A5102818973- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Vitamin D Research Studies
- Systemic Lupus Erythematosus Research
- Bone Metabolism and Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Connective Tissue Growth Factor Research
- Bone health and treatments
- Dermatological and Skeletal Disorders
- Parathyroid Disorders and Treatments
- COVID-19 Clinical Research Studies
- Cancer Diagnosis and Treatment
- Infrared Thermography in Medicine
- Connective tissue disorders research
- Chronic Lymphocytic Leukemia Research
- Bone health and osteoporosis research
- Dermatological and COVID-19 studies
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Pulmonary Hypertension Research and Treatments
- Bone and Joint Diseases
- Cytokine Signaling Pathways and Interactions
- Body Contouring and Surgery
University of Foggia
2013-2023
Ospedali Riuniti di Foggia
2017
A reduced bone mineral density (BMD) is observed in several rheumatic autoimmune diseases, including Systemic Sclerosis (SSc); nevertheless, data concerning the possible determinants of loss this disease are not fully investigated. The aim study to evaluate relationship between BMD, body mass composition, skin sclerosis and serum Vitamin D levels two subsets SSc patients. 64 post-menopausal patients, classified as limited cutaneous (lcSSc) or diffuse (dcSSc) SSc, were studied. As control, 35...
Abstract Background Glucocorticoids (GC) modulate several regulators involved in the pathogenesis of bone changes rheumatoid arthritis (RA). Trabecular score (TBS) allows indirect assessment quality. The aim this study was to investigate effects GC on TBS and serum levels turnover patients with recent-onset RA. Materials methods Forty-seven subjects RA (< 6 months) were classified two groups, low (lGC) high (hGC) glucocorticoids, according glucocorticoid dose regimens. Bone mineral...
Limited data on myoglobin and infectious diseases are available. In this study, we evaluate the potential role of in predicting poor outcome patients with Sars-Cov2 pneumonia.One hundred twenty-one Sars-Cov 2 an average age 69.9 ± 13.2 years, symptoms duration 8.8 7.9 days were enrolled study. At admission, serum levels myoglobin, erythrocyte sedimentation rate, C reactive protein (CRP), procalcitonin, ferritin, creatine phosphokinase, creatinine, fibrinogen, d-dimers, lactic dehydrogenase,...
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation and synovitis which evolve into joint destruction deformity. Bone abnormalities are represented marginal bone erosions iuxta-articular generalized osteoporosis. Overactivation of osteoclasts along with dysregulation osteoblasts the key events. resorption mediated receptor activator nuclear factor (NF)-κB (RANK) ligand (RANK-L), responsible for differentiation, proliferation, activation...
<h3>Background</h3> Data concerning the relationship between Systemic Sclerosis (SSc) and alterations of Bone Mineral Density (BMD) are very conflicting. The established standard for measuring BMD is Dual X-ray Absorptiometry (DXA), but it does not provide any informations about bone microarchitecture, which a parameter difficult to evaluate in clinical practice essential define strength. Trabecular Score (TBS) new structural that can be obtained by DXA scanning related microarchitecture...
<h3>Background</h3> Janus kinase inhibitors (JAK-i) are increasingly used in the treatment of Rheumatoid Arthritis (AR). Hypertransaminasemia is one described side effects this class drugs. <h3>Objectives</h3> The aim study to evaluate possible hepatotoxicity, risk NAFLD onset, and reactivation HBV HCV patients with AR JAK-i therapy. <h3>Methods</h3> 78 (81%F) were enrolled an average disease duration 15±7 years, BMI 26±4. inclusion criteria age > 18 fulfillment ACR/EULAR 2010 for AR,...
<h3>Background</h3> The role of IL17 cells in the pathogenesis Systemic Sclerosis (SSc) has recently emerged, as it been reported that IL-17 is overproduced by T from peripheral blood and fibrotic lesions skin lungs SSc patients able to enhance proliferation fibroblasts <i>in vitro</i>. In latest years also anti-inflammatory, anti-apoptotic, anti-fibrotic effects Vitamin D have gained considerable attention hypothesized could a modulating effect on SSc. <h3>Objectives</h3> aim this study...
Introduction Fibromyalgia is characterized by skeletal muscle pain and axial stiffness, with elective multiple points of tenderness (tender points). According to scientific literature, the prevalence depression, anxiety a worse quality life higher in patients fibromyalgia. Trauma (sexual abuse physical aggression) has key role perception. Objectives To describe clinical characteristics fibromyalgia and/or autoimmune rheumatic diseases admitted O.O.R.R. Foggia (Department Rheumatology),...
<h3>Background</h3> Pulmonary arterial hypertension (PAH) represents one of the main clinical expression vascular changes in Systemic Sclerosis (SSc). Many and experimental evidences suggest that lung microvascular play a role pathogenesis idiopathic PAH (IPAH) also. <h3>Objectives</h3> The aim this study is to investigate presence capillaroscopic abnormalities patients with evaluate differences capillary naifold between IPAH SSc without PAH. <h3>Methods</h3> 37 subjects (of whom 17 PAH), 21...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
<h3>Background</h3> Low Vitamin D concentrations have been reported in several rheumatic autoimmune diseases, and represent a key factor determining the reduction of bone mass density (BMD) increased fracture risk patients. In Systemic Sclerosis (SSc), hypovitaminosis is frequently observed, although available data appear to be somewhat discordant. The origin SSc multifactorial includes reduced sun exposition, malnutrition, physical activity, pharmacological interactions. Nevertheless,...
<h3>Background</h3> Many cytokines may potentially play a relevant role in the pathogenesis of different aspects SSc, particularly fibrosis and endothelial injury. Some data suggest that substance P (SP) act an autocrine/paracrine manner to regulate vasoconstriction and/or immunologic inflammatory responses. VEGF MCP1, which are produced by cells, be involved vascular changes accumulation extracellular matrix SSc. <h3>Objectives</h3> The aim this study was determine expression Substance...
<h3>Background</h3> Rheumatoid arthritis (RA) is a systemic inflammatory disease which can lead to bone and joint damage including local erosion general osteoporosis. Dual X-ray Absorptiometry (DXA) the established standard for measuring Bone Mineral Density (BMD), but it does not provide any informations about microarchitecture, an essential parameter define strength. The Trabecular Score (TBS) new structural that be obtained by DXA scanning related microarchitecture provides data on...
<h3>Background</h3> Vitamin D exerts different extra-skeletal effects, including a positive effect on muscle function. Circulating levels of the 25 hydroxylated - 25(OH)D reflect body reserves; to reach optimal serum threshold, supplementation is often requested. The commonest represented by cholecalciferol (D3), but metabolite calcifediol (HyD) represents therapeutic alternative. <h3>Objectives</h3> aim study was evaluate efficacy calficediol compared various administration schedules in...