A5064646361- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Dietary Effects on Health
- Spine and Intervertebral Disc Pathology
- Neurobiology and Insect Physiology Research
- Antioxidants, Aging, Portulaca oleracea
- High Altitude and Hypoxia
- Genomics, phytochemicals, and oxidative stress
- Genetics, Aging, and Longevity in Model Organisms
- Air Quality and Health Impacts
- Pregnancy-related medical research
- Advanced Chemical Sensor Technologies
- Adipose Tissue and Metabolism
- Infrared Thermography in Medicine
Manchester Academic Health Science Centre
2021-2024
University of Manchester
2014-2024
Wellcome Centre for Cell-Matrix Research
2020-2024
The disruption of the NRF2 (nuclear factor erythroid-derived 2-like 2)/glutathione-mediated antioxidant defense pathway is a critical step in pathogenesis several chronic pulmonary diseases and cancer. While mechanism activation upon oxidative stress has been widely investigated, little known about endogenous signals that regulate lung physiology pathology. Here we show an E-box-mediated circadian rhythm protein essential regulating rhythmic expression genes involved glutathione redox...
The circadian clock in mammals temporally coordinates physiological and behavioural processes to anticipate daily rhythmic changes their environment. Chronic disruption rhythms (e.g., through ageing or shift work) is thought contribute a multitude of diseases, including degeneration the musculoskeletal system. intervertebral disc (IVD) spine contains clocks which control ∼6% transcriptome manner, key genes involved extracellular matrix (ECM) homeostasis. However, it remains largely unknown...
Daily rhythms in mammalian behaviour and physiology are generated by a multi-oscillator circadian system entrained through environmental cues (e.g. light feeding). The presence of tissue niche-dependent physiological time has been proposed, allowing tissues the ability phase adjustment based on local signals. However, to date, such stimuli have remained elusive. Here we show that daily patterns mechanical loading associated osmotic challenge within ranges reset clock amplitude cartilage...
Evolutionarily conserved circadian clocks generate 24-hour rhythms in physiology and behaviour that adapt organisms to their daily seasonal environments. In mammals, the suprachiasmatic nucleus (SCN) of hypothalamus is principal co-ordinator cell-autonomous distributed across all major tissues. The importance robust highlighted by experimental epidemiological associations between disruption human diseases. BMAL1 (a bHLH-PAS domain-containing transcription factor) master positive regulator...
ObjectiveCartilage in joints such as the hip and knee experiences repeated phases of heavy loading low load recovery during 24-h day/night cycle. Our previous work has shown 24 h rhythmic changes gene expression at transcript level between night day wild type mouse cartilage which is lost a circadian clock knock-out model. However, it remains unknown to what extent rhythms also regulate protein this matrix rich tissue.MethodsWe investigated daily abundance femoral head articular by...
Abstract The circadian clock in mammals temporally coordinates physiological and behavioural processes to anticipate daily rhythmic changes their environment. Chronic disruption rhythms (e.g., through ageing or shift work) is thought contribute a multitude of diseases, including degeneration the musculoskeletal system. intervertebral disc (IVD) spine contains clocks which control ∼6% transcriptome manner, key genes involved extracellular matrix (ECM) homeostasis. However, it remains largely...
The circadian clock in murine articular cartilage is a critical temporal regulatory mechanism for tissue homeostasis and osteoarthritis. However, translation of these findings into humans has been hampered by the difficulty obtaining time series human tissues. As such, suitable model needed to understand initiation regulation rhythms cartilage.
Kidney physiology shows diurnal variation, and a disrupted circadian rhythm is associated with kidney disease. However, it remains largely unknown whether glomeruli, the filtering units in kidney, are under control. Here, we investigated core clock components together their rhythmic targets modes of regulation. With gene reporter mice, cell-autonomous glomerular clocks which likely govern fluctuations were identified. Using time-series transcriptomic profiling, first transcriptome 375...
Objective: Prior studies have shown that disruption of the circadian clock leads to cartilage degeneration in mice while shift work is associated with higher risk osteoarthritis (OA) humans. In this study we investigated potential heat pulses restore dampened rhythms articular cartilage. Methods: Femoral head explants and primary chondrocytes were isolated from PER2::LUC mice. Human femoral condyle was obtained osteoarthritic patients undergoing total knee replacement. Tissues cells exposed...
Abstract Daily rhythms in mammalian behaviour and physiology are generated by a multi-oscillator circadian system entrained through environmental cues (e.g. light). Presence of niche-dependent physiological time has been proposed, allowing local tissues flexibility phase adjustment. However, to date, such stimuli have remained elusive. Here we show that cycles mechanical loading osmotic within range drive rhythmic expression clock genes reset amplitude cartilage intervertebral disc tissues....