A5100665708- Bone Metabolism and Diseases
- Bone health and treatments
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Retinal Development and Disorders
- Folate and B Vitamins Research
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Osteomyelitis and Bone Disorders Research
- Circular RNAs in diseases
- Antioxidant Activity and Oxidative Stress
- Inflammatory mediators and NSAID effects
- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Cell Adhesion Molecules Research
- Sulfur Compounds in Biology
- Advanced Glycation End Products research
- Chronic Kidney Disease and Diabetes
Chinese University of Hong Kong
2020-2024
Peking University
2018
Peking University First Hospital
2018
Case Western Reserve University
2013
Cuscuta chinensis Lam. (Convolvulaceae) is an important herbal medicine widely used to improve sexual function, treat osteoporosis, and prevent aging, has been reported exhibit anti-osteoporotic effects in vitro. However, the activity of on glucocorticoid-induced osteoporosis still remains unclear. The present study aimed assess protective effect underlying mechanism action extract (CCE) against vivo. Sprague-Dawley rats were randomly divided into four groups as follows: control group, 2...
Recently, aberrantly high levels of D-ribose have been discovered in type II diabetic patients. glycates proteins more rapidly than D-glucose, resulting the production advanced glycation end products (AGEs). Accumulations these can be found impaired renal function, but mechanisms are poorly understood. The present study tested whether induces dysfunction via RAGE-dependent NF-κB signaling pathway. In vivo, administration was to lower blood glucose and regulate insulin tolerance. Compared...
Lowered muscle regenerative capacity in the elderly greatly contributes to development of multiple diseases. The specific roles long noncoding RNAs (lncRNAs) during aging remain unknown. Here, we identify an elevated lncRNA (lncRNA-3), association with reduced MyoD expression and suppressed capacity, skeletal aged mice. LncRNA-3 could interact both
Mutations in the STRA6 gene are associated with fatal Human Micro‐ophthalmic Syndrome 9. We generated a mouse model to elucidate biochemical basis of this congenital disease. These mice failed transport vitamin A across blood‐retina and ‐ brain barrier developed blindness, anomalies hydrocephalus. Restriction embryonic supply extended malformations extra‐neuronal tissues, whereas pharmacological doses mitigated STRA6‐deficient offspring. Our study established critical role for retinoid...