrees tubular injury in S3 segments PT assessed label-retaining slow cycling S3. Methods. was induced by different doses uranyl acetate (UA) injection into rats, initially PTs were identified vivo bromodeoxyuridine (BrdU)-labelling before sacrifice or on vimentin positivity. Next, the 3H-thymidine pulse/chase approach applied to early BrdU-labelling UA injection. Results. Low-dose...
Background. We examined whether dedifferentiation is necessary for cell division of proximal tubule (PT) cells after acute PT injury. Methods. Rats were injected with a low (0.2 mg/kg) or high (4 dose uranyl acetate (UA) to induce Proliferating labelled bromodeoxyuridine (BrdU) before sacrifice. Renal tissues by double labelling BrdU and megalin, aquaporin 1 (AQP1), Na + –K ATPase vimentin, immunoelectron microscopy BrdU+ cells. Results. Under normal conditions, positive the phenotype...
We previously reported that early regenerating cells found at the distal area of S3 segment nephron (designated as target cells) were label-retaining in uranyl acetate (UA)-induced acute renal failure (ARF) rats. In this study, we examined contribution these to repair after UA treatment. also discriminated from bromodeoxyuridine (BrdU)-label-retaining labeled under normal conditions and their capacity proliferate following a second insult resistance 5-fluorouracil (5-FU).Target tracked using...
A 53-year-old man with nephrotic syndrome and severe renal failure was diagnosed light- heavy-chain deposition disease (LHCDD) by biopsy. The patient had no monoclonal protein mild marrow plasmacytosis (6%), but plasma cells expressed CD19-CD56+ predominant kappa-chain, indicating cell dyscrasia. Conventional chemotherapy ineffective did not improve failure. High dose chemotherapy/peripheral blood stem transplantation (HDC/PBSCT) introduced even after hemodialysis to eliminate aberrant clone...
We reported the case of a 70-year-old woman with moderate renal failure due to anti-neutrophil cytoplasmic antibody-related glomerulonephritis who developed symptomatic water intoxication (serum Na: 108 mEq/L) following treatment oral low-dose cyclophosphamide (CY) (50mg/day). Estimated glomerular filtration rate was 29.5 mL/min/1.73 m2. She had drunk >2 L fluid in 12 h prior development cerebral oedema. This rare suggests that CY could be an occult cause patients chronic kidney disease...
58-year-old female was admitted to our hospital complaining isolated proteinuria of 1.7 g/day. Abdominal echography showed right-sided unilateral hydronephrosis, and computed tomography pointed out a tumor the right renal pelvis, suggesting cancer pelvis. The nephroureterectomy carried out. Pathological diagnosis urothelial carcinoma. Renal tissue revealed no apparent glomerulopathy with tubular atrophy, interstitial fibrosis, mildly-to-moderately mononuclear cell infiltration....