A5079269918- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Cancer Genomics and Diagnostics
- Plant and animal studies
- Biomedical Text Mining and Ontologies
- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- Nutrition, Genetics, and Disease
- BRCA gene mutations in cancer
- Melanoma and MAPK Pathways
- Ecology and Vegetation Dynamics Studies
- Scientific Computing and Data Management
- Bioinformatics and Genomic Networks
- Learning Styles and Cognitive Differences
- Colorectal Cancer Treatments and Studies
- Wikis in Education and Collaboration
- Hemoglobinopathies and Related Disorders
- Plant Ecology and Taxonomy Studies
- Systemic Sclerosis and Related Diseases
- Health Literacy and Information Accessibility
- Statistical Methods in Clinical Trials
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Genetic factors in colorectal cancer
Vanderbilt University
2014-2023
Vanderbilt-Ingram Cancer Center
2016-2022
American Association For Cancer Research
2021
Vanderbilt University Medical Center
2016-2019
Indiana University Bloomington
2006-2019
Chelsea and Westminster Hospital
1954
Genetic correlations between the sexes can constrain evolution of sexual dimorphism and be difficult to alter, because traits common both share same genetic underpinnings. We tested whether artificial correlational selection favoring specific combinations male female within families could change strength a very high between-sex correlation for flower size in dioecious plant Silene latifolia. This novel dramatically reduced two three lines fewer than five generations. Subsequent only on...
This perspective describes the motivation, development, and implementation of pathway-based content for My Cancer Genome, an online precision medicine knowledge resource describing clinical implications genetic alterations in cancer. As researchers uncover more about cancer pathogenesis, we are learning not only specific genes proteins involved but also how those interact with others along cell signaling pathways. has led clinicians to begin think therapy using a approach. To facilitate this...
Natural selection should favor the integration of floral traits that enhance pollen export and import in plant populations rely upon pollinators. If this is true, then phenotypic correlations between weaken self‐fertilizing groups do not require pollinator visitation to produce seed. We tested hypothesis Leavenworthia , a genus which there have been multiple independent losses sporophytic self‐incompatibility system found throughout Brassicaceae. In particular, we conducted phylogenetically...
As the role of genomics in health care grows, patients increasingly require adequate genetic literacy to fully engage their care. This study investigated a model for delivering consumer-friendly information improve understanding precision medicine using and learning style principles. My Cancer Genome (MCG), freely available cancer decision support tool, was used as testbed. MCG content on melanoma tumor mutation, BRAF V600E, translated 6th-grade reading level, incorporating multiple...
1 a.m. with a two-day history of sore throat, abdominal pains, and nausea.She was thin
The My Cancer Genome (MCG) knowledgebase and resulting website were launched in 2011 with the purpose of guiding clinicians application genomic testing results for treatment patients cancer. Both originally developed using a wiki-style approach that relied on manual evidence curation synthesis into cancer-related biomarker, disease, pathway pages summarized literature clinical audience. This required significant time investment each page, which limited scalability as field advanced. To...
Background: Precision medicine has resulted in increasing complexity the treatment of cancer. Web-based educational materials can help address needs oncology health care professionals seeking to understand up-to-date strategies. Objective: This study aimed assess learning styles and determine whether style-tailored lead enhanced learning. Methods: In all, 21,465 were invited by email participate fully automated, parallel group study. Enrollment follow-up occurred between July 13 September 7,...
Treatment options are limited beyond JAK inhibitors for patients with primary myelofibrosis (MF) or secondary MF. Preclinical studies have revealed that PI3Kδ inhibition cooperates ruxolitinib, a JAK1/2 inhibitor, to reduce proliferation and induce apoptosis of JAK2V617F-mutant cell lines.In phase I dose-escalation -expansion study, we evaluated the safety efficacy selective umbralisib, in combination ruxolitinib MF who had suboptimal response lost ruxolitinib. Enrolled subjects were...
Abstract Genetic covariance between two traits generates correlated responses to selection, and may either enhance or constrain adaptation. Silene latifolia exhibits potentially constraining genetic specific leaf area (SLA) flower number in males. Flower is likely increase via fecundity selection but the SLA increases mortality, under decrease dry habitats. We selected on trait combinations lines for four generations test whether could be reduced without significantly altering means. In one...
<div>Abstract<p>Purpose: Treatment options are limited beyond JAK inhibitors for patients with primary myelofibrosis (PMF), or secondary MF. Preclinical studies have revealed that PI3Kδ inhibition cooperates ruxolitinib, a JAK1/2 inhibitor, to reduce proliferation and induce apoptosis of <i>JAK2</i><sup>V617F</sup> mutant cell lines. Patients Methods: In phase I dose-escalation expansion study, we evaluated the safety efficacy selective inhibitor...
<p>Supplemental Tables S1-S9 Supplemental Figures S1-S2</p>
<p>Supplemental Tables S1-S9 Supplemental Figures S1-S2</p>
<div>Abstract<p>Purpose: Treatment options are limited beyond JAK inhibitors for patients with primary myelofibrosis (PMF), or secondary MF. Preclinical studies have revealed that PI3Kδ inhibition cooperates ruxolitinib, a JAK1/2 inhibitor, to reduce proliferation and induce apoptosis of <i>JAK2</i><sup>V617F</sup> mutant cell lines. Patients Methods: In phase I dose-escalation expansion study, we evaluated the safety efficacy selective inhibitor...
<p>Supplemental Tables S1-S9 Supplemental Figures S1-S2</p>
<div>AbstractPurpose:<p>Treatment options are limited beyond JAK inhibitors for patients with primary myelofibrosis (MF) or secondary MF. Preclinical studies have revealed that PI3Kδ inhibition cooperates ruxolitinib, a JAK1/2 inhibitor, to reduce proliferation and induce apoptosis of <i>JAK2</i><sup>V617F</sup>-mutant cell lines.</p>Patients Methods:<p>In phase I dose-escalation -expansion study, we evaluated the safety efficacy selective...
<p>Supplemental Tables S1-S9 Supplemental Figures S1-S2</p>
<p>Supplemental Tables S1-S9Supplemental Figures S1-S2</p>
<p>Supplemental Tables S1-S9Supplemental Figures S1-S2</p>
<div>AbstractPurpose:<p>Treatment options are limited beyond JAK inhibitors for patients with primary myelofibrosis (MF) or secondary MF. Preclinical studies have revealed that PI3Kδ inhibition cooperates ruxolitinib, a JAK1/2 inhibitor, to reduce proliferation and induce apoptosis of <i>JAK2</i><sup>V617F</sup>-mutant cell lines.</p>Patients Methods:<p>In phase I dose-escalation -expansion study, we evaluated the safety efficacy selective...