A5011026468- Neuroscience and Neural Engineering
- Advanced Sensor and Energy Harvesting Materials
- EEG and Brain-Computer Interfaces
- Photoreceptor and optogenetics research
- Luminescence and Fluorescent Materials
- Tactile and Sensory Interactions
- Nanoplatforms for cancer theranostics
- Molecular Communication and Nanonetworks
- Ultrasound and Hyperthermia Applications
- Tissue Engineering and Regenerative Medicine
- Vagus Nerve Stimulation Research
- Electrospun Nanofibers in Biomedical Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Chemistry and Complexes
- Connexins and lens biology
- Gaze Tracking and Assistive Technology
- Muscle activation and electromyography studies
- Advanced Memory and Neural Computing
- Covalent Organic Framework Applications
The University of Texas at Austin
2022-2025
Optogenetics has revolutionized neuroscience understanding by allowing spatiotemporal control over cell-type specific neurons in neural circuits. However, the sluggish development of noninvasive photon delivery brain limited clinical application optogenetics. Focused ultrasound (FUS)-derived mechanoluminescence emerged as a promising tool for situ emission, but there is not yet biocompatible liquid-phase system To achieve optogenetics with high temporal resolution and desirable...
High-quality and continuous electroencephalogram (EEG) monitoring is desirable for sleep research, monitoring, the evaluation treatment of disorders. Existing EEG technologies suffer from fragile connections, long-term stability, complex preparation electrodes under real-life conditions. Here, we report an injectable spontaneously cross-linked hydrogel electrode applications. Specifically, our have a low impedance on hairy scalp regions 17.53 kΩ more than 8 h recording, high adhesiveness...
Remote and genetically targeted neuromodulation in the deep brain is important for understanding treatment of neurological diseases. Ultrasound-triggered mechanoluminescent technology offers a promising approach achieving remote modulation. However, its application has thus far been limited to shallow depths due challenges related low sonochemical reaction efficiency restricted photon yields. Here we report cascaded nanotransducer achieve efficient light emission upon ultrasound stimulation....
Cell-type-specific activation of parvalbumin (PV)-expressing neurons in the external globus pallidus (GPe) through optogenetics has shown promise facilitating long-lasting movement dysfunction recovery mice with Parkinson's disease. However, its translational potential is hindered by adverse effects stemming from invasive implantation optical fibers into brain. In this study, we have developed a non-invasive approach, utilizing focused ultrasound-triggered mechanoluminescent nanotransducers...
Abstract Electroencephalography (EEG) is a cornerstone in both neuroscience research and clinical diagnostics. However, conventional EEG monitoring faces hardware limitations, particularly its adaptability stability. Headsets either require complicated wiring or do not have enough stretchability wearability to comply with the diverse head anthropometry hair conditions of user population. Additionally, there an inherent tradeoff between wet dry electrodes capturing high-fidelity signals from...
The precise control of mechanochemical activation within deep tissues via non-invasive ultrasound holds profound implications for advancing our understanding fundamental biomedical sciences and revolutionizing disease treatments. However, a theory-guided mechanoresponsive materials system with well-defined has yet to be explored. Here we present the concept using porous hydrogen-bonded organic frameworks (HOFs) as toolkits focused programmably triggered drug specific cellular events in...
Abstract Transcranial focused ultrasound has become a promising non-invasive approach for neuromodulation applications, particularly neurodegenerative diseases and psychiatric illnesses. However, its implementation in wearable thus far been limited due to the devices’ large size, which needs external supporting systems process. Furthermore, need gel acoustic coupling between device skin limits viability long-term use, inherent susceptibility dehydration lack of adhesiveness form stable...