A5102967358- Bone Metabolism and Diseases
- S100 Proteins and Annexins
- Bone health and treatments
- Diabetic Foot Ulcer Assessment and Management
- Bone Tissue Engineering Materials
- Bone and Joint Diseases
- Therapeutic Uses of Natural Elements
- Foot and Ankle Surgery
- Clay minerals and soil interactions
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Lower Extremity Biomechanics and Pathologies
- Pressure Ulcer Prevention and Management
- Nanoparticle-Based Drug Delivery
- Peripheral Artery Disease Management
- Hydrogels: synthesis, properties, applications
- Luminescence and Fluorescent Materials
- Wound Healing and Treatments
- Tendon Structure and Treatment
- Biochemical and Structural Characterization
- Medicinal Plants and Neuroprotection
- Hydrogen's biological and therapeutic effects
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Hemostasis and retained surgical items
Guangdong Provincial People's Hospital
2021-2024
Guangdong Work Injury Rehabilitation Hospital
2024
Jinan University
2024
First Affiliated Hospital of Jinan University
2024
Health First
2022
To investigate the effect of transverse tibial bone transport on treatment Wagner Stage 4 diabetic foot.From January 2017 to October 2019, a total 19 patients with foot ulcers were recruited. All treated transport. A detailed follow-up was carried out at 1 week, month, 3 months, 6 and year after surgery. The wound healing rate limb salvage surgery evaluated. Preoperative 3-month postoperative digital subtraction angiography (DSA) obtained. level vascular endothelial growth factor (VEGF),...
Impaired mitochondrial autophagy and ferroptosis in Human Immortalized Epidermal Cells (HaCats), caused by oxidative stress, are significant obstacles to diabetic wound healing. However, research on the mechanistic level of skin repair through improvement function inhibition iron-induced cell death natural-based hydrogel materials is still lacking. In this study, we engineered pH glucose-responsive Hst1@CBTC hydrogels leveraging dynamic borate bonding, exhibiting an impressive peptide...
Viola betonicifolia is a rich source of numerous secondary metabolites, such as alkaloids, flavonoids, tannins, phenolic compounds, saponins, triterpenoids, and so on, that are biologically active towards different potential biomedical applications. To broaden the use in realm bionanotechnology, we investigated plant's ability to synthesize gold nanoparticles (Au NPs) green efficient manner for very first time.The (VB-Au were synthesized using leaves extract betonicifolia, which metabolites...
Hydrogel serve as bone tissue engineering have lately received great attention for their good biocompatibility and structures similar to natural extracellular matrices. However, a single component polymer hydrogel is generally detrimental cell adhesion due the weaker mechanical properties, which limits application considerably. In an effort overcome this disadvantage, we adopt unconventional dual network hydrogels consisting of polyethylene glycol diacrylate (PEGDA) covalent network,...
Due to its high biosafety, gellan gum (GG) hydrogel, a naturally occurring polysaccharide released by microorganisms, is frequently utilized in food and pharmaceuticals. In recent years, like GG, natural polysaccharide-based hydrogels have become increasingly popular 3D-printed biomedical engineering because of their simplicity processing, considerable shear thinning characteristic, minimal pH dependence. To mitigate the negative effects GG's biological inertia, poor cell adhesion, single...
PANoptosis has become an important way to systematically analyses and address extensive crosstalk common regulatory targets between different programmed cells death pathways. Focusing on the of bone marrow mesenchymal stem (BMSCs) induced by implants would be encouraging improve survival regeneration. In this study, we designed a liquid crystal hydrogel cement GelHap/TCLC, through phase state bionic mimic dynamic viscoelastic microenvironment bone, downregulate PANoptosis, wherein mouse...
Liquid crystals (LCs) are appealing biomaterials for applications in bone regenerative medicine due to their tunable physical properties and anisotropic viscoelastic behavior. This study reports a novel composite poly (L-lactide) (PLLA) scaffold that is manufactured by simple electrospinning biomineralization technique precisely controls the fibrous structure liquid LC phase. The enriched-LC composites have superior mineralization ability than neat PLLA; furthermore BMSC cells were...
Tumor necrosis factor-α is a common cytokine that increases in inflammatory processes, slows the differentiation of bone formation, and induces osteodystrophy long-term microenvironment. Our previous study confirmed Elongation protein 2 (ELP2) plays significant role osteogenesis osteogenic differentiation, which considered drug discovery target diseases related to formation differentiation. In this study, we applied an silico virtual screening method select molecules bind ELP2 from chemical...
Precise detection of Fe3+ ions in vitro is important for diagnosis disease and bone health. Covalent organic polymers (COPs) are chosen as the precision probes, due to their light-weight, stable-bonds, fast-response. In this work, a new fluorescent COP, pyrene-2,7-diboronic-COP(PD-COP), was designed its feasibility iron concentration cells tested. PD-COP showed good performance selective Fe3+, among other metal ions. Its high anti-interference property recyclability provide theoretical basis...
Objective To apply iTRAQ technology to observe changes in protein expression group the process of inducing C2C12 cells differentiation towards osteoblast by BMP-2. Methods The myoblast were seeded BMP-2 induced system for induction. In 7th day, was extracted and labeled with reagent. Then, mass spectrometric detection, data analysis differentially expressed proteins, biological information carried out. Results 23 significantly spots screened BMP-2-induced differentiated cell...
Objective To investigate the short-term clinical effect of double channel decompression and bone grafting through greater trochanter combined with allograft fibula propping in treatment osteonecrosis femoral head (ONFH). Methods Twenty two patients (23 hips) were included from November 2017 to February 2019. According Association Research Cirulation Osseous(ARCO) staging, there 13 hips at stageⅡgroup, aged 20 48 years old an average of(32.5±8.5)years old;10 stageⅢgroup, 18 45 of(32.7±8.6)...