Despite advances in clinical management, cardiovascular disease remains the leading cause of death America. While cardiomyocytes retain limited plasticity following maturation, heart is grossly unable to recover from structural damage. Mesenchymal stem cell (MSC) therapy, through its promise repair and regeneration cardiac tissue, represents an exciting avenue treatment for a range diseases. MSCs are relatively immunoprivileged, lacking both major histocompatibility II T-cell co-stimulatory...

A BSTRACT Exogenous lipoid pneumonia (ELP) is a rarely reported entity caused by aspirating or inhaling fat oil-containing substances. Clinically, patients present with subacute to chronic-onset non-specific symptoms such as cough, fever, breathlessness, and general malaise. In addition, lobar multifocal interstitial parenchymal infiltrates on chest imaging can mimic any other infectious etiology. Diagnosis of often missed delayed in many cases requires high index clinical suspicion. We...

Among thyroid malignancies, papillary carcinoma (PTC) is the most common, with classical variant being common subtype. Some histological variants have aggressive behavior, advanced presentation stages, poor clinical outcomes, and may require additional therapy. Due to overlapping cytologic features heterogeneity of lesions, PTC classification not adhered in conventional reporting practice. This study aimed classify cytology cases into a particular cytological by applying an algorithmic...

Introduction: Adrenal myelolipoma (AML) is a benign tumor that histologically comprises variable admixture of hematopoietic cells and adipose tissue. Most these tumors are nonfunctional asymptomatic but can sometimes pose challenges in differential diagnosis. We present cohort 115 cases AML, emphasizing their clinicoradiological pathological features, associated adrenal lesions, variables inferring the complications. Materials Methods: All proven AML who underwent adrenalectomy from 2003 to...

Limited data exist on whether early colonoscopy for lower gastrointestinal bleeding (LGIB) alters 30-day mortality, performance of endoscopic intervention, or need blood transfusion. Our primary objective was to determine in LGIB is associated with decreased mortality using a large hospital administrative database.Patients hospitalized between January 2008 and September 2015 were identified validated, machine learning algorithm identifying patients LGIB. "Early" occurred by day 2 admission...

Goals: To evaluate whether resumption of warfarin after hospitalization for lower gastrointestinal bleeding (LGIB) is associated with improved 90-day and 6-month survival. Background: LGIB a common complication patients on warfarin. There limited data to guide clinicians the optimal management following LGIB. Study: We identified hospitalized while using validated, machine-learning algorithm. Patients were classified as those who had resumed at discharge did not. Univariate multivariate Cox...

Abstract Background Lower gastrointestinal bleeding (LGIB) is a common complication for patients with coronary artery disease (CAD) due to the use of antithrombotic medications. Limited data exist describing which are at increased risk mortality. Aim This study aims (i) determine whether on dual antiplatelet therapy (DAPT) or triple higher 90‐day and 6‐month mortality compared aspirin alone (ii) evaluate factors in CAD antithrombotics hospitalized LGIB. Methods We conducted retrospective...

To investigate the current management of gastric antral webs (GAWs) among adults and identify optimal endoscopic and/or surgical for these patients.We reviewed our endoscopy database seeking to patients in whom a GAW was visualized 24640 esophagogastroduodenoscopies (EGD) over seven-year period (2006-2013) at single tertiary care center. The diagnosis suspected during EGD if aperture size antrum did not vary with peristalsis or "double bulb" sign present on upper gastrointestinal series....

Abstract Introduction Protein C (PrC), a physiological anticoagulant, regulates inflammation and cell death has known predictive/therapeutic roles in sepsis. Accumulating evidences suggest plasma hypercoagulability results progression of fibrosis formation microclots causing end‐organ dysfunction. We investigated possible association between natural anticoagulants—PrC, protein S (PrS) antithrombin III ( AT )—and clinical outcomes cirrhotics. Methods Functional PrC, PrS were analysed 515...

A small bowel source is suspected when evaluation of overt gastrointestinal (GI) bleeding with upper and lower endoscopy negative. Video capsule (VCE) the recommended next diagnostic test for sources. However, clinical or endoscopic predictive factors in setting an presentation are unknown. We aimed to define positive VCE among individuals presenting a source.We included consecutive inpatient performed between September 1, 2012 2015 melena hematochezia at two tertiary centers. All patients...

<br><b>Introduction:</b> Early and accurate diagnosis is paramount for improving the therapeutic efficacy of pancreatic cancers. Endoscopic ultrasonography–fine needle aspiration (EUS-FNA) cytology has come up with advantage an early This study was conducted to analyze spectrum lesions cytology, appraise diagnostic accuracy EUS-FNA solid cystic lesions. <b>Materials Methods:</b> retrospective includes 288 EUS-guided FNA cases. Clinical data, laboratory tests, cytopathology, histopathology,...

We read with interest the case series by Nagral A et al.1Nagral A. Adhyaru K. Rudra O.S. Gharat Bhandare S. Herbal immune booster-induced liver injury in COVID-19 pandemic - a series.J Clin Exp Hepatol. 2021 Jul 2; https://doi.org/10.1016/j.jceh.2021.06.021Abstract Full Text PDF Scopus (34) Google Scholar The authors highlight vexing predicament brought to fore amidst frequent usage of "immune boosters" during pandemic. In this context, we share our experience and delve into certain key...

Background: The use of safe and effective contraception is the need hour in India, with one world’s largest fastest growing population. Assessing acceptance compliance women for temporary DMPA. Acceptance shall be compared between different reproductive age group, parity among lactating/non lactating female. Methods: In this study, 100 have been taken, those were appropriate within inclusion criteria period year. Injection DMPA 150 mg injected intramuscularly every 3 months used...

Inflammatory pseudotumor (IPT) of the liver is a rare, tumor-like lesion that considered to be biologically benign but often mimics malignancy.The aim study was construe clinicopathological features, imaging findings, differential diagnosis, management, and follow-up IPT involving liver.It retrospective study.Cases included were IPT, diagnosed on histopathology, at our center from June 2009 December 2016. Details studied clinical presentation, studies, laboratory investigations, pathological...

Bronchial carcinoid is the most common primary malignant lung tumor in children; however, it remains a very rare diagnosis due to overall low incidence of childhood malignancies. We report case 17-year-old girl with respiratory symptoms who was initially misdiagnosed as COVID pneumonia. She later detected have right mainstem bronchial which managed successfully by multi-disciplinary team.

Abstract Aims To evaluate the effect of donor liver resident mesenchymal cells, M2 macrophages on graft outcome after living transplantation. Materials and methods Seventy biopsies were included in study. Outcomes at day 3, 7, 30, 180 postliver transplantation assessed. Mesenchymal stem cells evaluated. Results Mean age recipients was 40.9 ± 13.6 years. Sex mismatched transplants 44 (M→F = 9; F→M 35). On area under receiver operative curve analysis, biopsy ( DB ) nestin ≥3 CD 163 ≥ 32/200x...

Introduction: Medullary thyroid carcinoma (MTC) is a malignant tumor of gland showing parafollicular or C-cell differentiation. Aims and objectives:The current study was undertaken to evaluate safety ultrasound-guided fine-needle aspiration cytology (FNAC) assess cytomorphological features MTC in FNA specimens from 28 patients. Materials methods:The performed by retrospectively reviewing the clinical pathological records cases managed at our institute. Results:The patients included 18 males...