A5069207417- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Cervical Cancer and HPV Research
- Metastasis and carcinoma case studies
- PARP inhibition in cancer therapy
- BRCA gene mutations in cancer
- Cancer, Lipids, and Metabolism
- Sarcoma Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Gestational Trophoblastic Disease Studies
- Reproductive System and Pregnancy
- Testicular diseases and treatments
- Reproductive Biology and Fertility
- Estrogen and related hormone effects
- Ovarian function and disorders
- Cancer survivorship and care
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolomics and Mass Spectrometry Studies
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Venous Thromboembolism Diagnosis and Management
- Cancer therapeutics and mechanisms
Cukurova University
2015-2024
University Medical Center Utrecht
2021
Beijing Obstetrics and Gynecology Hospital
2020
Okmeydanı Eğitim ve Araştırma Hastanesi
2018
LBA5506 Background: Olaparib (ola) maintenance (mtx) improved outcomes in pts with newly diagnosed AOC and a BRCAm (DiSilvestro J Clin Oncol 2023;41:609–17) or bev homologous recombination deficiency (HRD+) tumors (Ray-Coquard Ann 2022: LBA29) response to 1L treatment, but an unmet need remains. Combining immune checkpoint inhibitor antiangiogenic agent PARP may enhance antitumor effect (Banerjee 529MO). The Phase III DUO-O trial (NCT03737643) evaluates PC + durva, followed by mtx durva ola,...
TPS5630 Background: The standard treatment for advanced EC is still platinum-based combination CT, regardless of the histology, molecular status and patient’s profile. However, patients are a particularly frail group patients, often with co-morbidities. Tolerance CT can be difficult induce long-term toxicities. In disease, MMRd/MSI-H tumors represent 15 to 20 % cases. Preclinical data suggest that these more resistant platinum. On other hand, anti-PD1 immunotherapy has shown impressive...
TPS5598 Background: Ovarian cancer (OC) is the leading cause of death from gynecologic cancers in US women. Despite high response rates to first-line treatment, ~70% patients (pts) relapse within 3 years and then remain largely incurable. First-line treatment needs be improved achieve long-term remission pts improve cure rate. The Phase III SOLO1 trial showed a meaningful clinical benefit for olap maintenance therapy newly diagnosed OC with BRCA mutation (Moore et al N Engl J Med 2018)....
The aim of the present study was to compare long-term outcomes laparotomy (LT) and laparoscopic surgery evaluate results according low, intermediate, high-risk groups endometrial cancer (EC).We identified 801 patients with EC these were classified as group 1, who underwent LT (n=515); 2, laparoscopy (LS) (n=286). Patient's demographics, clinical characteristics such stage, grade, histopathologic type, lymphovascular space invasion, myometrial lymph node involvement, risk groups, peri-...
In Brief We designed this prospective, randomized, double-blind study to compare the analgesic effectiveness and side effects of IV patient-controlled morphine, pethidine, tramadol for postoperative pain management. One-hundred-twenty-six ASA physical status I or II patients undergoing abdominal hysterectomy were randomly allocated receive IV-patient controlled morphine (M), pethidine (P), (T) analgesia. The cumulative consumption over 24 h was 25.7 ± 9.5 mg 266 90 320 10 tramadol. average...
The first version of ENGOT's Requirements for Trials Between Academic Groups and Industry Partners in Europe was published 2010. This update integrates the experiences made by ENGOT network cooperative group studies while performing, analyzing, publishing -among others - three large phase III trials. Furthermore, progress European legislation its impact on clinical have been considered this process.
The purpose of this study is to evaluate the prognostic role preoperative neutrophil lymphocyte ratio (NLR) and platelet (PLR) need for para-aortic lymphadectomy in patients with primary fallopian tube carcinoma (PFTC).Ninety-one a diagnosis PFTC were identified through gynecologic oncology service database six academic centers. Clinicopathological, surgical, complete blood count data collected.In univariate analysis, advanced stage, suboptimal surgery, NLR > 2.7 significant factors...