A5010122056- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Silymarin and Mushroom Poisoning
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Molecular Research
- Signaling Pathways in Disease
- Genomics and Chromatin Dynamics
- Curcumin's Biomedical Applications
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Peptidase Inhibition and Analysis
- Helicobacter pylori-related gastroenterology studies
- Systemic Lupus Erythematosus Research
- Clostridium difficile and Clostridium perfringens research
- Tissue Engineering and Regenerative Medicine
- Macrophage Migration Inhibitory Factor
- Genetics and Neurodevelopmental Disorders
- Galectins and Cancer Biology
- Histone Deacetylase Inhibitors Research
Max Delbrück Center
2017-2023
Chosun University
2014-2020
Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases (CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link caspase-8-dependent HCC development via proliferation- replication-associated DNA damage. Proliferation-associated replication stress, damage, genetic instability are detectable in CLDs before any neoplastic changes occur. Accumulated levels determine predict subsequent hepatocarcinogenesis. damage sensed by complex...
RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair double-strand breaks (DSBs), functions 53BP1-Shieldin pathway inhibits resection ends to modulate cellular decision on which engage. Under conditions replication stress, protects nascent at stalled forks from degradation by DNA2 nuclease. How these activities are regulated post-translational level has not yet been elucidated. Here, we identified cluster conserved ATM/ATR consensus SQ...
Class switch recombination (CSR) is a DNA reaction that diversifies the effector functions of antibodies. CSR occurs via formation and non-homologous end joining (NHEJ) repair programmed double-strand breaks (DSBs) at immunoglobulin heavy chain locus. The factors 53BP1 Rif1 promote NHEJ by protecting DSBs against resection. However, to what extent repression resection contributes unknown. Here, we show B lymphocytes devoid 53BP1-Rif1-dependent DSB protection activity undergo robust CSR....
We show that silymarin, a polyphenolic fl avonoid isolated from milk thistle (Silybum marianum), inhibits cytokine mixture (CM: TNF-α, IFN-γ, and IL-1β)-induced production of nitric oxide (NO) in the pancreatic beta cell line MIN6N8a.Immunostaining Western blot analysis showed silymarin iNOS gene expression.RT-PCR expression dose-dependent manner.We also extracellular signal-regulated protein kinase-1 2 (ERK1/2) phosphorylation.A MEK1 inhibitor abrogated CM-induced nitrite production,...
// Devakumar Sundaravinayagam 1, 2, * , Hye Rim Kim 3, TingTing Wu Hyun Hee 3 Hyun-Seo Lee 2 Semo Jun Jeong-Heon Cha 4 Younghoon Kee 5 Ho Jin You Jung-Hee 1 Laboratory of Genomic Instability and Cancer Therapeutics, Mutation Research Center, Chosun University School Medicine, Gwangju, Republic Korea Department Pharmacology, Cellular Molecular Oral Biology, Applied Life Science, The Graduate School, Yonsei College Dentistry, Seoul, Cell Microbiology, Arts Sciences, South Florida, Tampa,...
The establishment of protective humoral immunity is dependent on the ability mature B cells to undergo antibody gene diversification while adjusting physiological stressors induced by activation with antigen. Mature diversify their genes class switch recombination (CSR) and somatic hypermutation (SHM), which are both efficient induction activation-induced cytidine deaminase (AID). Here, we identified PDGFA-associated protein 1 (Pdap1) as an essential regulator cellular homeostasis in cells....
Critical illness myopathy (CIM) is an acquired, devastating, multifactorial muscle-wasting disease with incomplete recovery. The impact on hospital costs and permanent loss of quality life enormous. Incomplete recovery might imply that the function muscle stem cells (MuSC) impaired. We tested whether epigenetic alterations could be in part responsible. characterized human isolated from early CIM analyzed (CIM n = 15, controls 21) by RNA-Seq, immunofluorescence, analysis DNA repair, ATAC-Seq....
Abstract The establishment of protective humoral immunity is dependent on the ability mature B cells to undergo antibody gene diversification while adjusting physiological stressors induced by activation with antigen. Mature diversify their genes class switch recombination (CSR) and somatic hypermutation (SHM), which are both efficient induction activation-induced cytidine deaminase (AID). Here, we identified PDGFA-associated protein 1 (Pdap1) as an essential regulator cellular homeostasis...