A5052997276- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- Advanced biosensing and bioanalysis techniques
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
University of California, Irvine
2021-2022
Monoclonal antibodies are emerging as a viable treatment for the coronavirus disease 19 (COVID-19). However, newly evolved variants of severe acute respiratory syndrome 2 (SARS-CoV-2) can reduce efficacy currently available and diminish vaccine-induced immunity. Here, we demonstrate that microscopic dynamics neutralizing monoclonal be profoundly modified by mutations present in spike proteins SARS-COV-2 circulating world population. The dynamical perturbations within antibody structure,...
Abstract Monoclonal antibodies are emerging as a viable treatment for the coronavirus disease 19 (COVID-19). However, newly evolved variants of severe acute respiratory syndrome 2 (SARS-CoV-2) can reduce efficacy currently available and diminish vaccine-induced immunity. Here, we demonstrate that microscopic dynamics neutralizing monoclonal be profoundly modified by mutations present in spike proteins SARS-COV-2 circulating world population. The dynamical perturbations within antibody...