A5082926384- Chromatin Remodeling and Cancer
- Kruppel-like factors research
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- interferon and immune responses
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- Genomics, phytochemicals, and oxidative stress
- Cytokine Signaling Pathways and Interactions
- Nicotinic Acetylcholine Receptors Study
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Research on Leishmaniasis Studies
- Immune cells in cancer
- T-cell and Retrovirus Studies
- CAR-T cell therapy research
- Ion channel regulation and function
- RNA modifications and cancer
Texas Children's Hospital
2013-2025
Baylor College of Medicine
2016-2025
The University of Texas Health Science Center at Houston
2015
Children's Nutrition Research Center at Baylor College of Medicine
2011
Memorial Sloan Kettering Cancer Center
1997-2007
Consejo Nacional de Investigaciones Científicas y Técnicas
1992-1997
University of Buenos Aires
1993-1996
National Institutes of Health
1995-1996
Instituto de Química y Fisicoquímica Biológicas
1992-1996
Abstract Zika virus (ZIKV) is an emerging mosquito-borne ( Aedes genus) arbovirus of the Flaviviridae family. Although ZIKV has been predominately associated with a mild or asymptomatic dengue-like disease, its appearance in Americas accompanied by multi-fold increase reported incidence fetal microcephaly and brain malformations. The source mode vertical transmission from mother to fetus presumptively transplacental, although causal link explaining interval delay between maternal symptoms...
Abstract In acute myeloid leukemia (AML), SWI/SNF chromatin remodeling complexes sustain leukemic identity by driving high levels of MYC. Previous studies have implicated the hematopoietic transcription factor PU.1 (SPI1) as an important target inhibition, but is widely regarded to pioneer-like activity. As a result, many questions remained regarding interplay between and in AML well normal hematopoiesis. Here we found that binds most its targets SWI/SNF-independent manner recruits promote...
Acute lymphoblastic leukemia (ALL) is the most common hematological cancer in children. Although risk-adaptive therapy, CNS-directed chemotherapy, and supportive care have improved survival of ALL patients, disease relapse still leading cause cancer-related death Therefore, new drugs are needed as frontline treatments high-risk salvage agents relapsed ALL. In this study, we report that purified sulforaphane, a natural isothiocyanate found cruciferous vegetables, has anti-leukemic properties...
Bone marrow hematopoietic stem cells (HSCs) balance proliferation and differentiation by integrating complex transcriptional post-translational mechanisms regulated cell intrinsic extrinsic factors. We found that transcripts of G(0)/G(1) switch gene 2 (G0S2) are enriched in lineage(-) Sca-1(+) c-kit(+) (LSK) CD150(+) CD48(-) CD41(-) cells, a population highly for quiescent HSCs, whereas G0S2 expression is suppressed dividing LSK cells. Gain-of-function analyses using retroviral vectors bone...
Abstract In thymocyte ontogeny, Tcr-a genes rearrange after Tcr-b genes. TCRαβ transgenic (Tg) mice have no such delay, consequently expressing rearranged proteins early in the ontogeny. Such exhibit reduced thymic cellularity and accumulate mature, nonprecursor TCR+CD8−4− thymocytes, believed to be caused by premature Tg expression via unknown mechanism(s). Here, we show that of on thymocytes curtails expansion impairs CD8−4− → CD8+4+ transition. This effect is accomplished two distinct...
The development and survival of NK cells rely on a complex, spatiotemporal gene expression pattern regulated by specific transcription factors in tissue-specific microenvironments supported hematopoietic cells. Here, we show that somatic deletion the KLF4 gene, using inducible lineage-specific cre-transgenic mice, leads to significant reduction (NK1.1(+) TCR-β(-)) blood spleen but not BM, liver, or LNs. Functional immunophenotypic analyses revealed increased apoptosis CD27(+/-) CD11b(+)...
Abstract The differentiation of CD4+ T cells into different Th lineages is driven by cytokine milieu in the priming site and underlying transcriptional circuitry. Even though many positive regulators have been identified, it not clear how this process inhibited at level. In study, we report that E-twenty six (ETS) transcription factor E74-like 4 (ELF4) suppresses Th17 both vitro vivo. Culture naive Elf4−/− presence IL-6 TGF-β (or IL-6, IL-23, IL-1β) resulted increased numbers IL-17A–positive...
Abstract Previous studies provided evidence that MCA/129 fibrosarcomas and B16 melanomas grow 2- to 4-fold faster in acid sphingomyelinase (asmase)–deficient mice than asmase+/+ littermates are resistant single-dose irradiation due inability mount an apoptotic response tumor microvascular endothelium. However, others postulated the differences might be associated with a host antitumor immune is not expressed asmase−/− phenotypic deficiency immunity. The present demonstrate none of tumor–host...
Dietary influences may affect microbiome composition and host immune responses, thereby modulating propensity toward inflammatory bowel diseases (IBDs): Crohn disease (CD) ulcerative colitis (UC). n-6 fatty acids have been associated with UC in prospective studies. However, the critical developmental period when (n-6) consumption induce is not known. We examined effects of transiently increased during pediatric development on subsequent dextran-sulfate-sodium (DSS)-induced acute murine...
Abstract T cell receptor activation inhibits expression of the E74-like factor (ELF) 4 and Krüppel-like genes to release naive CD8+ cells from their quiescent state. In this study, we show that ELF4 controls ERK-mediated proliferative response by maintaining normal levels dual-specificity phosphatases 1 5 in cells. activated cells, mammalian target rapamycin pathway downstream ERK PI3K signaling. Our findings demonstrate could be used modulate transcriptional network involved cell-cycle regulation.