A5006629075- Metabolism, Diabetes, and Cancer
- Research on Leishmaniasis Studies
- Adipose Tissue and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Trypanosoma species research and implications
- Cell Adhesion Molecules Research
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Pancreatic function and diabetes
- Muscle Physiology and Disorders
- Sirtuins and Resveratrol in Medicine
- Cellular Mechanics and Interactions
- High-Energy Particle Collisions Research
- Microtubule and mitosis dynamics
- Biochemical and Molecular Research
- PI3K/AKT/mTOR signaling in cancer
- Particle physics theoretical and experimental studies
- Cancer therapeutics and mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Animal Genetics and Reproduction
- Synthesis and biological activity
- Lysosomal Storage Disorders Research
- Cellular transport and secretion
- Melanoma and MAPK Pathways
- Ubiquitin and proteasome pathways
Indian Institute of Technology Delhi
2015-2025
Nil Ratan Sircar Medical College and Hospital
2013
Medical College and Hospital, Kolkata
2013
National Institute of Pharmaceutical Education and Research
2002-2012
National Institute of Pharmaceutical Education and Research
2002-2009
CASI Pharmaceuticals (United States)
2003
National Institute of Pharmaceutical Education and Research
2002
GTx (United States)
2000
National Institute of Immunology
1995
Weatherford College
1995
ABSTRACT Miltefosine causes leishmanial death, but the possible mechanism(s) of action is not known. The mode miltefosine was investigated in vitro Leishmania donovani promastigotes as well extra- and intracellular amastigotes. Here, we demonstrate that induces apoptosis-like death L. based on observed phenomena such nuclear DNA condensation, fragmentation with accompanying ladder formation, situ labeling fragments by terminal deoxyribonucleotidyltransferase-mediated dUTP-biotin nick end...
Metformin lowers blood glucose levels in type 2 diabetic patients. To evaluate the insulin sensitizing action of metformin on skeletal muscle cells, we have used C2C12 cells differentiated chronic presence or absence insulin. was added during last 24 h differentiation myotubes. Insulin‐stimulated tyrosine phosphorylation receptor (IR) and substrate‐1 (IRS‐1) determined. Chronic treatment resulted 60 40% reduction insulin‐stimulated IR IRS‐1, respectively. Treatment with able to increase...
Lipid and protein tyrosine phosphatase, phosphatase tension homologue (PTEN), is a widely known negative regulator of insulin/phosphoinositide 3-kinase signaling. Down-regulation PTEN thus documented to ameliorate insulin resistance in peripheral tissues such as skeletal muscle adipose. However, not much about its exact role neuronal signaling resistance. Moreover, alterations systems have led discovery several unexpected outcomes, including the neurodegenerative disorder Alzheimer's disease...
Prostate specific antigen (PSA) is a kallikrein family member with serine protease activity commonly used as diagnostic marker for prostate cancer. We recently described anti-angiogenic properties of PSA [Fortier et al.: JNCI 91:1635-1640].Two forms were cloned and expressed in Pichia pastoris: one, an intact N-terminus IVGGVS em leader; the second, N-1 variant. The recombinant proteins tested vitro vivo.The rate substrate hydrolysis by was similar to that isolated purified from human...
We examine the effects of soft gluons on Higgs boson production in association with a $Z$ at Large Hadron Collider (LHC). Utilizing universal cusp anomalous dimensions and splitting kernels, we analyze gluon fusion $ZH$ process, focusing total cross-section as well invariant mass distribution next-to-leading logarithmic level. Additionally, estimate next-to-soft this subprocess to same level accuracy. A detailed phenomenological analysis is performed for $13.6$ TeV LHC. Finally, combining...
Calreticulin (CALR) is an endoplasmic reticulum chaperone. Frameshift mutations in CALR were discovered patients with myeloproliferative neoplasm showing increased platelet counts. The frameshift was observed the last exon of CALR, leading to a novel C-terminal tail. categorised into Type I and II depending upon extent retention WT sequences. Clinically, induced myelofibrosis, while associated early onset disease. Both ligand-independent activation thrombopoietin receptor (TpoR) consequently...
ABSTRACT A high molecular mass dynein ATPase polypeptide and a 18-20 kDa light chain of Ciona sperm flagella are phosphorylated during in vivo activation motility or vitro by incubation with cyclic AMP. similar level phosphorylation these proteins is obtained washed, demembranated spermatozoa catalytic subunit AMP-dependent protein kinase, under conditions where there no until supernatant component added. Therefore, polypeptides not sufficient for motility. Activation AMP can be completely...
Peroxisome proliferator‐activated receptor‐ γ (PPAR‐ ) expression is very low in skeletal muscle cells, which one of the most important target tissues for insulin and plays a predominant role glucose homeostasis. It has recently been shown that muscle‐specific PPAR‐ deletion mouse causes resistance. However, it likely observed effects might be due to secondary interaction whole animal. The aim study was explore sensitivity. We stably transfected C2C12 cells with plasmids containing sense or...
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, has recently been implicated in the regulation of insulin resistance vitro. However, its vivo validation not attempted due to lethality FAK knockout. Hence, ascertain role development vivo, we have down-regulated expression by delivering FAK-specific small interfering RNA (siRNA) mice using hydrodynamic tail vein injection. Here, show for first time that silencing (57 +/- 0.05% muscle and 80 0.08% liver) exacerbates signalling...