- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sleep and Wakefulness Research
- Sleep and related disorders
- Tracheal and airway disorders
- Drug-Induced Hepatotoxicity and Protection
- Gout, Hyperuricemia, Uric Acid
- Non-Invasive Vital Sign Monitoring
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Hemodynamic Monitoring and Therapy
- Drug-Induced Adverse Reactions
- Pneumonia and Respiratory Infections
- Sleep and Work-Related Fatigue
- Medical Research and Treatments
- Respiratory viral infections research
- Cardiac Arrest and Resuscitation
- Cardiovascular and Diving-Related Complications
- Cystic Fibrosis Research Advances
- Case Reports on Hematomas
- Child Nutrition and Feeding Issues
- Inhalation and Respiratory Drug Delivery
Liverpool Hospital
2017-2025
Ingham Institute
2017-2025
South Western Sydney Local Health District
2017-2025
UNSW Sydney
2008-2025
Concord Repatriation General Hospital
2015
International Medical University
2009
St Vincent's Hospital
2008
St Vincent's Hospital Sydney
2008
Abstract The Epworth Sleepiness Scale is used frequently to measure excessive daytime sleepiness in research and clinical settings, although there limited evidence on test–retest reliability, particularly among sleep clinic populations. objective of this study was evaluate the reliability instrument adult patients recruited from a public hospital Sydney, Australia. English‐speaking participants self‐completed two occasions, at specialist visit night diagnostic polysomnography. Of 108...
Abstract Purpose Polysomnography (PSG) may be completed in the home environment (unattended), and when self-applied, allow collection of data with minimal healthcare worker intervention. Self-applied, unattended PSG using Somte V2 (Somte) has not been validated pregnant women early to mid-gestation. We undertook a study evaluate accuracy compared attended PSG. The agreement between apnoea hypopnea index (AHI) respiratory disturbance (RDI) scores mid-gestation were assessed. Methods Pregnant...
Background Obstructive sleep apnea (OSA) is a common disorder, and in pregnancy, it associated with an increased risk of complications, including gestational diabetes mellitus preeclampsia. Supine may worsen OSA, stillbirth due to effects on fetomaternal blood flow. Continuous positive airway pressure (CPAP) therapy considered the gold-standard treatment for moderate severe although compliance frequently poor; positional (PT) generally less effective than CPAP nonpregnant patients but be...
Abstract Background and Objective Hypercapnic respiratory failure (HRF) can occur due to severe disease but also because of multiple coexistent causes. There are few data on the prevalence antecedent causes for HRF effect these prognosis, especially where study inclusion has not been biased with respect primary diagnosis, interventions received or clinical outcome. We sought determine pre‐specified conditions among patients in‐hospital mortality. Methods Cross‐sectional from 2013 2017....
Objective We sought to describe the long-term prognosis for a population-based cohort of people with hypercapnic respiratory failure (HRF) and associations between underlying diagnoses risks death rehospitalisation. Methods performed historical study all persons HRF in Liverpool local government area New South Wales, Australia, 3-year period from 2013 2015. Cohort members were identified using arterial blood gas results Hospital demonstrating pH ≤7.45 PaCO 2 >45 mm Hg within 24 hours...
Abstract Background: International data suggest that suboptimal use of allopurinol is common. Allopurinol dose should be lower in renal impairment, but higher when gout not controlled. The aim the study was to examine trends usage Australian community. Methods: Community dispensing on urate‐lowering drugs and probenecid were obtained from databases kept by Medicare Australia Drug Utilization Sub‐Committee, for January 1992 December 2005. Results: comprised 98.4% all prescriptions dispensed...
Abstract Purpose There is a paucity of data on preferences for obstructive sleep apnoea (OSA) diagnostic tests during pregnancy. Simple test completion rates fail to capture patient preference or experience completing tests. We assessed preference, ease use, convenience, and the repeatability level I, II III tests, using questionnaires, in pregnant women early mid-gestation. Methods Pregnant with signs symptoms OSA, at high risk cardiometabolic disorders pregnancy completed studies by 24...
Abstract Background Evidence‐based screening tools are required for detection of daytime hypercapnia in high‐risk patient populations. Aims To determine the validity supine awake oximetry as a test and severe sleep disordered breathing ( SDB ) super‐obese patients. Methods This was cross‐sectional diagnostic evaluation adults (body mass index >50 kg/m 2 presenting to Liverpool Hospital, Australia, between 2009 2015 polysomnography PSG arterial blood gas measurement. Supine oxygen...
Abstract Objective There are no population-based data on the relative importance of specific causes hypercapnic respiratory failure (HRF). We sought to quantify associations between hospitalisation with HRF and potential antecedent including chronic obstructive pulmonary disease (COPD), sleep apnea, congestive cardiac failure. used prevalence these conditions estimate population attributable fraction for each cause. Methods A case–control study was conducted among residents aged ≥ 40 years...
Abstract General practitioner training on obstructive sleep apnoea and long-term care: a pilot study Introduction Obstructive (OSA) can be treated using continuous positive airway pressure (CPAP) therapy; however, many patients experience difficulties acclimatising persisting with this treatment. In view of the increasing prevalence OSA, evidence-based models care not limited to physicians are urgently required. A was conducted feasibility implementing an education session for general...
Transcutaneous carbon dioxide (Ptcco2) measurement is a non-invasive surrogate marker for arterial (Paco2), which requires invasive blood sampling. Use of Ptcco2 has been examined in different clinical settings, however, most existing evidence the adult emergency department (ED) setting shows insufficient agreement between measurements. This study assessed level and Paco2 undifferentiated ED patients across multiple timepoints.This prospective observational (study period 2020-2021) paired...
Abstract Introduction The detection of obstructive sleep apnoea (OSA) in pregnant women early gestation using polysomnography (PSG) was logistically difficult during covid-19 lockdowns. Reliable alternates to PSG haven’t been well validated pregnancy. We compared the agreement between self-applied, unattended Somte and attended PSG, by 24 weeks gestation. Methods Women were recruited undergo Grael Tests scored a single experienced scorer (blinded result). An apnoea-hypopnea index (AHI) 5 or...
Abstract Introduction A range of test options are available to diagnose OSA. Test acceptability is measured via successful completion, though this fails capture the patient preference. There a paucity data on particularly in pregnancy. We thus developed questionnaires assess preference and Apnealink-Air, Somte Grael tests, pregnancy till 24 weeks gestation. Methods Eighty-four pregnant women by gestation were invited complete home unattended-self-applied-Somte-PSG attended-Grael-PSG....
<sec> <title>BACKGROUND</title> Obstructive sleep apnea (OSA) is a common disorder, and in pregnancy, it associated with an increased risk of complications, including gestational diabetes mellitus preeclampsia. Supine may worsen OSA, stillbirth due to effects on fetomaternal blood flow. Continuous positive airway pressure (CPAP) therapy considered the gold-standard treatment for moderate severe although compliance frequently poor; positional (PT) generally less effective than CPAP...