A5049938387- DNA Repair Mechanisms
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Nerve injury and regeneration
- Immune cells in cancer
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Mitochondrial Function and Pathology
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- Nuclear Receptors and Signaling
- interferon and immune responses
- DNA and Nucleic Acid Chemistry
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
Gansu Provincial Hospital
2025
Sun Yat-sen University
2025
Gansu Provincial Cancer Hospital Gansu Provincial Academic Instiute for Medical Research
2015-2024
Lanzhou University
2015-2016
We aim to construct a RiskScore model aid in the early prognosis of breast cancer (BC). BC mRNA expression profiles were obtained from TCGA and GEO databases. Differential gene analysis identifies PDP1-ferroptosis-related genes. LASSO Cox regression was utilized screen genes build model, survival performed investigate reliability prognosis. Immune cell infiltration proportions calculated using CIBERSORT xCell algorithms. Single-cell data processing conducted "Seurat", "monocle", "iTALK"...
The evident side effects and decreased drug sensitivity significantly restrict the use of chemotherapy. However, nanoparticles based on biomaterials are anticipated to address this challenge. Through bioinformatics analysis colon cancer samples, we initially investigated expression level RNF8 in cancer. Next, constructed nanocarrier for delivering siRNF8 DNA tetrahedron (si-Tet), Doxorubicin (DOX) was further intercalated into structure (si-DOX-Tet) combination therapy. Further, mechanism...
// Mei-Jun Zhao 1,* , Yan-Feng Song Hai-Tao Niu 3,* Ying-Xia Tian 1,2,* Xu-Guang Yang 1 Kun Xie Yu-Hong Jing and De-Gui Wang Department of Anatomy Histology, School Basic Medical Sciences, Lanzhou University, Lanzhou, China 2 Internal Medicine, Gansu Provincial Academic Institute for Research, 3 Urology, Affiliated Hospital Qingdao Qingdao, * These authors have contributed equally to this work Correspondence to: Wang, email: Keywords : bladder cancer, adenovirus, RNF8, radiotherapy, gene...
RAD6 participates in DNA double-strand breaks (DSBs) repair by ubiquitinating histone H2B mitotic cells. In terminally differentiated cells, however, the mechanisms of damage are less well known. this study, we investigate whether RAD6B is involved DSBs neurons and effects deficiency on neuronal survival. We compared RAD6B-deficient mice with those littermate wild type (WT) induced X-ray irradiation. provide evidence that essential for neural DDR results increased genomic instability...
SRY‑related high‑mobility group box 9 (SOX9) is an important transcriptional factor that regulates diverse genes involved in development and stemness. Dysregulation of SOX9 encourages carcinogenesis various types cancer, including breast cancer. The present study aimed to explore the role triple‑negative cancer (TNBC). expression was significantly upregulated TNBC MDA‑MB‑231, MDA‑MB‑436 MDA‑MB‑468 cell lines compared with BT‑549 cells. Based on a lentivirus assay, inhibition MDA‑MB‑231 cells...
Adenovirus-mediated gene therapy is a promising strategy for bladder cancer treatment. However, the loss of coxsackie and adenovirus receptor (CAR) in cells decreases infection efficiency therapeutic adenovirus. In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries suicide called HSV-TK driven by human UPII promoter. Then, tested specificity promotor expression protein. Additionally, observed potent cytotoxic effects RGDAd-UPII-TK ganciclovir...