A5006859067- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Mental Health Research Topics
- Mitochondrial Function and Pathology
- Radiology practices and education
- Photoreceptor and optogenetics research
- Cancer and Skin Lesions
- Memory and Neural Mechanisms
- Bioinformatics and Genomic Networks
- Radiation Dose and Imaging
- Health, Environment, Cognitive Aging
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Healthcare professionals’ stress and burnout
- Breast Lesions and Carcinomas
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
University of Alabama at Birmingham
2020-2025
University of Alabama
2024
St. Vincent's Birmingham
2023
Brain connectivity arises from interactions across biophysical scales, ranging molecular to cellular anatomical network level. To date, there has been little progress toward integrated analysis these scales. bridge this gap, a unique cohort of 98 individuals, we collected antemortem neuroimaging and genetic data, as well postmortem dendritic spine morphometric, proteomic gene expression data the superior frontal inferior temporal gyri. Through integration morphology identified hundreds...
Episodic memory in older adults is varied and perceived to rely on numbers of synapses or dendritic spines. We analyzed 2157 neurons among 128 individuals from the Religious Orders Study Rush Memory Aging Project. Analysis 55,521 individual spines by least absolute shrinkage selection operator regression nested model cross-validation revealed that spine head diameter temporal cortex, but not premotor improved prediction episodic performance models containing β amyloid plaque scores,...
Dendritic spines are small protrusions on dendrites that serve as the postsynaptic site of majority excitatory synapses. These structures important for normal synaptic transmission, and alterations in their density morphology have been documented various disease states. Over 130 years ago, Ramón y Cajal used Golgi-stained tissue sections to study dendritic morphology. Despite array technological advances, including iontophoretic microinjection Lucifer yellow (LY) fluorescent dye, Golgi...
Cylindroma is a benign adnexal tumor histologically characterized by clusters of small basaloid cells arranged in pattern resembling jigsaw puzzle. Breast cylindromas are extremely rare with approximately 20 reported cases throughout literature. We present case 71-year-old female slow growing cystic breast mass, originally identified 8 years prior to biopsy. Mammography and ultrasound demonstrated features simple cyst circumscribed margins anechoic internal echogenicity, respectively. Biopsy...
Neuroimaging is commonly used to infer human brain connectivity, but those measurements are far-removed from the molecular underpinnings at synapses. To uncover basis of we analyzed a unique cohort 98 individuals who provided neuroimaging and genetic data contemporaneous with dendritic spine morphometric, proteomic, gene expression superior frontal inferior temporal gyri. Through cellular contextualization morphology, identified hundreds proteins related synapses, energy metabolism, RNA...