A5103180029- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Industrial Automation and Control Systems
- Adipose Tissue and Metabolism
- Industrial Technology and Control Systems
- Intraperitoneal and Appendiceal Malignancies
- Spinal Cord Injury Research
- Drug Transport and Resistance Mechanisms
- Fatty Acid Research and Health
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Nerve injury and regeneration
- Belt Conveyor Systems Engineering
- Ovarian cancer diagnosis and treatment
- Aluminum Alloys Composites Properties
- Nanoparticle-Based Drug Delivery
- Sarcoma Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Occupational and environmental lung diseases
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Aeroelasticity and Vibration Control
- Adrenal and Paraganglionic Tumors
- Fibromyalgia and Chronic Fatigue Syndrome Research
Dalian Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Zhejiang University
2013-2024
Beijing Shijitan Hospital
2019-2023
Capital Medical University
2019-2023
Zhejiang Pharmaceutical College
2017-2023
University of Louisville Hospital
2023
Xuzhou Medical College
2023
Changhai Hospital
2021
Recent studies have demonstrated neuroinflammation and increased cytokine levels are associated with depression. Aware of the efficacy potential anti-inflammatory antioxidative activity proanthocyanidin, present study was designed to investigate effects proanthocyanidin on lipopolysaccharide (LPS)-induced depressive-like behavior in mice. In depressive tests, immobility time forced swimming test (FST) tail suspension (TST) when mice were administrated a single dose LPS (0.83mg/kg, i.p.),...
Despite progress in the design of advanced surgical techniques, stenosis recurs a large percentage vascular anastomosis. In this study, novel heparin-poloxamer (HP) hydrogel was designed and its effects for improving quality safety anastomosis were studied. HP copolymer synthesized structure confirmed by Fourier transform infrared spectroscopy (FTIR) nuclear magnetic resonance (1H-NMR). Hydrogels containing prepared their important characteristics related to application including gelation...
This study aims to explore the role of indoleamine-2,3-dioxygenase (IDO)/kynurenine (KYN) pathway tryptophan (TRY) metabolism in behavioral alterations observed hepatic encephalopathy (HE) rats. Expression levels proinflammatory cytokines were tested by QT-PCR and ELISA, IDOs Western blot, 5-hydroxytryptamine (5-HT), KYN, TRY, 3-hydroxykynurenine (3-HK), kynurenic acid (KA) different brain regions estimated using HPLC. Effects IDO direct inhibitor 1-methyl-l-tryptophan (1-MT) on cognitive,...
Objective: Our study was designed to investigate whether indoleamine-2,3-dioxygenase (IDO)-mediated kynurenine/tryptophan (KYN/TRP) pathway participates in the development of emotional deficits ethanol addiction/withdrawal mice. Methods: Expression proinflammatory factors including tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) were tested by enzyme linked immunosorbent assay (ELISA). The IDO levels hippocampus, cerebral cortex amygdala measured polymerase...
The aim of the present research was to investigate effects irisin, a skeletal muscle-derived myokine, on spinal cord injury (SCI) in rats and explore possible mechanisms. SCI model constructed male SD rats. irisin were assessed via behavior tests including Basso, Beattie, Bresnahan (BBB) scoring method inclined plane test, followed by histomorphology HE staining, Nissl transmission electron microscope examination. Biochemical analyses PCR, Western blots ELISA employed further evaluate...
Although probiotics have been shown to improve several mental-related diseases, their association with post-stroke depression (PSD) remains unclear. This research aimed investigate the effect of combined live Bifidobacterium, Lactobacillus, Enterococcus and Bacillus cereus tablets on PSD serum inflammatory factors.A total 400 stroke patients treated from January 2020 March 2022 in Shuyang Hospital were included randomly divided into two groups: The observation group (n = 200) control 200)....
Objective To evaluate the efficacy of triple sheath neuroendoscopic combination technique (TSNCT) compared to standard endoscopic hematoma removal and external ventricular drainage (EVD) for managing complete intraventricular hemorrhage (IVH) casting in patients with cerebral hemorrhage. Methods A retrospective analysis was conducted on five IVH treated at our institution between 2023 2024, including two TSNCT, removal, one EVD. Preoperative postoperative imaging, intraoperative video,...
The antidepressant-like effect of trans-astaxanthin, a compound present rich in algae, was evaluated through behavioral and neurochemical methods. Results showed that trans-astaxanthin treatment significantly decreased the immobility time force swim test tail suspension test, but did not influence locomotor activity. Trans-astaxanthin effectively antagonize hypothermia ptosis induced by reserpine. However, pre-treatment with para-chlorophenylalanine abolished anti-immobility test. These...
Traumatic spinal cord injury (SCI) results in paraplegia or quadriplegia, and currently, therapeutic interventions for axonal regeneration after SCI are not clinically available. Animal studies have revealed that glial cell-derived neurotrophic factor (GDNF) plays multiple beneficial roles neuroprotection, scarring remodeling, axon remyelination SCI. However, the poor physicochemical stability of GDNF, as well its limited ability to cross blood-spinal barrier, hampers development GDNF an...
Abstract The aim of this study was to investigate the role 17β‐estradiol (E2)‐mediated oestrogen receptor (ER) in modulating depressive‐like behaviours ovariectomy (OVX) mice and associated mechanisms. E2 administrated OVX mice. behaviour physiological changes including immobility time tail suspension test (TST) forced swimming (FST), levels serum E2, inflammatory mediators, oxidative stress factors, indoleamine2,3‐dioxygenase 1 (IDO1) neurotransmitters mediated by IDO1 activation were then...
Purpose To investigate the effect of ferulic acid (FA) on spinal cord injury (SCI)-induced motor dysfunction and to explore possible pharmacological mechanisms. Methods Adult male Wistar rats were used in our study. SCI was achieved by clipping T9 rat a vascular clip for 2 minutes. The function evaluated Basso, Beattie, Bresnahan scoring method (BBB) inclined plane test. Hematoxylin eosin (HE) staining, NISSL transmission electron microscopic examination evaluate alterations at histological...
This research was designed to determine the role of irisin in lipopolysaccharide (LPS)-induced endometritis female mice.Animals were randomly assigned into sham, sham + irisin, LPS, LPS (0.1, 1, 10 μg/kg), and compound C groups. Histological features expression AMPK, NF-κB, inflammatory mediators, oxidative stress markers compared among different groups.The results showed that resulted obvious uterus damage, meanwhile, mediators (COX-2, iNOS, IL-1β, IL-6, TNF-α), as well NF-κB uterine...