A5045054634- Chinese history and philosophy
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Ancient Mediterranean Archaeology and History
- Augmented Reality Applications
- Historical and Religious Studies of Rome
- Virtual Reality Applications and Impacts
- Virus-based gene therapy research
- Interactive and Immersive Displays
- Human Motion and Animation
- Complex Systems and Decision Making
- Japanese History and Culture
- Occupational Therapy Practice and Research
- Artificial Intelligence in Games
- RNA and protein synthesis mechanisms
- Dendrimers and Hyperbranched Polymers
- European history and politics
- Mental Health and Psychiatry
- Embodied and Extended Cognition
- ICT in Developing Communities
- Educational Games and Gamification
- Digital Games and Media
- Classical Studies and Legal History
- Cognitive Science and Mapping
Oldenburger Institut für Informatik
2020
University of Bremen
2017-2019
Ludwig-Maximilians-Universität München
2009-2012
Center for NanoScience
2009-2012
Osnabrück University
1994
Artificial oligo(ethylene amino) acids, together with selected natural amino acids and fatty acid modifications, have been used for the solid-phase-assisted synthesis of polymers precise sequence, topology, modifications (see picture). First proof-of-concept studies demonstrate high potential such in pDNA siRNA delivery. K=lysine, A=alanine. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset....
Although our understanding of RNAi and knowledge on designing synthesizing active safe siRNAs significantly increased during the past decade, targeted delivery remains major limitation in development siRNA therapeutics. On one hand, practical considerations dictate robust chemistry reproducibly providing precise carrier molecules. other multistep process requires dynamic multifunctional carriers substantial complexity. We present a monodisperse system, synthesized by solid phase supported...
Gene silencing mediated by small interfering RNA (siRNA) is a novel approach in the development of new cancer therapeutics. Polycations used for nucleic acid delivery still remain heterogeneous compounds, despite continuous progress polymer synthetic technologies. Here we report structural defined folic polyethylene glycol (PEG) siRNA conjugate accessible via click chemistry yielding monodisperse ligand-PEG-siRNA conjugate. The targeting ligand was synthesized solid phase supported peptide...
Augmented sandboxes have been used as playful and educative tools to create, explore understand complex models. However, current solutions lack interactive capabilities, missing more immersive experiences such exploring the sand landscape from a first person perspective. We extend interaction space of augmented into virtual reality (VR) offer VR-environment that contains landscape, which user designs via interacting with real while wearing head-mounted display (HMD). In this paper, we...
Small interfering RNA (siRNA) and other synthetic molecules are the new hope in field of therapeutic gene modulation. The successful use these nucleic acids medicine requires efficient delivery into right compartment target cells, which most applications is cytosol. For this purpose can be assembled with polymers peptides nanoparticles virus-like dimensions. Such nanosystems have to dynamic their characteristics effective at different steps extracellular intracellular delivery. They must...
Abstract Background HD O is a low molecular weight pseudodendrimer containing oligoethylenimine and degradable hexanediol diacrylate diesters. DNA polyplexes display encouraging gene transfer efficiency in vitro vivo but also limited stability under physiological conditions. This limitation must be overcome for further development into more sophisticated formulations. Methods were laterally stabilized by crosslinking surface amines via bifunctional crosslinkers, bioreducible...
Previsualization (previs) is an essential phase in the design process of narrative media such as film, animation, and stage plays. Digital previs can involve complex technical tasks, e.g. 3D scene creation, camera work, which require trained skills that are not available to all personnel involved creative decisions for production. Interaction techniques virtual reality (VR) enable users interact with content a natural way compared classical 2D interfaces. As first step, we developed VR based...
Künstliche Oligoethylenaminosäuren wurden zusammen mit natürlichen Aminosäuren und optional Fettsäuren zur Festphasen-basierten Synthese von Polymeren präziser Sequenz, Topologie Modifikation eingesetzt. Erste Konzeptstudien demonstrieren das große Potenzial solcher Polymere in der Transfektion pDNA siRNA.
Abstract Oligoribonucleotides containing isoguanosine ( 1,2‐dihydro‐2‐oxoadenosine; isoG; 1 ) were prepared. The building block 2 was synthesized using the (dimethylamino)methylidene residue as NH protecting group. monomethoxytrityl well dimethoxytrityl group introduced at OH–C(5′) (→ 5 and 6 ). Silylation of with triisopropylsilyl chloride formed 2′‐ O ‐blocked derivative 7 almost exclusively. Reaction PCl 3 /1,2,4‐1 H ‐triazole furnished phosphonate which used in solid‐phase synthesis...
The excellent article of Tramonti follows a previous one from the same author, issuing legacy Gregory Bateson and suggesting an “ecology psychotherapy”. It is concerned with another fundamental contributor to systems theory, Ludwig von Bertalanffy, provides sound basis for continued discussion Bertalanffy's general theory (GST). To encourage further research, this note meant initiate about concept elements that fundamentally differs underpinned in GST as also hypostasized article.
Abstract Background In everyday practice, we do not pay much attention to the words use. So usually become aware of an ontological difference between levels so‐called objects focused upon and person‐centredness. To elucidate this fundamental difference, contrast here person‐centred medicine (PCM) a corresponding use polycentric grid approach (PCG approach) with conventional impersonal, objectifying approach. The latter is typically depicted in orthogonal grids, such as charts lists. This way...
In an everyday private practice setting, regularly also existential topics will emerge from doctor-patient encounters. These are often questions of coping with life and lifestyle. To enable a thorough discussion such topics, implicit, sometimes explicit reference to philosophical background is needed. Philosophical concepts be used in this realm discussed. An individual patient-doctor interaction as example demonstrate the doctor's choice hermeneutical phenomenological concepts.
Centred around the thesis that for those engaged in clinical practice there are two worlds present parallel, this article defines characteristics of supposed second, qualitative world. Contrasting these to world as seen continuous metric dimensions space and time, we derive nature elements their coherent interaction, well rules governing dynamic elements' interactions.The second claimed exist turns out be made individual centred perspectival interaction. Its polycentric agency enacts...
INTRODUCTION: An important phase in the process of visual design for narrative media is previsualization (previs). Professionals use complicated 3D software applications that are not especially designed purpose previs which makes it difficult
The conflict between classical and prehistoric archaeologists in Germany has its roots the nineteenth century but became bitter with event of National Socialism. German Archaeological Institute struggled Amt Rosenberg that claimed exclusive competence for ‘Germanic’ archaeology. research programme on Italian ostrogothic Lombard artefacts carried out by Institute’s Roman branch supervised second secretary Nazi-activist Siegfried Fuchs can be interpreted as part this struggle. ‘Germanic...
Building 3D scenes for games can be a difficult task, especially beginners and other non-experts wanting to contribute their own ideas in an easy way. Tools map or world creation are often complex understand use, don't support the creative process of building scene, decouple design from player experience. To overcome these problems, we present First-Person Shooter (FPS) game level using mechanics all tasks, making more enjoyable while also providing direct experience work player's point...