A5009488592- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Diabetes Management and Research
- Tuberculosis Research and Epidemiology
- Genomics and Rare Diseases
- Biomedical and Engineering Education
- Pituitary Gland Disorders and Treatments
- Breast Cancer Treatment Studies
- Pneumonia and Respiratory Infections
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Diet and metabolism studies
- Family Support in Illness
- Pneumocystis jirovecii pneumonia detection and treatment
- Ethics in Clinical Research
- Artificial Intelligence in Healthcare
- 3D Printing in Biomedical Research
- Pancreatic function and diabetes
- Patient-Provider Communication in Healthcare
- Pharmaceutical studies and practices
- Cardiac electrophysiology and arrhythmias
- Breast Lesions and Carcinomas
- Health Systems, Economic Evaluations, Quality of Life
- Health Policy Implementation Science
- Cancer and Skin Lesions
Virginia Commonwealth University
2023-2024
Philadelphia College of Osteopathic Medicine
2022
University of Pittsburgh
2017-2020
California Institute of Behavioral Neurosciences and Psychology (United States)
2020
University of Iowa
2013-2020
Oncology Nursing Society
2020
University of Massachusetts Amherst
2020
Koç University
2020
Istanbul University
2020
Smt. N.H.L. Municipal Medical College
2020
Because hematopoietic stem cells are rich in aldehyde dehydrogenase (ALDH) activity, we developed a fluorescent substrate for ALDH, termed BODIPY aminoacetaldehyde (BAAA), and tested its potential isolating primitive human cells. A population of with low orthogonal light scattering bright fluorescence intensity (SSC lo ALDH br cells) could be readily fractionated from umbilical cord blood costained BAAA the multidrug-resistance inhibitor verapamil. The SSC was depleted lineage-committed...
Postprandial hyperglycemia drives insulin resistance and inflammation, leading to metabolic dysfunction-associated fatty liver disease (MAFLD). Prediction of postprandial glycemic responses by digital twin (DT) technology can fashion a personalized nutrition, activity, sleep treat type 2 diabetes (T2D) MAFLD. This study examines the effects DT-enabled on status, surrogate markers MAFLD, magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF) in patients with T2D.In an...
The potential for genomic incidental findings is increasing with the use of genome-based testing. At same time approaches to clinical decision making are shifting shared decision-making models involving both healthcare community and public. public's voice has been nearly absent in discussions on managing findings. We conducted nine focus groups interviews (n = 63) a broad cross-section lay public elucidate viewpoints that could occur as result testing research situations. Data were analyzed...
Type 2 Diabetes (T2D) is a complex condition marked by insulin resistance and beta-cell dysfunction. Traditional dietary interventions, such as low-calorie or low-carbohydrate diets, typically overlook individual variability in postprandial glycemic responses (PPGRs), which can lead to suboptimal management of the disease. Recent advancements suggest that personalized nutrition, tailored metabolic profiles, may enhance effectiveness T2D management.
Background The rise of online recruitment and data collection in qualitative research has led to an increase imposter participants. Imposter participants are dishonest individuals who fake or exaggerate their identities participate studies, usually for financial gain. This issue poses significant challenges integrity, ethics, resource allocation. Aim To raise awareness address the ethical, diversity inclusivity considerations related participation research. Method Our cross-organisational...
Abstract Background Type 2 diabetes reversal has been viewed in the literature primarily as a dichotomous event (reversed or not reversed), even though this viewpoint may be optimal for clinicians patients. This cohort study’s objectives were to define stages of type and measure changes before after 90 days digital twin-enabled precision nutrition therapy. Methods study defines seven reversal. The is retrospective pre/post comparison stage, hemoglobin A1c (HbA1c), weight, body mass index...
Abstract This retrospective observational study, building on prior research that demonstrated the efficacy of Digital Twin (DT) Precision Treatment Program over shorter follow-up periods, aimed to examine glycemic control and reduced anti-diabetic medication use after one-year in a DT commercial program. T2D patients enrolled had adequate hepatic renal function no recent cardiovascular events. intervention powered by artificial intelligence utilizes precision nutrition, activity, sleep,...
Next generation sequencing offers benefit of improved health through knowledge, but comes with challenges, such as inevitable incidental findings (IFs). The applicability recommended criteria for disclosure individual results when applied to IFs is not well known. purpose this study was examine how medical genetic specialists, genomic researchers, and Institutional Review Board (IRB) chairs perceive the importance genetic/genomic IFs. We conducted telephone interviews specialists (genetic...
Peru reports among the highest multidrug-resistant tuberculosis (MDR-TB) rates in Americas, with a growing proportion previously untreated (TB) cases. The identification of clusters primary MDR-TB compared drug-susceptible TB (DS-TB) could help prioritize interventions.To examine clustering case residences and their proximity to high-risk locations San Juan de Lurigancho District, Lima, Peru.Enrolled DS-TB cases were interviewed residence was recorded using handheld Global Positioning System...
The purpose of this study was to identify characteristics family relationships associated with communication genetic risk and testing behaviors among at-risk relatives in families an inherited cardiac condition. Data were collected from 53 patients parents children condition through interviews, pedigrees, surveys. Associations examined relationship whether informed about their tested for disease. Of 1,178 relatives, 52.5% 52.1% those tested. Emotional closeness, quality, frequency had...
Background When a woman is diagnosed with hereditary breast or ovarian cancer, family members may be at high risk of cancers associated BRCA1/2 gene mutation and benefit from disclosure the genetic test result. This duty informing relatives distressing, not properly informed. Objective To qualitatively describe cancer patients’ experiences communicating to their relatives. Methods Probands mutations were recruited an oncology institute in Istanbul, Turkey, interviewed by telephone....
SUMMARY We compared the cost-effectiveness (CE) of an active case-finding (ACF) programme for household contacts tuberculosis (TB) cases enrolled in first-line treatment to routine passive (PCF) within established national TB Peru. Decision analysis was used model detection through: (1) self-report symptomatic evaluation (PCF), (2) a provider-initiated ACF programme, (3) addition Xpert MTB/RIF diagnostic test single sputum sample from contacts, and (4) all strategies combined. CE calculated...
Using the familial risk perception (FRP) model as a framework, we elicited causal and inheritance explanations for type 2 diabetes (T2D) from people who do not have T2D but family history it. We identified four composite mental models cause of T2D: (a) purely genetic; (b) behavioral/environmental; (c) direct multifactorial, in which factors interact over time directly lead to T2D; (d) indirect precursor health condition (such obesity or metabolic syndrome) that leads T2D. Interestingly,...
The genetic risk communication from proband to relatives varies family family, and patients often need support with the of test results making decisions manage hereditary cancer risks.The aim this study was characterize BRCA1 or BRCA2 (BRCA1/2) first-degree (FDRs) using a social network framework.We characterized nonnetwork factors explore their association which FDRs were told about whether not underwent testing. Ninety-two female probands breast ovarian who have confirmed BRCA1/2 mutations...
Digital twin (DT)-guided lifestyle changes induce type 2 diabetes (T2D) remission but effects on hypertension (HTN) in this population are unknown.