A5033043178- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Cerebral Venous Sinus Thrombosis
- Neurological diseases and metabolism
- Botulinum Toxin and Related Neurological Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Glaucoma and retinal disorders
- Inflammation biomarkers and pathways
- Amyotrophic Lateral Sclerosis Research
- Cerebrovascular and genetic disorders
- Genomics and Rare Diseases
- Long-Term Effects of COVID-19
- Autoimmune Neurological Disorders and Treatments
- Olfactory and Sensory Function Studies
- Dysphagia Assessment and Management
- Epilepsy research and treatment
- Cellular transport and secretion
- Trigeminal Neuralgia and Treatments
- Lysosomal Storage Disorders Research
- Genetics and Neurodevelopmental Disorders
Istanbul University
2016-2025
Maastricht University
2024
Istanbul Medipol University
2024
McGill University
2024
Montreal Neurological Institute and Hospital
2024
Fatih University
2024
Eskişehir Osmangazi University
2022
Parkinson's disease is a progressive neurodegenerative disorder with multifactorial causes, among which genetic risk factors play part. The RAB GTPases are regulators and substrates of LRRK2, variants in the LRRK2 gene important for disease. We aimed to explore variability within cases familial
Abstract INTRODUCTION Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish cohesive clinical phenotype. METHODS Retrospective data from 18 centers across 12 countries yielded 360 FTD patients predominant RATL atrophy through initial neuroimaging assessments. RESULTS Common symptoms included mental rigidity/preoccupations (78%),...
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder. Mendelian forms have revealed multiple genes, with notable emphasis on membrane trafficking; RAB GTPases play an important role in PD as subset are both regulators and substrates of LRRK2 kinase. To explore the PD, we undertook comprehensive examination their genetic variability familial PD.Methods: Affected probands from 130 multi-incident families underwent whole-exome sequencing genotyping, Potential...
Objective: Neuroinflammation is involved in the pathology of Alzheimer's disease (AD).Peripheral levels various inflammatory cytokines are altered during AD pathogenesis.This study aimed to examine role peripheral inflammation pathogenesis by measuring serum and gene expression specific patients.Therefore, we analyzed interleukin-6 (IL-6) transforming growth factor-beta 1 (TGF-β1) mRNA expressions IL-6 tumor necrosis factor-alpha (TNF-α) blood mononuclear cells patients controls.Materials...
ABSTRACT Background Understanding real‐world experiences is crucial in determining the potential gaps patient‐centered healthcare dystonia. We explored challenges of people with dystonia (PwD) at stages diagnosis and botulinum neurotoxin (BoNT) treatment. Methods A multicenter survey was conducted face‐to‐face across seven university hospitals Turkey. PwD receiving BoNT treatment for least 6 months were invited. Data on demographics, diagnostic journeys, collected analyzed using descriptive...
Background The data that we gathered from a protein-protein interaction (PPI) prediction tool, FpClass, and limited number of studies indicated the chaperones HSP90AA1, HSPA4, STUB1/CHIP might interact with amyloid-β (Aβ) and/or tau could subsequently be co-released into cerebrospinal fluid (CSF). Therefore, investigated CSF levels in Alzheimer's disease (AD), Non-AD mild cognitive impairment (Non-AD MCI), frontotemporal dementia (FTD) cases. Methods STUB/CHIP, core AD biomarkers were...
Summary Background Parkinson’s disease (PD) is a progressive neurodegenerative disorder. Mendelian forms have revealed multiple genes, with notable emphasis on membrane trafficking; RAB GTPases play an important role in PD as subset are both regulators and substrates of LRRK2 protein kinase. To explore the PD, we undertook comprehensive examination their genetic variability familial PD. Methods Affected probands from 130 multi-incident families underwent whole-exome sequencing genotyping,...
Background Although specific role players are currently unknown, contribution of inflammatory mediators has been suggested in the pathophysiology idiopathic intracranial hypertension (IIH), which is a disease more prevalent obese female individuals childbearing age. We aimed to investigate levels adipokines and cytokines demonstrate possible markers for inflammation that participate IIH their association with clinical features IIH. Methods patients, diagnosed according revised criteria,...
Parkinson's disease (PD) is a progressive neurodegenerative characterized by motor and early non-motor symptoms. The habenula implicated in the pathophysiology of depression. This study investigates habenular volume PD patients without clinical depression to show changes unrelated used high-resolution 7 Tesla MRI data from TRACK-PD involving 104 44 healthy controls (HCs). was manually segmented, volumes were measured, considering demographic scores via Beck Depression Inventory (BDI). No...
Background: Right temporal variant frontotemporal dementia (rtvFTD) has been generally considered as a right sided of semantic primary progressive aphasia (svPPA), which is genetically sporadic disorder. Recently, we have shown that rtvFTD unique clinical syndrome compared to svPPA and behavioral dementia. Objective: We challenge the assumption sporadic, non-familial FTD by identifying potential autosomal dominant inheritance related genes in rtvFTD. Methods: collected all subjects with...
Dissecting biological pathways highlighted by Mendelian gene discovery has provided critical insights into the pathogenesis of Parkinson's disease (PD) and neurodegeneration. This approach ultimately catalyzes identification potential biomarkers therapeutic targets. Here, we identify
Background Although migraine usually begins in the early decades of life, late onset with aura is occasionally observed and can occur without headache, causing confusion differential diagnosis. Case report A 72-year-old man presented recurrent episodes visual lasting for 20 minutes. These had started at 57 years age were only once accompanied by a severe headache. Magnetic resonance imaging revealed changes periventricular white matter, left occipital haemorrhage subcortical haemosiderin...
Background: Sleep disorders and disturbances are generally underestimated in patients with epilepsy. The aim of this study is to determine the frequency sleep comorbidity people epilepsy without any complaints about their relation sudden unexplained death (SUDEP) risk. Methods: presence were assessed 4 questionnaires 139 Subjective features evaluated Pittsburgh Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Berlin Questionnaire for apnea, restless legs syndrome International Restless...
Sports activities provide social interaction for humans. Commitment to a given team is salient feature of being sports fan and becomes prominent part self-identification fanatics. Emotion, subjective hedonic experience, non-romantic love are related behaviors. Few studies have evaluated the neural basis fanaticism.Thirty men, including 16 football fanatics 14 non-fanatics, with mean age 27.4 ± 6.4 years (range, 20-48 years) were enrolled. Subjects underwent functional MRI while watching set...