A5042791534- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Immune Response and Inflammation
- interferon and immune responses
- Microbial infections and disease research
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Plant Virus Research Studies
- Vibrio bacteria research studies
- Peptidase Inhibition and Analysis
- CRISPR and Genetic Engineering
- Wikis in Education and Collaboration
Université Paris Cité
2023-2024
Institut Pasteur
2023-2024
Inserm
2023-2024
Zhejiang University
2023
In recent years, a vast number of novel antiphage defense mechanisms were uncovered. To facilitate the exploration mechanistic, ecological, and evolutionary aspects related to systems, we released DefenseFinder in 2021 (Tesson et al., 2022). is bioinformatic program designed for systematic identification known mechanisms. The initial release v1.0.0 included 60 systems. Over past three systems incorporated into has grown 152. increasing makes it challenge enter field interpretation detections...
Abstract Predicting how phages can selectively infect specific bacterial strains holds promise for developing novel approaches to combat infections and better understanding microbial ecology. Experimental studies on phage-bacteria interactions have been mostly focusing a few model organisms understand the molecular mechanisms which makes particular strain susceptible given phage. However, both bacteria are extremely diverse in natural contexts. How well concepts learned from well-established...
Abstract Bacteria synthesize natural products to adapt their environment, where phage-bacteria interactions play a crucial role in bacterial ecology. Although few have been shown protect bacteria from phage infection, the prevalence and diversity of chemical anti-phage defense remain largely unexplored. Here, we uncover novel family over 2000 lanthipeptide biosynthetic gene clusters Actinobacteria that participate defense, which named lanthiphages. Lanthiphages colocalize with other systems...
Phages are ubiquitous in nature, and bacteria with very different genomics, metabolisms, lifestyles subjected to their predation. Yet, the defence systems that allow resist phages have rarely been explored experimentally outside a limited number of model organisms. Actinobacteria (Actinomycetota) phylum GC-rich Gram-positive bacteria, which often produce an important diversity secondary metabolites. Despite being wide range environments, from soil fresh sea water but also gut microbiome,...
Abstract Evolutionary arms races between cells and viruses drive the rapid diversification of antiviral genes in diverse life forms. Recent discoveries have revealed existence shared immune prokaryotes eukaryotes, showing molecular mechanistic similarities their response to viruses. However, underlying evolutionary dynamics that explain conservation adaptation these remain mostly unexplored. Here, we show viperins constitute a highly conserved family across uncover mechanisms by which they...
Abstract Phages are ubiquitous in nature, and bacteria with very different genomics, metabolisms, lifestyles subjected to their predation. Yet, the defense systems that allow resist phages have rarely been explored experimentally outside a limited number of model organisms. Actinobacteria phylum GC-rich gram-positive bacteria, which often produce an important diversity secondary metabolites. Despite being wide range environments, from soil fresh sea water but also gut microbiome, relatively...