A5041637235- Cancer-related Molecular Pathways
- Medical Imaging and Pathology Studies
- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Thyroid Cancer Diagnosis and Treatment
- S100 Proteins and Annexins
- Ear and Head Tumors
- Radiation Dose and Imaging
- Calpain Protease Function and Regulation
- Advanced Breast Cancer Therapies
- Radiology practices and education
- Congenital heart defects research
- Sarcoma Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Clusterin in disease pathology
- Ultrasound in Clinical Applications
- Cardiac tumors and thrombi
The Ohio State University
2021-2025
The Ohio State University Wexner Medical Center
2017-2024
Background: Medullary thyroid cancer (MTC) is a frequently metastatic tumor of the that develops from malignant transformation C-cells. These tumors most commonly have activating mutations within RET or RAS proto-oncogenes. Germline result in C-cell hyperplasia, and cause MTC pre-disposition disorder, multiple endocrine neoplasia, type 2A (MEN2A). Single-agent therapies for MTC, including vandetanib (VAN) cabozantinib all MTCs selpercatinib (SEL) RET-mutated lead to partial responses but are...
‘Superenhanced’ transcription of oncogenes by aberrant looping upstream enhancer elements to transcriptional regulatory regions is a mechanism oncogene overexpression. Non-selective cyclin-dependent kinase inhibitors (CDKi) that target transcriptionally CDKs, including CDK7, 9, 12, and 13, reduce mRNA levels superenhanced have activity against thyroid cancer cells. We hypothesized more specific CDKs would differential activities in cells may be suitable for further studies. selected cell...
Metastatic medullary thyroid cancer (MTC) is incurable and FDA-approved kinase inhibitors that include oncogenic RET as a target do not result in complete responses. Association studies of human MTCs murine models suggest the CDK/RB pathway may be an alternative target. The objective this study was to determine if CDKs represent therapeutic targets for MTC define mechanisms activity. Using cells are either sensitive or resistant vandetanib, we demonstrate palbociclib (CDK4/6 inhibitor)...
Background: The retinoblastoma (RB) transcriptional corepressor 1 protein functions to slow cell-cycle progression. Inactivation of RB by reduced expression and/or hyperphosphorylation allow for enhanced progression through the cell cycle. Murine models develop medullary thyroid carcinoma (MTC) after generalized loss RB. However, in MTC has only been evaluated a small number tumors, with differing results. objective this study was determine whether overexpression hyperphosphorylated predict...
Pleomorphic liposarcoma of the uterus (PLU) is an extremely rare disease with poor prognosis. Limited treatment options exist for these patients, and recurrence usually occurs rapidly within months initial diagnosis. Few case reports metastatic PLU are available in literature. We describe a 70-year-old woman who presented large ovarian mass on imaging negative serum tumor markers endometrial biopsy. Staging revealed localized disease. Surgical resection pathology. Immunohistochemistry was...
As ultrasound has gained popularity with improving technology and ease-of-use, a push been made to integrate into the medical school curriculum. Many institutions are reporting one- four-year integrated curricula augment anatomy pathophysiology teaching. Our goal was thyroid scanning session endocrinology block of our institution’s curriculum enhance student understanding pathophysiology. We conducted prospective, single-center cohort (pre-experimental) study evaluate performance knowledge...
Abstract Disclosure: A. Valenciaga: None. M.N. Rayan: S.W. Ing: Background: Parathyromatosis is a rare cause of hyperparathyroidism. It refers to numerous parathyroid tissue foci within the neck and mediastinum, arising from expansion embryologic or due dissemination cells during surgical resection abnormal glands. Here, we describe case patient who underwent multiple medical interventions manage recurrent hyperparathyroidism secondary parathyromatosis. Clinical Case: A 28-year-old male with...
Abstract Hypoparathyroidism (hypoPTH), sensorineural deafness, and renal dysplasia (HDR) syndrome is a rare autosomal dominant condition with approximately 200 cases published. HDR caused by variants of GATA binding protein 3 gene (GATA3), which encodes transcription factor, multiple types GATA3 reported. We present the case 76-year-old woman who was diagnosed hypoPTH when she aged 40 years transferred care to our institution. Further history elucidated presence deafness at age 1 year...
Ectopic parathyroid glands are not rare. They usually located between the mandible and mediastinum, localized with standard imaging modalities (99mTc-sestamibi subtraction scintigraphy 4D-CT). We report case of a 67-year-old woman severe hypercalcemia due to symptomatic primary hyperparathyroidism whose preoperative 99mTc-sestamibi 4D-CT scans were non-localizing. During 4-gland exploration, one hypercellular was excised, two normocellular parathyroids biopsied, bilateral low internal...