A5058292733- Spine and Intervertebral Disc Pathology
- Orthopaedic implants and arthroplasty
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Bone Tissue Engineering Materials
- Hip disorders and treatments
- Bone health and osteoporosis research
- Total Knee Arthroplasty Outcomes
- Pelvic and Acetabular Injuries
- Dental Implant Techniques and Outcomes
- Bone fractures and treatments
- Hip and Femur Fractures
- Scoliosis diagnosis and treatment
- Electrospun Nanofibers in Biomedical Applications
- Shoulder Injury and Treatment
- Osteoarthritis Treatment and Mechanisms
- Cervical and Thoracic Myelopathy
- Geophysics and Gravity Measurements
- Veterinary Orthopedics and Neurology
- Bone and Joint Diseases
- 3D Printing in Biomedical Research
- Orthopedic Infections and Treatments
- Orthopedic Surgery and Rehabilitation
- Lower Extremity Biomechanics and Pathologies
Institute for Biomedical Engineering
2016-2025
ETH Zurich
2016-2025
Lehigh University
2023
University of Zurich
2014-2023
Schulthess-Klinik
2020-2023
Uppsala University
2023
Swiss Federal Laboratories for Materials Science and Technology
2015-2021
AO Foundation
1996-2020
Institute of Molecular and Cell Biology
2020
Agency for Science, Technology and Research
2020
Study Design. The effect of cement augmentation on an osteoporotic lumbar functional spinal unit was investigated using finite-element analysis. Objective. To evaluate the influence load transfer, stresses, and strains. Summary Background Data. Osteoporosis is most frequent skeletal disease elderly, leading to weakness bony structures. Cement injection into vertebral bodies has been used treat compression fractures spine. clinical results are encouraging. Experimental biomechanical studies...
Vertebroplasty, which is the percutaneous injection of bone cement into vertebral bodies has recently been used to treat painful osteoporotic compression fractures. Early clinical results have encouraging, but very little known about consequences augmentation with for adjacent, non-augmented level. We therefore measured overall failure, strength and structural stiffness paired two-vertebra functional spine units (FSUs). One FSU each pair was augmented polymethylmethacrylate in caudal...
Abstract To make a direct biomechanical comparison between the sandblasted and acid‐etched surface (SLA) machined (MA), well‐established animal model for implant removal torque testing was employed, using split‐mouth experimental design. All implants had an identical cylindrical solid‐screw shape with standard ITI thread configuration, without any macroscopic retentive structures. After 4, 8, 12 weeks of bone healing, performed to evaluate interfacial shear strength each type. Results showed...
Abstract The functional capacity of osseointegrated dental implants to bear load is largely dependent on the quality interface between bone and implant. Sandblasted acid‐etched (SLA) surfaces have been previously shown enhance apposition. In this study, SLA has compared with a chemically modified (modSLA) surface. increased wettability modSLA surface in protein solution was verified by dynamic contact angle analysis. Using well‐established animal model split‐mouth experimental design,...
Abstract Soft tissue damage has been observed in hip joints with pathological geometries. Our primary goal was to study the relationship between morphological variations of bony components and resultant stresses within soft tissues joint during routine daily activities. The secondary find range parameters which are minimized. Computational models normal were developed based on femoral head (Alpha angle) acetabulum (CE angle). Alpha angle varied 40° (normal joint) 80° (cam joint). CE 0°...
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Tissue scaffolds provide structural support while facilitating tissue growth, but are challenging to design due diverse property trade-offs. Here, a computational approach was developed for modeling with lattice structures of eight different topologies and assessing properties relevant bone engineering applications. Evaluated include porosity, pore size, surface-volume ratio, elastic modulus, shear permeability. Lattice were generated by patterning beam-based unit cells, parameters beam...
Abstract Background In the present study, 4 different metallic implant materials, either partly coated or polished, were tested for their osseointegration and biocompatibility in a pelvic implantation model sheep. Methods Materials to be evaluated were: Cobalt-Chrome (CC), Cobalt-Chrome/Titanium coating (CCTC), Cobalt-Chrome/Zirconium/Titanium (CCZTC), Pure Titanium Standard (PTST), Steel, TAN (TANST) new finish (TANNEW). Surgery was performed on 7 sheep, with 18 implants per total of 63...
Degenerative joint disease (DJD) is a major cause of reduced athletic function and retirement in equine performers. For this reason, regenerative therapies for DJD have gained increasing interest. Platelet-rich plasma (PRP) mesenchymal stem cells (MSCs) were isolated from 6-year-old donor horse. MSCs either used their native state or after chondrogenic induction. In an initial study, 20 horses with naturally occurring the fetlock divided 4 groups injected following: 1) PRP; 2) MSCs; 3) 4)...
Although variation in effect sizes and predicted values among studies of similar phenomena is inevitable, such far exceeds what might be produced by sampling error alone. One possible explanation for results differences researchers the decisions they make regarding statistical analyses. A growing array has explored this analytical variability different (mostly social science) fields, found substantial results, despite analysts having same data research question. We implemented an analogous...