A5004988924- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Lung Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Surgical Treatments
- Abdominal vascular conditions and treatments
- Gastrointestinal disorders and treatments
- Enhanced Recovery After Surgery
- Intestinal and Peritoneal Adhesions
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroblastoma Research and Treatments
- Head and Neck Cancer Studies
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- Vascular Anomalies and Treatments
Nara Medical University
2014-2024
Nara Medical University Hospital
2020
Hoshigaoka Medical Center
2015
Nara City Hospital
2011-2014
National Archives and Records Administration
2014
Nutritional status is one of the most important issues faced by cancer patients. Several studies have shown that a low preoperative nutritional associated with worse prognosis in patients various types cancer, including esophageal (EC). Recently, neoadjuvant chemotherapy (NAC) and/or radiotherapy been accepted as standard treatment for resectable advanced EC. However, NAC has potential to deteriorate patient. This study aimed evaluate prognostic significance EC who underwent NAC. We...
The aim of this study was to investigate the impact geriatric nutritional risk index (GNRI) on long-term outcomes in 137 esophageal squamous cell carcinoma (ESCC) patients who underwent curative esophagectomy. GNRI calculated from serum albumin value and body weight. cutoff set at 98. A multivariate analysis performed identify prognostic factors for overall survival (OS). mean preoperative 99.9 ± 7.8. Forty-five (32.8%) had a <98. significantly associated with tumor depth (p = 0.001), level...
The aim of this study was to evaluate the prognostic impact nutritional index (PNI) in patients with recurrent esophageal squamous cell carcinoma (ESCC). We retrospectively reviewed 76 ESCC who developed recurrence after curative subtotal esophagectomy at Nara Medical University Hospital between January 2001 and October 2016. PNI calculated as 10 × serum albumin (g/dl) + 0.005 total lymphocyte count (/mm3). cutoff value set 45. Multivariate analysis performed identify factors. mean 44.0 ±...
Background/Aim: Ring finger protein 126 (RNF126) belongs to the family of RING E3 ubiquitin ligases. Although RNF126 has been reported be overexpressed in several cancers, role gastric cancer remains unclear. Materials and Methods: We investigated expression 170 primary tissues by immunohistochemistry, explored its prognostic impact. The effect on proliferation cells was evaluated vitro. Results: significantly associated with tumor depth presence venous invasion. status identified as an...
Tripartite motif protein (TRIM) 32 belongs to the TRIM family, which is composed of RING finger, B-box and coiled-coil domains. TRIM32 has been reported function as an enzyme 3 ubiquitin ligase overexpressed in numerous types cancer. The present study evaluated clinical significance expression levels gastric current also investigated 142 patients with cancer using immunohistochemistry examined its importance potential a prognostic marker. Furthermore, was vitro. High were detected tissues....
This prospective study was undertaken to investigate whether preoperative oral nutritional supplementation (ONS) would increase the prognostic index (PNI) in gastric cancer patients undergoing gastrectomy. Before surgery for resectable cancer, Racol® NF (Otsuka Pharmaceutical Factory, Japan) administered orally at a recommended dose of 600 kcal/600 ml per day with PNI <48. The primary endpoint change PNI, which calculated as 10 × serum albumin (g/dl) + 0.005 total lymphocyte count (per mm3)....
Delayed gastric emptying (DGE) after distal gastrectomy (DG) followed by Roux-en-Y (R-Y) reconstruction is one of the most worrisome complications, and course DGE has not been completely elucidated. This retrospective study aimed to evaluate frequency DG R-Y for cancer identify risk factors its development. included 266 patients with who underwent between 2005 2016. We compared clinicopathological characteristics surgical procedures group non-DGE group. occurred in 24 patients. There were no...
This study aimed to investigate the prognostic significance of preoperative anemia in gastric cancer patients.The medical records 801 patients with who underwent gastrectomy at Nara Medical University hospital, were reviewed. Anemia was defined as a hemoglobin (Hb) level <10 g/dl. Multivariate analysis performed identify factors.The mean Hb 13.1 (SD=2.0). Sixty-four (8.0%) classified into anemic group. Anemic significantly older than nonanemic (p=0.007). associated cardiovascular disease...
An esophageal neuroendocrine carcinoma arising in Barrett's esophagus is extremely rare. Here, we report a case of an with well-differentiated adenocarcinoma component and review the literature.A 71-year-old man no symptoms was admitted to our hospital because detection esophagogastric junction tumor on regular upper endoscopy screening. Endoscopy revealed sliding hiatal hernia approximately 10 mm elevated mass at junction. Biopsy showed moderately differentiated tubular adenocarcinoma....
In the present paper, we show a rare case of large abdominal wall defect and enterocutaneous fistulas after tension free repair using prostheses for incisional hernia.The patient, 70-year-old man, had history hemicolectomy perforating colon cancer, complicated by hernia that was closed primarily but recurred. Three years later, repaired at time second colectomy Composix Kugel Patch. His course chronic postoperative wound infection with eventual development fistulas. The patient successfully...
Ring box protein-1 (RBX1) is an essential component of the S-phase kinase-associated protein, Cullin and F-box containing ubiquitin ligases. Overexpression RBX1 has been reported in several cancer types; however, little known regarding prognostic value role esophageal cancer. The present study examined 120 patients with (EC) who underwent curative esophagectomy 61 EC neoadjuvant combination chemotherapy docetaxel, cisplatin 5-fluorouracil (5-FU; DCF) using immunohistochemistry. All specimens...