A5012135189- vaccines and immunoinformatics approaches
- Hepatitis C virus research
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Click Chemistry and Applications
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- DNA and Nucleic Acid Chemistry
- Viral Infections and Outbreaks Research
Université Mohammed VI Polytechnique
2022-2024
Cadi Ayyad University
2024
Ebola virus disease is a deadly pathogenic with fatality rate of 25–90 % as recorded in previous outbreaks. The Virus glycoprotein (EBOV-GP) plays crucial role the entry viruses into human cells, making it an interesting target for therapeutic discovery. Therefore, inhibiting this protein can directly limit replication and progression at early stage infection. present study focuses on design novel potent EBOV-GP inhibitors using multiple computational techniques. In context, two QSAR models...
Hepatitis C virus (HCV) is a serious disease that threatens human health. Despite consistent efforts to inhibit the virus, it has infected more than 58 million people, with 300,000 deaths per year. The HCV nonstructural protein NS5A plays critical role in viral life cycle, as major contributor replication and assembly processes. Therefore, its importance evident all currently approved combination treatments. present study identifies new potential compounds for possible medical use against...
Hepatitis C virus (HCV) presents a significant global health issue due to its widespread prevalence and the absence of reliable vaccine for prevention. While progress has been achieved in therapeutic interventions since disease was first identified, resurgence underscores need innovative strategies combat it. The nonstructural protein NS5A is crucial life cycle HCV, serving as factor both viral replication assembly processes. This significance highlighted by inclusion all existing approved...