A5100652814- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cancer Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Organic Chemistry Cycloaddition Reactions
- Mitochondrial Function and Pathology
- Aquaculture disease management and microbiota
- Pharmacological Effects of Natural Compounds
- Ubiquitin and proteasome pathways
- Advanced biosensing and bioanalysis techniques
- Photoreceptor and optogenetics research
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Bioactive Compounds and Antitumor Agents
- Aquaculture Nutrition and Growth
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Chemical Reactions and Isotopes
- Traditional Chinese Medicine Studies
Tangshan Gongren Hospital
2013-2023
Qilu Hospital of Shandong University
2022
Northwestern Polytechnical University
2021
First Affiliated Hospital of Zhengzhou University
2021
Dongguan University of Technology
2018
Center for Excellence in Molecular Cell Science
2017
Chinese Academy of Sciences
2017
Shanghai Institutes for Biological Sciences
2017
Hebei Medical University
2013
Shandong University
2013
To improve the oral bioavailability of quercetin (Q) and achieve colon-specific release, a core–sheath electrospun fiber mat containing Q-loaded chitosan nanoparticle (Q-loaded EFM) was developed in this study. The first fabricated, its antioxidant activity as effective free Q. Then uniform EFM obtained using response surface methodology optimization, structure characterized by confocal laser scanning microscopy. In vitro release kinetics confirmed colon targeting profile, rate Q varied...
Mitochondria-targeted therapy is an alternative strategy for cancer and may overcome the problems of metastasis drug resistance that usually occur in conventional treatment. In this work, we demonstrate mitochondria-targeted delivery a cationic cyclometalated platinum(ii) complex, PIP-platin, cells. PIP-platin showed selective accumulation mitochondria exhibited toxicity against variety tumor cell lines. The were disrupted by along with generation reactive oxygen species, depolarization...
Protein therapy provides a powerful alternative to small-molecule-based therapy, especially on cellular targets that are normally considered be less druggable. Intracellular protein delivery, in particular, cell-type-specific manner, is still highly challenging. At present, few general strategies available for the robust and selective intracellular delivery of proteins. In this Letter, by using zeolitic imidazolate framework-8 (ZIF-8) as protein-encapsulated nanoparticles simultaneous doping...
Circular RNA (circRNA) hsa_circ_0077837 inhibits colorectal cancer. Our research studied the participation of in non-small cell lung cancer (NSCLC). Hsa_circ_0077837 and phosphatase tensin homolog (PTEN) expression paired non-cancer tissues from a total 64 NSCLC patients were with RT-qPCR. To evaluate prognostic value for NSCLC, these monitored 5 years. Expression PTEN cells overexpression was determined by RT-qPCR Western blot. The methylation gene transfected vector analyzed specific PCR...
Objective: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) holds promise for cancer therapy as it has unique capacity to selectively trigger apoptosis in cells. We reported here that paclitaxel sensitized gastric cells TRAIL-induced apoptosis. Methods: After drug exposure, rate and caspase activation were examined. Various proteins detected by western blot. Several interventions, including pharmacological inhibitors siRNA transfection used. The growth inhibition of tumors was...
Objective To study the apoptosis inducing effect of cell exogenous ceramide on human bladder cancer cells and mechanism.Methods Human T24 were treated with 10,20,40 μmol/L C2-ceramide (C2-cer),and observed by inverted microscope.The morphological changes apoptotic examined fluorescent staining acridine orange (AO).Flow cytometry (FCM) was used to detect rate,and Western blotting done change intracellular distribution factor (AIF).Results Under action C2-cer,significant appeared in cells.The...
Abstract BackgroundHepatocellular carcinoma (HCC) is one of the most commonly diagnosed malignant tumors in world, and its recurrence mortality rate are still high level. In recent years, more inhibitors against gene targets have been found to be beneficial survival. However, function homo-sapiens histone H3 associated protein kinase (GSG2) HCC has not completely understood. MethodsThe expression GSG2 tissues was detected by immunohistochemical staining. The lentivirus-mediated short hairpin...