A5045053001- Carcinogens and Genotoxicity Assessment
- Nanoparticles: synthesis and applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Heavy Metal Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Sexual Differentiation and Disorders
- Frailty in Older Adults
- Nanoparticle-Based Drug Delivery
- Marine Toxins and Detection Methods
- Toxic Organic Pollutants Impact
- Chromosomal and Genetic Variations
- Nutrition and Health in Aging
- LGBTQ Health, Identity, and Policy
- Environmental Toxicology and Ecotoxicology
- DNA Repair Mechanisms
- Graphene and Nanomaterials Applications
- Glutathione Transferases and Polymorphisms
- Higher Education Teaching and Evaluation
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Sex and Gender in Healthcare
- E-Learning and Knowledge Management
- Selenium in Biological Systems
- Microplastics and Plastic Pollution
- Chemical Safety and Risk Management
Universidade da Coruña
2016-2025
Instituto de Investigación Biomédica de A Coruña
2020-2024
Complexo Hospitalario Universitario A Coruña
2020-2023
Servicio Gallego de Salud
2020
Center for Psychobiology and Behavioral Medicine
2016
In-Q-Tel
2016
Istituti di Ricovero e Cura a Carattere Scientifico
2015
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2015
Frailty denotes a multidimensional syndrome that gives rise to vulnerability stressors and leads an increase of the age-related decline different physiological systems cognitive abilities. Aging-related alterations immune system may compromise its competence culminating in chronic low-grade inflammation state. Thus, it has been proposed frailty is associated with concentration pro-inflammatory molecules lymphocyte subpopulations. To provide further support validity hypothesis, we conducted...
Polymorphisms in sex steroid receptors have been associated with transsexualism. However, published replication studies yielded inconsistent findings, possibly because of a limited sample size and/or the heterogeneity transsexual population respect to onset dysphoria and sexual orientation. We assessed role androgen receptor (AR), estrogen alpha (ERα) beta (ERβ), aromatase (CYP19A1) two large homogeneous male-to-female (MtF) female-to-male (FtM) populations.The association each polymorphism...
Abstract Superparamagnetic iron oxide nanoparticles (ION) have attracted great interest for use in several biomedical fields. In general, they are considered biocompatible, but little is known of their effects on the human nervous system. The main objective this work was to evaluate cytotoxicity two ION (magnetite), coated with silica and oleic acid, previously determining possible interference methodological procedures assure reliability results obtained. Human neuroblastoma SHSY5Y...
Although adverse health effects produced by lead (Pb) have long been recognized, studies regarding the immunotoxic of occupational exposure report conflicting results. In a previous study, alterations in some immunological parameters were noted 70 Pb-exposed workers. view these results, it was interest to extend this study comprising larger population and increasing number endpoints assessed. Accordingly, Pb assessed analyzing (1) percentages lymphocyte subsets (CD3+, CD4+, CD8+, CD19+,...
Mining activities may affect the health of miners and communities living near mining sites, these effects persist even when mine is abandoned. During processes various toxic wastes are produced released into surrounding environment, resulting in contamination air, drinking water, rivers, plants, soils. In a geochemical sampling campaign undertaken Panasqueira Mine area central Portugal, an anomalous distribution several metals arsenic (As) was identified environmental media. Several...
H2AX histone phosphorylation represents an early event in the cellular response against DNA double-strand breaks (DSBs), and plays a central role sensing repairing damage. Therefore, analysis of phosphorylated (γH2AX) may be possibly used as biomarker genotoxicity genomic instability with number applications human epidemiology. However, lack experimental standard leads to wide heterogeneity results obtained their interpretation, affecting reliability assay. To address most critical issues...
Titanium dioxide nanoparticles (TiO2 NPs) have a wide variety of applications in many consumer products, including as food additives, increasing the concern about possible hazards that TiO2 NPs may pose to human health. Although most previous studies focused on respiratory system, ingestion must also be considered an important exposure route. Furthermore, after inhalation or ingestion, can reach several organs, such liver, brain lungs. Taking this into consideration, present study focuses...