A5100678168- Fluorine in Organic Chemistry
- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Organic and Inorganic Chemical Reactions
- Carbohydrate Chemistry and Synthesis
- Multicomponent Synthesis of Heterocycles
- Inorganic Fluorides and Related Compounds
- Synthetic Organic Chemistry Methods
- Organophosphorus compounds synthesis
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Carbon dioxide utilization in catalysis
- Topic Modeling
- Catalytic Alkyne Reactions
- Microbial Natural Products and Biosynthesis
- Catalytic Cross-Coupling Reactions
- Quinazolinone synthesis and applications
- Crystallization and Solubility Studies
- Click Chemistry and Applications
Guangdong University of Technology
2024-2025
Shanghai Institute of Organic Chemistry
2015-2024
University of Chinese Academy of Sciences
2012-2024
China Telecom (China)
2024
China Telecom
2024
Shanghai Normal University
2022-2024
Chinese Academy of Sciences
2014-2023
Aerospace Information Research Institute
2022-2023
Hangzhou Normal University
2022
Beijing University of Chemical Technology
2021
The high mortality rate of immunocompromised patients with fungal infections and the limited availability highly efficacious safe agents demand development new antifungal therapeutics. To rapidly discover such agents, we developed a high-throughput synergy screening (HTSS) strategy for novel microbial natural products. Specifically, product library was screened hits that synergize effect low dosage ketoconazole (KTC) alone shows little detectable fungicidal activity. Through approximately...
The aldol reaction of methyl ketones and α,β-unsaturated trifluoromethyl occurred under mild conditions with the combination proline-derived N-sulfonylamide trifluoroacetic acid as catalyst to give corresponding unsaturated α-trifluoromethyl tertiary alcohols in high yields good enatioselectivities.
Direct trifluoromethylthiolation and trifluoromethylsulfinylation reactions by using sodium trifluoromethanesulfinate were promoted different phosphorus reagents to selectively occur under mild transition‐metal‐free conditions. In the presence of trichloride, readily underwent a reaction with indole its derivatives in N , ‐dimethylformamide (DMF) at room temperature give 3‐trifluoromethylthiolated products good yields. Trifluoromethylsulfinylation reactions, however, occurred C‐3 position...
A mild and efficient copper-catalyzed intramolecular carbotrifluoromethylation of alkynes has been achieved in the presence Togni reagent as trifluoromethylating reagent. The reaction tolerates a range substrates to give group trifluoromethylated heterocycles with high selectivities. plausible mechanism was proposed on basis experimental results.
Regio- and diastereoselective reduction of chiral trifluoromethyl alpha,beta-unsaturated N-tert-butanesulfinyl ketoimines 1 was achieved by choosing appropriate reducing agent either diastereomer the corresponding trifluoromethylated allylic amines obtained with good yield excellent diastereoselectivity (up to >99:1 dr).
The aza-Henry reaction of chiral fluoroalkyl α,β-unsaturated N-tert-butanesulfinyl ketoimines and nitromethane was achieved in the presence 0.2 equivalent anhydrous potassium carbonate to give corresponding adducts diastereoselectively high yields. Transformations which highlighted synthetic potential these were also performed.
Shape-controlled block copolymer (BCP) particles that respond to light stimulus have drawn great attention due their promising applications in smart materials, yet polymeric with light-triggered controllable sequential shape transformation (SST) are still rarely reported. By confined co-assembly of polystyrene-b-poly(2-vinylpyridine) (PS-b-P2VP) and azo-containing light-responsive additives within emulsions, herein, we fabricated BCP light-controlled SST behavior. Attributed the...
Abstract A mild and efficient transition metal‐free intramolecular oxyfluorination of alkenyl oximes is demonstrated. The reaction tolerates a range substrates to give series monofluoromethylated isoxazoline derivatives with good yields. possible pathways are proposed based on the results control experiments. magnified image
An efficient trifluoromethylthiolation‐based vicinal bifunctionalization of indoles with sodium trifluoromethanesulfinate in the presence phosphorus oxychloride were achieved to introduce a chlorine atom into 2‐position under transition‐metal‐free and mild conditions. The protocol could also extend other perfluoroalkanesulfinates or oxybromide. possible pathway was proposed based on experimental results.
Abstract A mild and efficient copper‐catalyzed oxytrifluoromethylation of allenes is demonstrated. The reaction tolerates a range substrates to give series trifluoromethylated derivatives in moderate good yields. Two possible pathways were proposed based on the results control experiments. magnified image
A solvent- and catalyst-free approach a one-pot process in water were reported for the synthesis of polyfluoroalkanesulfinyl or alkylsulfinyl 4-isoxazolines. These reactions are easy to perform demonstrate significant ecological advantages.
Abstract The trifluoromethylsulfinylation reaction of activated arenes with trifluoromethanesulfinyl chloride (CF 3 SOCl) in the presence Lewis acid was achieved under mild and solvent‐free conditions. A series aryl trifluoromethyl sulfoxides were obtained moderate to high yields. protocol could be extended perfluoroalkylsulfinylation arenes, as well indoles without additive.
A highly diastereoselective three-component inverse-electron-demand aza Diels-Alder reaction assisted by per(poly)fluoro-alkanesulfinamides is presented, providing a broad spectrum of functionalized piperidine derivatives with excellent endo/exo and facial diastereoselectivities. The electron-withdrawing perfluoroalkyl groups are crucial for the success this under mild conditions facilitate monitoring process stereoselectivities reaction. synthetic potential these cycloadducts also highlighted.
The copper-catalyzed highly regioselective reaction of internal alkynes with diaryliodonium salts was achieved for the first time. α-Arylketones were obtained in moderate to good yields from arylpropargylic alcohols or aryl alkyl under mild conditions. It found that two kinds substrates underwent different arylation–oxygenation pathways conditions based on deuterated experiments, controlling and spectroscopic analysis intermediates.
Copper-catalyzed O-arylation of enolates with diaryliodonium salts as arylating reagents was realized successfully. As important building blocks, β-aryloxy carbonyl compounds were obtained in up to 98% yield under mild conditions, and complete control Z-stereoselectivity achieved. The origin the selectivity also discussed.
A series of 1,4-diphenyl-1,2,3-triazole-incorporated amide derivatives have been designed and prepared. X-ray crystallographic (1D 2D) (1)H NMR studies reveal that these compounds fold into stable U-shaped conformations driven by three-center intramolecular C-H···O hydrogen-bonding formed between the triazole C-5 H atom two ether O atoms. Such folded structures make this 1,4-diphenyl-1,2,3-triazole skeleton a good candidate to be used as β-turn mimic. To prove this, formation β-hairpin...
Abstract The Reformatsky reaction of bromodifluoromethyl ketones and imines took place readily in the presence Zn/CuCl at room temperature to afford β‐amino α,α‐difluoro good yields. Using ( S )‐ tert ‐butanesulfinyl as a chiral auxiliary, asymmetric was also achieved found proceed with excellent diastereoselectivities. A plausible model is proposed account for high stereoselectivity reaction.
Copper-catalyzed stereoselective oxytrifluoromethylation of terminal propargyl amides was investigated for the construction oxazolines under mild conditions.