A5030818978- Galectins and Cancer Biology
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Chemotherapy-induced cardiotoxicity and mitigation
- ATP Synthase and ATPases Research
- Cell death mechanisms and regulation
- Anesthesia and Neurotoxicity Research
- Food Allergy and Anaphylaxis Research
- T-cell and Retrovirus Studies
- Toxin Mechanisms and Immunotoxins
- Endoplasmic Reticulum Stress and Disease
- Inhalation and Respiratory Drug Delivery
- Climate Change and Health Impacts
- Hematopoietic Stem Cell Transplantation
- Air Quality and Health Impacts
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Viral-associated cancers and disorders
- Acute Kidney Injury Research
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Peptidase Inhibition and Analysis
- Nanoparticle-Based Drug Delivery
- Cardiac Ischemia and Reperfusion
United Arab Emirates University
2009-2025
National Institute of Pathology
2011
Acute kidney injury (AKI) is a public health burden with increasing morbidity and mortality rates care costs. tubular necrosis (ATN) the most common cause of AKI. Cisplatin (CIS) platinum-based chemotherapeutic agent used in treatment wide variety malignancies such as lung, breast, ovary, testis, bladder, cervix, head neck cancers. Autophagy plays an important role Galectin-3 (Gal-3) significantly increased renal tubules AKI; however, its autophagy not well understood. Male C57B6/J...
Renal ischemia-reperfusion injury (IRI) is an inevitable consequence of several clinical conditions and surgical procedures including renal transplantation resuscitation following systemic hypotension. It leads to immediate dysfunction might result in long-term damage. Therefore, there ongoing effort mitigate the deleterious effects IRI on kidney. Recently, has been a recent interest using natural compounds as alternative remedies many diseases. Thus, aim this research was study effect...
We report on the pneumatocyte structure and function of mouse lung specimens exposed in vitro to two calcined mesoporous silica particles, MCM41-cal (spheres, ∼300 1000 nm diameter) SBA15-cal (irregular rods averaging ∼500 diameter ∼1000 length). These particles are consideration for potential medical application as delivery vehicles genes, drugs, bio-imagers. In study, (about 10 mg each) were excised from male Balb/c mice, immediately immersed Krebs-Henseleit buffer, ice-cold, continuously...
Doxorubicin (DOXO) is a potent chemotherapeutic drug that used in the treatment of large number cancers. Despite its important characteristics, usage limited because serious side effects; most noticeable cardiotoxicity which can manifest acutely or years after completion leading to left ventricular dysfunction, dilated cardiomyopathy and heart failure. Nootkatone (NK) recognized bioactive compound isolated from heartwood Cupressus nootkatensis has been reported have antiseptic, antioxidant,...
Doxorubicin (DOXO) is an effective drug that used in the treatment of a large number cancers. Regardless its important chemotherapeutic characteristics, usage restricted because serious side effects; most obvious cardiotoxicity, which can manifest acutely or years after completion treatment, leading to left ventricular dysfunction, dilated cardiomyopathy, and heart failure. Galectin 3 (Gal-3) beta galactoside binding lectin has different roles normal pathophysiological conditions. Gal-3 was...
Breast carcinoma is the commonest cancer among UAE population and most common females. Examination of 5′ promoter regions trefoil factor 3 (TFF3) gene has identified putative estrogen progesterone receptor–DNA binding domains as direct response elements to that are linked breast functions or steroid regulation. The study was designed determine role TFF3 in chemoresistance with aim establishing expression a biomarker for drug resistance. In total, 133 cases treated neo-adjuvant therapy were...
BACKGROUND/AIMS: Acute kidney injury (AKI) is a public health burden with increasing morbidity, mortality and care cost. It associated increased risk for the development of chronic disease death. tubular necrosis (ATN) most common cause AKI. Apoptosis tissue play an important role in ATN. Galectin 3 (GAL-3), beta galactoside binding lectin, known to have inflammation, apoptosis oxidative stress but its cisplatin induced acute not clearly elucidated. METHODS: Male C57B6-J C57BL-6 -GAL-3...
Background: Cardiovascular diseases are the leading cause of death worldwide, including United Arab Emirates. Ischemia–reperfusion (IR) injury results in cardiac myocytes that were viable immediately before myocardial reperfusion. We aim to investigate role galectin-3 (Gal-3) autophagy during ischemia–reperfusion injuries. Methods: Male C57B6/J and Gal-3 knockout (KO) mice used for murine model IR injury. Heart samples serum collected 24 h post-IR processed immunohistochemical...
Idelalisib, an inhibitor of the phosphatidylinositol-3-kinase p110δ subunit (PI3Kδ), is approved for treating lymphoid malignancy. The drug associated with hematopoietic and pulmonary toxicities, which limit its clinical use. However, toxicity mechanisms are not completely elucidated. In this study, mice were intraperitoneally injected idelalisib (40 or 80 µg/g) dimethyl sulfoxide five days every week up to four weeks evaluate changes in thymus, spleen, functions. Idelalisib treatment...
// Suhail Al-Salam 1 , Karthishwaran Kandhan and Manjusha Sudhadevi Department of Pathology, College Medicine & Health Sciences, United Arab Emirates University, AlAin, UAE Correspondence to: Al-Salam, email: suhaila@uaeu.ac.ae Keywords: cancer metabolism; LDHA; apoptosis; VDAC Received: February 23, 2021     Accepted: March 25, Published: April 27, 2021 Copyright: © et al. This is an open access article distributed under the terms Creative Commons Attribution...
Anaphylactic shock (AS) is a life-threatening, multisystem disorder arising from sudden release of mast cell- and basophil-derived mediators into the circulation. In this study, we have used Wistar rat model to investigate AS-associated histopathologic changes in various organs. Rats were sensitized with ovalbumin (1 mg s.c), AS was induced by intravenous injection mg). Experimental groups included nonallergic rats (n = 6) allergic 6). Heart rate blood pressure monitored during one hour....