This study aims to prepare hybrid chitosan-alginate aerogel microparticles without using additional ionic crosslinker as a possible pulmonary drug delivery system. The were prepared the emulsion gelation method. effect of mixing order biopolymer within and surfactant used on final particle properties investigated. Physicochemical characterizations performed evaluate size, density, morphology, surface area, charge, crystallinity preparation. developed preparation was evaluated for its acute...

Abstract Renal (RIP) and hepatic (HIP) impairments are prevalent conditions in cancer patients. They can cause changes gastric emptying time, albumin levels, hematocrit, glomerular filtration rate, functional volume, blood flow rates, metabolic activity that modify drug pharmacokinetics. Performing clinical studies such populations has ethical practical issues. Using predictive physiologically‐based pharmacokinetic (PBPK) models the evaluation of PK alectinib, ruxolitinib, panobinostat...

To describe the increasing number of pharmacy schools in Jordan.A review for numbers and their curricula was conducted.To date, there are 18 Jordan. PharmD program is offered by two public schools. PhD one school; while MSc seven Public have similar programs terms curricula, 'regular' 'parallel'. The ratio pharmacists to 1000 population 2.1 2012. Substantial increase pharmacists' integration needed private primary care settings.Number graduates Jordan seems be 'high'. If remain on a track...

Opioid use disorder (OUD) during pregnancy is associated with high mortality rates and neonatal opioid withdrawal syndrome (NOWS). Buprenorphine, an opioid, used to treat OUD NOWS. Buprenorphine active metabolite (norbuprenorphine) can cross the placenta cause respiratory depression (EC 50 = 35 ng/mL) at brain extracellular fluid (bECF) levels. Neonatal therapeutic drug monitoring using saliva decreases likelihood of distress infections frequent blood sampling.

Abstract Background Mycophenolic acid (MPA) is used widely to prevent graft rejection in kidney‐transplant patients. Therapeutic drug monitoring (TDM) plasma requires an invasive procedure that inconvenient, especially pediatric TDM saliva a more convenient non‐invasive alternative compared with plasma. Methods A population physiologically based pharmacokinetic (Pop‐PBPK) model of mycophenolate mofetil (MMF) and MPA enterohepatic recycling was built verified using previously published...

The aim of this study was to investigate ketorolac (KT) systemic absolute bioavailability after sublingual (SL) administration in vivo conscious rabbits. Furthermore, the investigated potential use chitosan nanoparticles as a delivery system enhance KT following SL administration.Ketorolac-loaded were prepared through ionotropic gelation with tripolyphosphate anions. KT-nanoparticles administered spray rabbits and plasma concentration at predetermined time points compared solution....

Abstract Gentamicin has proven to be a very successful treatment for bacterial infection, but it also can cause adverse effects, especially ototoxicity, which is irreversible. Therapeutic drug monitoring (TDM) in saliva more convenient non-invasive alternative compared plasma. A physiologically-based pharmacokinetic (PBPK) model of gentamicin was built and validated using previously-published plasma data. The then used predict experimentally-observed TDM data Jordanian pediatric preterm...

Background: Atomoxetine is a treatment for attention-deficit hyperactivity disorder. It inhibits norepinephrine transporters (NET) in the brain. Renal impairment can reduce hepatic CYP2D6 activity and atomoxetine elimination which may increase its body exposure. be secreted saliva. Objective: The objective of this work was to test hypothesis that saliva levels (sATX) used predict ATX brain extracellular fluid (bECF) their pharmacological effects healthy subjects those with end-stage renal...

The unpleasant extremely bitter taste of the orally administered broad-spectrum antibiotic azithromycin decreases patient compliance, especially in pediatrics. This issue can be overcome by decreasing drug interaction with tasting buds using insoluble polymers at salivary pH (6.8 - 7.4), like cationic polymer Eudragit EPO. Supercritical fluid technology is a green synthesis method for preparing pharmaceutical preparations that replace organic solvents safe supercritical CO

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Bacterial skin and soft tissue infections (SSTIs) are widespread microbic invasions of the deeper tissues. Topical drug delivery systems most favored administration pathway when treating SSTIs. This is down to their minimal risk inducing systemic adverse events, reduced development bacterial resistance, ease application. However, they have several drawbacks, including lack control over release profile, irritations, limited permeability certain compounds through skin. To address these...

Despite the broad spectrum of antibiotic Azithromycin, its extremely bitter taste after oral dosing decreases patient compliance. This can be masked by minimizing Azithromycin interaction with tasting buds using polymers that are insoluble at salivary pH (6.8–7.4), like cationic Eudragit EPO and S100. The purpose this study was to employ two different techniques (solvent evaporation (SE) supercritical fluid technology (SFT)) for encapsulating into microparticles mask taste. formulations were...

Therapy failure caused by complex population-drug-drug (PDDI) interactions including CYP3A4 can be predicted using mechanistic physiologically-based pharmacokinetic (PBPK) modeling. A synergy between ritonavir-boosted lopinavir (LPVr), ivermectin, and chloroquine was suggested to improve COVID-19 treatment. This work aimed study the PDDI of two substrates (ivermectin chloroquine) with LPVr in mild-to-moderate adults, geriatrics, pregnancy populations.The ivermectin or investigated. Pearson's...

Renal impairment can affect the elimination of hepatically metabolized drugs. Bexarotene (BXT) used for cutaneous T-cell lymphoma is highly bound in plasma and by CYP3A4. The BXT European Medicine Agency Food Drug Administration packages recommended evaluation renal on metabolism. protein binding be changed patients with dysfunction due to hypoalbuminemia accumulation uremic toxins. In vitro, microsomal stability studies were pursued. A preclinical pharmacokinetic study was pursued control,...