Mariano Tabios
A5006771738- SARS-CoV-2 and COVID-19 Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Protein Structure and Dynamics
- interferon and immune responses
- Enzyme Structure and Function
- Cellular transport and secretion
- RNA and protein synthesis mechanisms
- Heat shock proteins research
- Invertebrate Immune Response Mechanisms
- Molecular Communication and Nanonetworks
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Ubiquitin and proteasome pathways
- SARS-CoV-2 detection and testing
- Monoclonal and Polyclonal Antibodies Research
- Insect Resistance and Genetics
- Click Chemistry and Applications
University of California, San Francisco
2019-2023
Molecular Biology Consortium
2021
Howard Hughes Medical Institute
2019
Exelixis (United States)
2004-2005
Abstract The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but its exact functions, and the structural basis those remain unknown. Here, we report an atomic model for full-length obtained by combining cryo-electron microscopy with deep learning-based structure prediction from AlphaFold2. resulting reveals highly-conserved zinc ion-binding site, suggesting role RNA binding. Mapping emerging mutations variants on shows potential host-Nsp2 interaction regions....
The Hsp90 molecular chaperone collaborates with the phosphorylated Cdc37 cochaperone for folding and activation of its many client kinases. As kinases, kinase CRaf is activated by phosphorylation at specific regulatory sites. phosphatase PP5 dephosphorylates in an Hsp90-dependent manner. Although dephosphorylating has been proposed as a mechanism releasing Hsp90-bound here we show that bound kinases sterically inhibit dephosphorylation indicating release must occur before dephosphorylation....
Abstract The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset pathology Parkinson’s disease. Native monomeric αSyn exists in an intrinsically disordered ensemble interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, here we successfully target structural thereby identify novel drug-like that impact multiple pathogenic processes. Using a surface plasmon resonance high-throughput screen, is...
The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but its exact functions, and the structural basis those remain unknown. Here, we report an atomic model for full-length obtained by combining cryo-electron microscopy with deep learning-based structure prediction from AlphaFold2. resulting reveals highly-conserved zinc ion-binding site, suggesting role RNA binding. Mapping emerging mutations variants on shows potential host-Nsp2 interaction regions. Using...
Mutations that inactivate the retinoblastoma (Rb) pathway are common in human tumors. Such mutations promote tumor growth by deregulating G1 cell cycle checkpoint. However, uncontrolled progression can also produce new liabilities for survival. To uncover such Rb mutant cells, we performed a clonal screen Drosophila eye to identify second-site eliminate Rbf(-) but allow Rbf(+) cells survive. Here report identification of mutation novel highly conserved peptidyl prolyl isomerase (PPIase)...
Abstract The Hsp90 molecular chaperone collaborates with the phosphorylated Cdc37 cochaperone to maintain kinase proteostasis through folding and activation of its many client kinases. As kinases, CRaf is activated by phosphorylation at specific regulatory sites. phosphatase PP5 dephosphorylates but also in an Hsp90-dependent manner. Although dephosphorylating has been proposed as a mechanism for releasing Hsp90-bound here we show that bound kinases sterically inhibit dephosphorylation...
Abstract The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset pathology Parkinson’s disease. Native monomeric αSyn exists in an intrinsically disordered ensemble interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, here we successfully target structural thereby identify novel drug-like that impact multiple pathogenic processes. Using a surface plasmon resonance high-throughput screen, is...
The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset pathology Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, here we successfully target structural thereby identify novel drug-like that impact multiple pathogenic processes. Using a surface plasmon resonance high-throughput screen, is incubated with...